Human Metabolome Database: Showing Protein Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit gamma (HMDBP01139)

Identification Biological properties Gene properties Protein properties External links References XML Show 2 metabolites

Identification

HMDB Protein ID

HMDBP01139

Secondary Accession Numbers

6435

Name

Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit gamma

Synonyms

PI3K-C2-gamma
Phosphoinositide 3-kinase-C2-gamma
PtdIns-3-kinase C2 subunit gamma

Gene Name

PIK3C2G

Protein Type

Enzyme

Biological Properties

General Function

Involved in binding

Specific Function

In vitro, phosphorylates PtdIns and PtdIns4P but not PtdIns(4,5)P2

Pathways

Not Available

Reactions

Not Available

GO Classification

Component
macromolecular complex
protein complex
phosphoinositide 3-kinase complex
Function
binding
catalytic activity
transferase activity
transferase activity, transferring phosphorus-containing groups
kinase activity
phosphotransferase activity, alcohol group as acceptor
protein binding
inositol or phosphatidylinositol kinase activity
lipid binding
phospholipid binding
phosphoinositide binding
lipid kinase activity
phosphoinositide 3-kinase activity
1-phosphatidylinositol-3-kinase activity
Process
metabolic process
cellular process
biological regulation
regulation of biological process
regulation of cellular process
signal transduction
intracellular signal transduction
organophosphate metabolic process
phospholipid metabolic process
cell communication
second-messenger-mediated signaling
phosphoinositide-mediated signaling
glycerophospholipid metabolic process
phosphoinositide metabolic process
phosphoinositide phosphorylation

