| Identification |
|---|
| HMDB Protein ID
| HMDBP01077 |
| Secondary Accession Numbers
| |
| Name
| Guanylate cyclase soluble subunit beta-2 |
| Synonyms
|
- GCS-beta-2
|
| Gene Name
| GUCY1B2 |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Involved in phosphorus-oxygen lyase activity |
| Specific Function
| Not Available |
| Pathways
|
Not Available
|
| Reactions
|
| Guanosine triphosphate → Cyclic GMP + Pyrophosphate |
details
|
|
| GO Classification
|
| Biological Process |
| blood coagulation |
| intracellular signal transduction |
| Cellular Component |
| cytoplasm |
| Function |
| ion binding |
| cation binding |
| metal ion binding |
| binding |
| catalytic activity |
| transition metal ion binding |
| lyase activity |
| iron ion binding |
| cyclase activity |
| heme binding |
| phosphorus-oxygen lyase activity |
| guanylate cyclase activity |
| Molecular Function |
| metal ion binding |
| heme binding |
| guanylate cyclase activity |
| GTP binding |
| Process |
| purine nucleotide metabolic process |
| purine nucleotide biosynthetic process |
| metabolic process |
| nitrogen compound metabolic process |
| cellular nitrogen compound metabolic process |
| nucleobase, nucleoside, nucleotide and nucleic acid metabolic process |
| nucleobase, nucleoside and nucleotide metabolic process |
| nucleoside phosphate metabolic process |
| nucleotide metabolic process |
| nucleoside monophosphate metabolic process |
| nucleoside monophosphate biosynthetic process |
| cyclic nucleotide biosynthetic process |
| cgmp biosynthetic process |
| intracellular signaling pathway |
| signaling |
| signaling pathway |
|
| Cellular Location
|
- Cytoplasm
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| GUCY1B2 |
| Gene Sequence
|
>1854 bp
ATGTCTGGCTATGACAGGATGCTACGGACACTGGGAGGAAATCTCATGGAGTTTATTGAA
AACCTGGATGCCCTCCACAGTTACCTGGCACTCTCTTATCAGGAGATGAATGCACCATCG
TTTCGTGTGGAGAGAGGAGCAGATGGGAAAATGTTTCTCCATTACTACTCGGATAGAAGT
GGTCTGTGCCACATTGTACCAGGTATCATTGAGGCTGTGGCCAAAGACTTCTTTGATATT
GATGTAATCATGGACATTCTTGACATGAATGAAGAAGTGGAGAGGACAGGGAAGAAGGAG
CATGTTGTGTTTCTGATTGTACAGAAGGCTCACAGGAAGATGAGAAAGACNAAGCCAAAA
AGGTTACAAGACAGTCAGGGCATGGAGAGAGACCAAGAGGCCCTCCAGGCAGCTTTCCTC
AAGATGAAGGAGAAATATTTGAATGTCTCTGCTTGTCCTGTGAAAAAATCCCACTGGGAT
GTTGTGAGAAGCATAGTCATGTTTGGAAAAGGGCATCTCATGAACACCTTTGAGCCAATT
TATCCTGAGAGACTCTGGATTGAAGAGAAGACATTCTGCAACGCTTTTCCTTTCCACATT
GTATTCGATGAATCACTACAGGTGAAGCAAGCCAGAGTGAACATTCAGAAGTACGTACCA
GGACTCCAAACCCAGAATATTCAACTGGATGAGTATTTCTCCATCATTCATCCTCAAGTT
ACCTTCAACATTTTCAGCATCCGCAGATTTATCAACAGTCAATTTGTCCTGAAGACACGA
AGAGAAATGATGCCTGTAGCATGGCAAAGTCGGACTACACTCAAACTTCAAGGCCAGATG
ATCTGGATGGAGTCCATGTGGTGCATGGTGTACCTGTGCTCTCCGAAGCTCCGCAGCCTG
