| Identification |
|---|
| HMDB Protein ID
| HMDBP01108 |
| Secondary Accession Numbers
| |
| Name
| Monocarboxylate transporter 3 |
| Synonyms
|
- MCT 3
- Solute carrier family 16 member 8
|
| Gene Name
| SLC16A8 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in transmembrane transport |
| Specific Function
| Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
| Component |
| cell part |
| membrane part |
| intrinsic to membrane |
| integral to membrane |
| Function |
| transmembrane transporter activity |
| substrate-specific transmembrane transporter activity |
| transporter activity |
| organic acid transmembrane transporter activity |
| carboxylic acid transmembrane transporter activity |
| monocarboxylic acid transmembrane transporter activity |
| secondary active monocarboxylate transmembrane transporter activity |
| Process |
| establishment of localization |
| transport |
| organic anion transport |
| transmembrane transport |
| anion transport |
| ion transport |
|
| Cellular Location
|
- Cell membrane
- Multi-pass membrane protein
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:2 |
| Locus
| 22q12.3-q13.2 |
| SNPs
| SLC16A8 |
| Gene Sequence
|
>1515 bp
ATGGGCGCTGGCGGCCCCCGGCGGGGCGAGGGCCCCCCAGACGGCGGCTGGGGCTGGGTG
GTGCTGGGCGCCTGCTTTGTGGTCACCGGCTTCGCCTACGGCTTCCCCAAAGCCGTGAGC
GTCTTCTTCCGCGCGCTCATGCGCGACTTCGACGCCGGCTACAGCGACACGGCCTGGGTG
TCCTCCATCATGCTAGCCATGCTCTACGGCACGGGCCCCGTGTCCAGCATCCTCGTGACC
CGCTTTGGCTGTCGCCCGGTGATGCTGGCGGGTGGGCTGCTGGCTTCCGCGGGCATGATC
CTAGCTTCCTTTGCCACGCGCCTTCTGGAGCTCTACCTGACCGCTGGGGTGCTCACAGGC
CTGGGCCTGGCCCTCAACTTCCAGCCGTCGCTCATCATGCTGGGGCTGTACTTCGAGCGG
CGGCGGCCTCTGGCCAACGGGCTGGCGGCGGCGGGCAGCCCCGTGTTCCTGTCCGCGCTG
TCGCCGCTCGGCCAGCAGCTGCTGGAGCGCTTCGGCTGGCGCGGCGGCTTCCTGCTGCTC
GGCGGGCTCCTGCTGCACTGCTGCGCCTGCGGGGCTGTCATGAGGCCGCCGCCCGGGCCG
GGCCCGCGACCGCGCAGGGACAGCGCCGGCGACCGCGCCGGGGACGCTCCGGGCGAGGCG
GAGGCTGACGGTGCGGGGCTGCAGCTGCGCGAGGCATCCCCCTGGGTCCGGCCCCGCCGG
CGCCTGCTGGACTTGGCAGTGTGCACCGACCGCGCCTTCGCCGTGTACGCCGTCACCAAG
TTCCTGATGGCGCTCGGGCTCTTCGTCCCCGCCATCCTGCTGGTGAACTACGCCAAGGAC
GCGGGCGTGCCCGACACCGACGCCGCCTTCCTGCTGTCCATCGTGGGCTTCGTGGACATC
GTGGCGCGCCCGGCGTGCGGCGCCCTGGCGGGCCTGGCGCGTCTGCGGCCGCACGTCCCG
TATCTGTTCAGCCTGGCCCTGCTGGCCAATGGGCTCACAGACCTGAGCAGCGCACGCGCG
CGCTCCTACGGCGCCCTCGTCGCCTTCTGCGTCGCCTTCGGCCTCTCCTACGGCATGGTG
GGCGCGCTGCAGTTCGAGGTGCTCATGGCGGCTGTGGGCGCGCCCCGCTTCCCCAGTGCG
CTGGGCCTGGTGTTGCTCGTGGAGGCCGCGGCTGTGCTCATCGGACCGCCCTCTGCCGGC
CGCCTGGTGGATGCGTTGAAGAACTATGAGATCATCTTCTACCTGGCCGGCTCTGAGGTG
GCCCTGGCTGGGGTCTTCATGGCTGTCGCCACCAACTGCTGCCTGCGTTGTGCTAAAGCT
GCCCCGTCAGGCCCAGGCACTGAGGGCGGAGCCAGTGACACTGAGGACGCTGAGGCTGAA
GGGGACTCTGAGCCCCTGCCTGTTGTTGCAGAGGAACCCGGCAACCTGGAGGCCCTGGAG
GTGCTCAGCGCCCGGGGCGAGCCCACAGAACCAGAAATAGAGGCGAGGCCGAGGCTGGCT
GCCGAGTCTGTATAA
|
| Protein Properties |
|---|
| Number of Residues
| 504 |
| Molecular Weight
| 52318.2 |
| Theoretical pI
| 5.32 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
- 15-35
- 59-79
- 86-106
- 116-136
- 144-164
- 173-193
- 255-275
- 290-310
- 319-335
- 343-363
- 377-397
- 411-431
|
| Protein Sequence
|
>Monocarboxylate transporter 3
MGAGGPRRGEGPPDGGWGWVVLGACFVVTGFAYGFPKAVSVFFRALMRDFDAGYSDTAWV
SSIMLAMLYGTGPVSSILVTRFGCRPVMLAGGLLASAGMILASFATRLLELYLTAGVLTG
LGLALNFQPSLIMLGLYFERRRPLANGLAAAGSPVFLSALSPLGQQLLERFGWRGGFLLL
GGLLLHCCACGAVMRPPPGPGPRPRRDSAGDRAGDAPGEAEADGAGLQLREASPRVRPRR
RLLDLAVCTDRAFAVYAVTKFLMALGLFVPAILLVNYAKDAGVPDTDAAFLLSIVGFVDI
VARPACGALAGLARLRPHVPYLFSLALLANGLTDLSSARARSYGALVAFCVAFGLSYGMV
GALQFEVLMAAVGAPRFPSALGLVLLVEAAAVLIGPPSAGRLVDVLKNYEIIFYLAGSEV
ALAGVFMAVATNCCLRCAKAAPSGPGTEGGASDTEDAEAEGDSEPLPVVAEEPGNLEALE
VLSARGEPTEPEIEARPRLAAESV
|
| External Links |
|---|
| GenBank ID Protein
| 6103363 |
| UniProtKB/Swiss-Prot ID
| O95907 |
| UniProtKB/Swiss-Prot Entry Name
| MOT3_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF132610 |
| GeneCard ID
| SLC16A8 |
| GenAtlas ID
| SLC16A8 |
| HGNC ID
| HGNC:16270 |
| References |
|---|
| General References
| - Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP, et al.: The DNA sequence of human chromosome 22. Nature. 1999 Dec 2;402(6761):489-95. [PubMed:10591208 ]
- Yoon H, Donoso LA, Philp NJ: Cloning of the human monocarboxylate transporter MCT3 gene: localization to chromosome 22q12.3-q13.2. Genomics. 1999 Sep 15;60(3):366-70. [PubMed:10493836 ]
|