Cellular Location

Peripheral membrane protein
Membrane

Gene Properties

Chromosome Location

Chromosome:1

Locus

12p12

SNPs

PIK3C2G

Gene Sequence

>4335 bp
ATGGCATATTCTTGGCAAACGGATCCAAATCCTAATGAATCACACGAAAAGCAGTATGAA
CACCAAGAATTTCTCTTTGTAAATCAACCCCATTCTTCTAGCCAAGTCAGTCTGGGTTTT
GATCAGATAGTAGATGAGATCAGTGGCAAAATTCCACACTACGAGAGTGAAATTGATGAA
AACACCTTTTTTGTGCCCACTGCACCAAAATGGGACTCAACAGGGCATTCATTAAATGAA
GCACACCAAATATCCTTGAATGAATTCACTTCTAAAAGCCGTGAACTCTCCTGGCATCAA
GTTAGCAAAGCACCAGCAATTGGTTTTAGTCCTTCTGTGTTACCAAAACCTCAAAATACG
AATAAAGAATGCTCCTGGGGAAGCATAGGAAAACATCATGGTGCTGATGATTCCAGATTC
AGTATTTTAGCTCTATCATTCACAAGTTTGGATAAAATTAATCTAGAGAAAGAATTAGAA
AATGAAAATCATAACTACCATATAGGATTTGAAAGTAGCATTCCTCCAACAAATTCATCC
TTCTCAAGTGACTTCATGCCGAAAGAAGAGAATAAAAGGAGTGGACATGTGAACATTGTG
GAACCATCTTTGATGCTTTTGAAAGGCTCTCTTCAACCCGGAATGTGGGAAAGTACATGG
CAGAAGAATATAGAGTCAATAGGTTGTTCCATTCAGCTAGTGGAAGTACCTCAAAGCAGC
AATACGAGTCTGGCCTCTTTTTGCAACAAAGTAAAAAAAATCAGAGAAAGATATCATGCA
GCTGATGTTAATTTCAATTCTGGGAAGATCTGGAGCACTACTACAGCATTTCCGTATCAG
CTCTTTTCTAAGACCAAGTTTAATATACATATTTTTATTGATAACTCAACACAACCTCTT
CATTTTATGCCATGTGCTAATTATCTTGTCAAAGATCTAATTGCAGAAATTCTGCATTTT
TGCACAAATGACCAGCTACTCCCCAAAGATCATATTCTAAGTGTATGTGGCTCTGAAGAA
TTTTTACAAAACGACCACTGTTTGGGGAGCCACAAAATGTTTCAAAAAGATAAATCTGTT
ATTCAGCTCCACCTGCAGAAAAGTAGGGAAGCTCCAGGAAAGCTATCTCGAAAGCATGAA
GAGGACCACAGTCAGTTTTATCTGAATCAACTTCTAGAATTTATGCATATTTGGAAAGTA
TCCAGACAATGTCTCTTAACACTCATCAGAAAATATGACTTCCACCTGAAATACCTATTG
AAAACCCAGGAAAACGTGTATAATATTATTGAAGAAGTTAAAAAAATATGCAGTGTTCTA
GGGTGTGTGGAAACCAAACAAATTACAGATGCAGTAAATGAACTAAGTCTAATTCTTCAG
AGAAAAGGAGAGAATTTTTATCAAAGTTCAGAGACTTCAGCAAAAGGCTTGATAGAGAAG
GTAACAACTGAACTATCCACATCCATCTACCAGCTAATCAATGTCTACTGTAACAGCTTT
TATGCAGATTTTCAGCCTGTAAATGTACCTAGATGCACTTCCTATCTAAATCCCGGGCTT
CCTTCCCACCTCAGCTTCACAGTGTATGCAGCACACAACATTCCAGAAACCTGGGTGCAC
AGGATCAATTTTCCCCTTGAAATAAAGTCACTTCCAAGGGAATCCATGCTCACTGTAAAA
CTGTTTGGGATTGCCTGTGCAACCAACAATGCAAATTTACTGGCGTGGACTTGTCTTCCA
CTGTTTCCAAAAGAAAAATCCATTCTCGGGTCTATGCTGTTCAGCATGACATTACAGAGT
GAGCCTCCCGTAGAAATGATAACTCCAGGAGTGTGGGATGTAAGTCAGCCATCCCCGGTG
ACCCTGCAGATTGATTTTCCAGCTACTGGGTGGGAGTATATGAAACCTGATTCTGAAGAG
AATAGAAGTAATCTTGAAGAGCCACTAAAGGAGTGTATAAAACATATTGCCAGACTTTCA
CAGAAACAGACTCCCCTACTACTCTCTGAAGAAAAGAAAAGATATTTATGGTTTTATCGC
TTCTACTGCAATAATGAAAACTGCTCCCTTCCTTTAGTCCTGGGTAGTGCCCCTGGATGG
