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Identification
HMDB Protein ID HMDBP01059
Secondary Accession Numbers
  • 6348
  • HMDBP03961
Name Riboflavin kinase
Synonyms
  1. ATP:riboflavin 5'-phosphotransferase
  2. Flavokinase
Gene Name RFK
Protein Type Unknown
Biological Properties
General Function Involved in riboflavin kinase activity
Specific Function Catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin-mononucleotide (FMN).
Pathways
  • FMN biosynthesis
  • Riboflavin metabolism
  • Riboflavin Metabolism
Reactions
Adenosine triphosphate + Riboflavin → ADP + Flavin mononucleotide details
GO Classification
Biological Process
FMN biosynthetic process
riboflavin biosynthetic process
Cellular Component
cytosol
mitochondrion
Function
catalytic activity
transferase activity
transferase activity, transferring phosphorus-containing groups
kinase activity
riboflavin kinase activity
Molecular Function
metal ion binding
ATP binding
riboflavin kinase activity
Process
metabolic process
nitrogen compound metabolic process
riboflavin metabolic process
riboflavin biosynthetic process
Cellular Location
  1. Cytoplasm
Gene Properties
Chromosome Location 9
Locus 9q21.13
SNPs RFK
Gene Sequence
>468 bp
ATGAGGCACCTGCCTTACTTCTGCCGGGGTCAAGTGGTGCGGGGCTTCGGCCGCGGCTCC
AAGCAGCTGGGCATCCCCACAGCTAATTTTCCTGAGCAAGTGGTAGATAATCTTCCAGCT
GATATATCCACTGGTATTTACTATGGTTGGGCCAGTGTTGGAAGTGGAGATGTCCATAAG
ATGGTGGTGAGCATAGGATGGAACCCATATTACAAGAATACGAAGAAGTCTATGGAAACA
CATATCATGCATACCTTCAAAGAGGACTTCTATGGGGAAATCCTCAATGTGGCCATTGTT
GGCTACCTGAGACCAGAAAAGAACTTTGATTCTTTAGAGTCACTTATTTCAGCAATTCAA
GGTGATATTGAAGAAGCTAAGAAACGACTAGAGTTACCAGAACATTTGAAAATCAAAGAA
GACAATTTCTTCCAGGTTTCTAAAAGCAAAATAATGAATGGCCACTGA
Protein Properties
Number of Residues 155
Molecular Weight 17623.08
Theoretical pI 8.13
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>Riboflavin kinase
MRHLPYFCRGQVVRGFGRGSKQLGIPTANFPEQVVDNLPADISTGIYYGWASVGSGDVHK
MVVSIGWNPYYKNTKKSMETHIMHTFKEDFYGEILNVAIVGYLRPEKNFDSLESLISAIQ
GDIEEAKKRLELPEHLKIKEDNFFQVSKSKIMNGH
GenBank ID Protein 269973877
UniProtKB/Swiss-Prot ID Q969G6
UniProtKB/Swiss-Prot Entry Name RIFK_HUMAN
PDB IDs
GenBank Gene ID NM_018339.5
GeneCard ID RFK
GenAtlas ID RFK
HGNC ID HGNC:30324
References
General References
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  4. Karthikeyan S, Zhou Q, Mseeh F, Grishin NV, Osterman AL, Zhang H: Crystal structure of human riboflavin kinase reveals a beta barrel fold and a novel active site arch. Structure. 2003 Mar;11(3):265-73. [PubMed:12623014 ]