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Identification
HMDB Protein ID HMDBP01044
Secondary Accession Numbers
  • 6333
Name Peroxisomal 2,4-dienoyl-CoA reductase
Synonyms
  1. 2,4-dienoyl-CoA reductase 2
  2. pDCR
Gene Name DECR2
Protein Type Enzyme
Biological Properties
General Function Involved in oxidoreductase activity
Specific Function Auxiliary enzyme of beta-oxidation. Participates in the degradation of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions in peroxisome. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3-enoyl-CoA. Has activity towards short and medium chain 2,4-dienoyl-CoAs, but also towards 2,4,7,10,13,16,19-docosaheptaenoyl-CoA, suggesting that it does not constitute a rate limiting step in the peroxisomal degradation of docosahexaenoic acid.
Pathways
  • Peroxisome
Reactions
Trans-2,3-didehydroacyl-CoA + NADP → trans,trans-2,3,4,5-tetradehydroacyl-CoA + NADPH details
GO Classification
Biological Process
unsaturated fatty acid biosynthetic process
Cellular Component
peroxisome
Function
binding
catalytic activity
oxidoreductase activity
Molecular Function
2,4-dienoyl-CoA reductase (NADPH) activity
trans-2-enoyl-CoA reductase (NADPH) activity
nucleotide binding
Process
metabolic process
oxidation reduction
Cellular Location
  1. Peroxisome
Gene Properties
Chromosome Location 16
Locus 16p13.3
SNPs DECR2
Gene Sequence
>879 bp
ATGGCCCAGCCGCCGCCCGACGTGGAGGGGGACGACTGTCTCCCCGCGTACCGCCACCTC
TTCTGCCCGGACCTGCTGCGGGACAAAGTGGCCTTCATCACAGGAGGCGGCTCTGGGATT
GGGTTCCGGATTGCTGAGATTTTCATGCGGCACGGCTGCCATACGGTGATTGCCAGTAGG
AGCCTGCCGCGAGTGCTGACGGCCGCCAGGAAGCTGGCTGGGGCCACCGGCCGGCGCTGC
CTCCCTCTCTCTATGGACGTCCGAGCGCCCCCAGCTGTCATGGCCGCCGTGGACCAGGCT
CTGAAGGAGTTTGGCAGAATCGACATTCTCATTAACTGTGCGGCCGGGAACTTCCTGTGC
CCCGCTGGCGCCTTGTCCTTCAACGCCTTCAAGACCGTGATGGACATCGATACCAGCGGC
ACCTTCAATGTGTCTCGTGTGCTCTATGAGAAGTTCTTCCGGGACCACGGAGGGGTGATC
GTGAACATCACTGCCACCCTGGGGAACCGGGGGCAGGCGCTCCAGGTGCATGCAGGCTCC
GCCAAGGCCGCTGTGGACGCGATGACGCGGCACTTGGCTGTGGAGTGGGGTCCCCAAAAC
ATCCGCGTCAACAGCCTCGCCCCTGGCCCCATCAGTGGCACAGAGGGGCTCCGGCGACTG
GGTGGCCCTCAGGCCAGCCTGAGCACCAAGGTCACTGCCAGCCCGCTGCAGAGGCTGGGG
AACAAGACCGAGATCGCCCACAGCGTGCTCTACCTGGCCAGCCCTCTGGCTTCCTACGTG
ACGGGGGCCGTGCTGGTGGCCGATGGCGGGGCATGGTTGACGTTCCCAAACGGTGTCAAA
GGGCTGCCGGATTTCGCATCCTTCTCTGCTAAGCTCTAG
Protein Properties
Number of Residues 292
Molecular Weight 30777.235
Theoretical pI 9.221
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>Peroxisomal 2,4-dienoyl-CoA reductase
MAQPPPDVEGDDCLPAYRHLFCPDLLRDKVAFITGGGSGIGFRIAEIFMRHGCHTVIASR
SLPRVLTAARKLAGATGRRCLPLSMDVRAPPAVMAAVDQALKEFGRIDILINCAAGNFLC
PAGALSFNAFKTVMDIDTSGTFNVSRVLYEKFFRDHGGVIVNITATLGNRGQALQVHAGS
AKAAVDAMTRHLAVEWGPQNIRVNSLAPGPISGTEGLRRLGGPQASLSTKVTASPLQRLG
NKTEIAHSVLYLASPLASYVTGAVLVADGGAWLTFPNGVKGLPDFASFSAKL
GenBank ID Protein 14336698
UniProtKB/Swiss-Prot ID Q9NUI1
UniProtKB/Swiss-Prot Entry Name DECR2_HUMAN
PDB IDs
GenBank Gene ID AE006463
GeneCard ID DECR2
GenAtlas ID DECR2
HGNC ID HGNC:2754
References
General References
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