GATGAAAGGACTGTTTCAGAAATGCATACCATTTTGAGAAGATGGACATTTTCTCAACCT
TTAGAGGCTCTTGGGCTTTTGACTTCCAGTTTTCCAGATCAAGAAATTCGTAAAGTGGCA
GTTCAACAATTAGACAACCTCTTGAATGATGAACTACTGGAATATCTCCCACAGCTAGTT
CAGGCTGTCAAGTTTGAATGGAACCTTGAGAGTCCTTTAGTGCAACTTCTACTCCACCGC
TCCTTGCAGAGCATCCAGGTTGCCCATCGTCTTTACTGGCTGCTAAAAAATGCAGAAAAT
GAAGCTTATTTTAAAAGCTGGTATCAGAAGCTACTAGCTGCTCTCCAATTCTGTGCAGGT
AAAGCCTTGAATGATGAGTTTTCCAAGGAGCAGAAACTTATCAAAATTCTGGGAGATATT
GGGGAAAGAGTCAAGTCTGCCAGTGACCATCAAAGACAGGAGGTACTGAAGAAAGAAATT
GGCAGACTAGAAGAGTTCTTTCAAGATGTAAATACTTGTCATCTTCCTCTGAACCCTGCC
CTATGTATAAAAGGGATTGATCACGATGCATGTTCATATTTTACATCTAATGCTTTGCCA
TTGAAGATTACTTTCATCAATGCTAATCTGATGGGCAAAAACATCAGCATTATTTTTAAG
GCTGGAGATGATCTTCGTCAGGATATGCTTGTTCTGCAGCTTATTCAAGTGATGGACAAT
ATTTGGCTGCAGGAAGGCTTGGATATGCAAATGATCATTTATAGATGTCTATCCACAGGA
AAAGACCAAGGATTGGTGCAGATGGTACCTGATGCTGTGACCCTAGCAAAGATTCATCGC
CATTCTGGACTGATAGGACCATTGAAAGAAAATACAATTAAAAAGTGGTTCAGTCAGCAC
AACCACTTAAAGGCAGATTATGAAAAGGCCTTGAGGAACTTTTTCTACTCCTGTGCTGGC
TGGTGTGTGGTAACATTCATCCTGGGAGTATGTGACCGTCACAATGATAATATCATGCTG
ACAAAGTCGGGCCACATGTTTCATATTGACTTTGGAAAATTCTTAGGTCATGCACAAACA
TTTGGAGGGATAAAAAGGGACCGAGCTCCTTTCATTTTTACTTCAGAGATGGAATACTTT
ATTACAGAGGGTGGGAAAAACCCACAGCATTTTCAAGATTTTGTGGAACTTTGCTGTCGT
GCTTATAATATTATCAGAAAGCACAGCCAACTGCTCTTGAACCTGCTGGAAATGATGCTG
TATGCAGGACTGCCTGAGCTAAGTGGAATTCAAGACCTGAAATATGTGTATAATAATCTT
CGTCCACAAGACACAGACCTGGAAGCAACAAGTCATTTTACCAAGAAAATAAAGGAAAGT
CTGGAGTGTTTCCCTGTTAAATTGAATAACTTGATCCACACACTTGCACAAATGTCAGCC
ATAAGCCCTGCCAAATCTACTTCACAGACTTTTCCTCAGGAATCCTGTTTGCTGAGTACA
ACTAGGTCGATTGAAAGAGCAACAATTTTAGGGTTCAGCAAGAAATCCAGTAATCTGTAT
CTGATCCAGGTGACACACAGCAACAACGAAACAAGCCTGACAGAAAAATCATTTGAGCAG
TTTTCAAAACTTCACAGCCAACTTCAGAAGCAGTTTGCATCACTGACTCTCCCAGAGTTT
CCTCATTGGTGGCACCTACCTTTTACAAATTCAGATCACAGAAGATTCAGAGATCTAAAT
CATTACATGGAACAGATATTAAATGTATCACATGAAGTTACAAACAGTGATTGTGTACTT
AGCTTTTTCCTCTCTGAGGCTGTGCAACAAACAGTTGAAGAATCATCACCTGTGTACCTA
GGTGAGAAGTTTCCAGACAAGAAGCCTAAGGTGCAGTTAGTCATATCCTACGAGGATGTG
AAGCTGACCATACTAGTGAAACACATGAAAAACATTCATCTCCCAGATGGCTCTGCGCCC
AGTGCACATGTTGAATTTTATCTTTTACCATATCCCAGTGAAGTTCGTAGGAGGAAAACA
AAATCTGTTCCAAAATGTACGGACCCAACTTACAATGAAATTGTAGTATATGATGAAGTC
ACAGAGCTCCAAGGACATGTCTTAATGCTTATTGTGAAGAGTAAAACTGTATTTGTGGGA
GCAATTAACATCCGACTCTGTAGTGTCCCACTCGATAAAGAAAAATGGTATCCATTAGGA
AACAGTATAATTTGA