CAAGAGCTGGAAGAACTCAATATGCATCTTTCTGACATCGCCCCCAACGACACCACCAGG
GATCTCATCCTCCTGAACCAGCAGCGGCTGGCTGAGATAGAGCTGTCCAACCAGCTGGAA
AGGAAGAAGGAGGAGCTACAGGTCCTCTCCAAGCACTTGGCCATTGAAAAGAAGAAAACA
GAGACCTTACTTTATGCCATGCTGCCCAAACACGTGGCCAACCAGCTGAGGGAGGGCAAA
AAGGTGGCTGCAGGAGAATTTAAAAGCTGCACGATTCTTTTCAGCGATGTAGTGACATTT
ACTAACATCTGTACTGCCTGTGAACCTATACAAATAGTGAACGTGCTGAATTCCATGTAC
TCCAAGTTTGACAGATTAACCAGTGTGCACGCAGTCTATAAAGTAGAAACAATAGGAGAT
GCTTATATGGTGGTAGGAGGTGTACCAGTGCCTATTGGAAACCATGCTCAAAGAGTGGCT
AATTTTGCCTTGGGGATGAGAATTTCTGCAAAGGAAGTGACGAATCCTGTTACTGGAGAA
CCCATCCAGCTCAGAGTGGGGATCCATACTGGACCAGTCTTAGCAGATGTTGTAGGAGAC
AAGATGCCACGGTACTGCTTGTTTGGTGACACTGTGAACACAGCTTCTAGGATGGAAAGT
CATGGGCTTCCCAACAAAGTGCACCTCAGTCCCACAGCCTACAGAGCCTTGAAAAATCAA
GGGTTTAAAATCATTGAGAGGGGTGAAATTGAAGTGAAAGGTAAAGGGAGAATGACCACA
TACTTTTTGATCCAGAACTTGAATGCCACAGAGGATGAGATCATGGGGAGATCTAAAACC
CCAGTTGATCACAAGGGGTCAACACAGAAAGCATCCTTGCCCACCACCAAGCTCCAGGGC
TCAGTTCAACCATCTTGCCCTGAACACTCTTCTCTTGCATCCTGGTTATTATGA
|
| Protein Properties |
|---|
| Number of Residues
| 617 |
| Molecular Weight
| Not Available |
| Theoretical pI
| Not Available |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Guanylate cyclase soluble subunit beta-2
MSGYDRMLRTLGGNLMEFIENLDALHSYLALSYQEMNAPSFRVERGADGKMFLHYYSDRS
GLCHIVPGIIEAVAKDFFDIDVIMDILDMNEEVERTGKKEHVVFLIVQKAHRKMRKTKPK
RLQDSQGMERDQEALQAAFLKMKEKYLNVSACPVKKSHWDVVRSIVMFGKGHLMNTFEPI
YPERLWIEEKTFCNAFPFHIVFDESLQVKQARVNIQKYVPGLQTQNIQLDEYFSIIHPQV
TFNIFSIRRFINSQFVLKTRREMMPVAWQSRTTLKLQGQMIWMESMWCMVYLCSPKLRSL
QELEELNMHLSDIAPNDTTRDLILLNQQRLAEIELSNQLERKKEELQVLSKHLAIEKKKT
ETLLYAMLPKHVANQLREGKKVAAGEFKSCTILFSDVVTFTNICTACEPIQIVNVLNSMY
SKFDRLTSVHAVYKVETIGDAYMVVGGVPVPIGNHAQRVANFALGMRISAKEVTNPVTGE
PIQLRVGIHTGPVLADVVGDKMPRYCLFGDTVNTASRMESHGLPNKVHLSPTAYRALKNQ
GFKIIERGEIEVKGKGRMTTYFLIQNLNATEDEIMGRSKTPVDHKGSTQKASLPTTKLQG
SVQPSCPEHSSLASWLL
|
| External Links |
|---|
| GenBank ID Protein
| 8081019 |
| UniProtKB/Swiss-Prot ID
| O75343 |
| UniProtKB/Swiss-Prot Entry Name
| GCYB2_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF038499 |
| GeneCard ID
| GUCY1B2 |
| GenAtlas ID
| GUCY1B2 |
| HGNC ID
| HGNC:4686 |
| References |
|---|
| General References
| - Behrends S, Vehse K: The beta(2) subunit of soluble guanylyl cyclase contains a human-specific frameshift and is expressed in gastric carcinoma. Biochem Biophys Res Commun. 2000 Apr 29;271(1):64-9. [PubMed:10777682 ]
- Behrends S, Kazmierczak B, Steenpa A, Knauf B, Bullerdiek J, Scholz H, Eiberg H: Assignment of GUCY1B2, the gene coding for the beta2 subunit of human guanylyl cyclase to chromosomal band 13q14.3 between markers D13S168 and D13S155. Genomics. 1999 Jan 1;55(1):126-7. [PubMed:9889008 ]
|