Protein Properties

Number of Residues

1444

Molecular Weight

165648.3

Theoretical pI

6.92

Pfam Domain Function

PX (PF00787 )
PI3_PI4_kinase (PF00454 )
PI3K_C2 (PF00792 )
PI3K_rbd (PF00794 )
PI3Ka (PF00613 )

Signals

None

Transmembrane Regions

None

Protein Sequence

>Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit gamma
MAYSWQTDPNPNESHEKQYEHQEFLFVNQPHSSSQVSLGFDQIVDEISGKIPHYESEIDE
NTFFVPTAPKWDSTGHSLNEAHQISLNEFTSKSRELSWHQVSKAPAIGFSPSVLPKPQNT
NKECSWGSIGKHHGADDSRFSILALSFTSLDKINLEKELENENHNYHIGFESSIPPTNSS
FSSDFMPKEENKRSGHVNIVEPSLMLLKGSLQPGMWESTWQKNIESIGCSIQLVEVPQSS
NTSLASFCNKVKKIRERYHAADVNFNSGKIWSTTTAFPYQLFSKTKFNIHIFIDNSTQPL
HFMPCANYLVKDLIAEILHFCTNDQLLPKDHILSVCGSEEFLQNDHCLGSHKMFQKDKSV
IQLHLQKSREAPGKLSRKHEEDHSQFYLNQLLEFMHIWKVSRQCLLTLIRKYDFHLKYLL
KTQENVYNIIEEVKKICSVLGCVETKQITDAVNELSLILQRKGENFYQSSETSAKGLIEK
VTTELSTSIYQLINVYCNSFYADFQPVNVPRCTSYLNPGLPSHLSFTVYAAHNIPETWVH
RINFPLEIKSLPRESMLTVKLFGIACATNNANLLAWTCLPLFPKEKSILGSMLFSMTLQS
EPPVEMITPGVWDVSQPSPVTLQIDFPATGWEYMKPDSEENRSNLEEPLKECIKHIARLS
QKQTPLLLSEEKKRYLWFYRFYCNNENCSLPLVLGSAPGWDERTVSEMHTILRRWTFSQP
LEALGLLTSSFPDQEIRKVAVQQLDNLLNDELLEYLPQLVQAVKFEWNLESPLVQLLLHR
SLQSIQVAHRLYWLLKNAENEAYFKSWYQKLLAALQFCAGKALNDEFSKEQKLIKILGDI
GERVKSASDHQRQEVLKKEIGRLEEFFQDVNTCHLPLNPALCIKGIDHDACSYFTSNALP
LKITFINANLMGKNISIIFKAGDDLRQDMLVLQLIQVMDNIWLQEGLDMQMIIYRCLSTG
KDQGLVQMVPDAVTLAKIHRHSGLIGPLKENTIKKWFSQHNHLKADYEKALRNFFYSCAG
WCVVTFILGVCDRHNDNIMLTKSGHMFHIDFGKFLGHAQTFGGIKRDRAPFIFTSEMEYF
ITEGGKNPQHFQDFVELCCRAYNIIRKHSQLLLNLLEMMLYAGLPELSGIQDLKYVYNNL
RPQDTDLEATSHFTKKIKESLECFPVKLNNLIHTLAQMSAISPAKSTSQTFPQESCLLST
TRSIERATILGFSKKSSNLYLIQVTHSNNETSLTEKSFEQFSKLHSQLQKQFASLTLPEF
PHWWHLPFTNSDHRRFRDLNHYMEQILNVSHEVTNSDCVLSFFLSEAVQQTVEESSPVYL
GEKFPDKKPKVQLVISYEDVKLTILVKHMKNIHLPDGSAPSAHVEFYLLPYPSEVRRRKT
KSVPKCTDPTYNEIVVYDEVTELQGHVLMLIVKSKTVFVGAINIRLCSVPLDKEKWYPLG
NSII

External Links

GenBank ID Protein

120659792

UniProtKB/Swiss-Prot ID

O75747

UniProtKB/Swiss-Prot Entry Name

P3C2G_HUMAN

PDB IDs

Not Available

GenBank Gene ID

GeneCard ID

GenAtlas ID

HGNC ID

References

General References

Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
Yu LR, Zhu Z, Chan KC, Issaq HJ, Dimitrov DS, Veenstra TD: Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra. J Proteome Res. 2007 Nov;6(11):4150-62. Epub 2007 Oct 9. [PubMed:17924679 ]
Rozycka M, Lu YJ, Brown RA, Lau MR, Shipley JM, Fry MJ: cDNA cloning of a third human C2-domain-containing class II phosphoinositide 3-kinase, PI3K-C2gamma, and chromosomal assignment of this gene (PIK3C2G) to 12p12. Genomics. 1998 Dec 15;54(3):569-74. [PubMed:9878262 ]