You are using an unsupported browser. Please upgrade your browser to a newer version to get the best experience on Human Metabolome Database.
Identification
HMDB Protein ID HMDBP01140
Secondary Accession Numbers
  • 6436
  • HMDBP09361
Name N-acetylgalactosamine kinase
Synonyms
  1. GalNAc kinase
  2. Galactokinase 2
Gene Name GALK2
Protein Type Enzyme
Biological Properties
General Function Involved in galactokinase activity
Specific Function Acts on GalNAc. Also acts as a galactokinase when galactose is present at high concentrations. May be involved in a salvage pathway for the reutilization of free GalNAc derived from the degradation of complex carbohydrates.
Pathways
  • Amino sugar and nucleotide sugar metabolism
  • Galactose metabolism
Reactions
Adenosine triphosphate + N-Acetyl-b-D-galactosamine → ADP + N-acetyl-alpha-D-galactosamine 1-phosphate details
Adenosine triphosphate + Beta-D-Galactose → ADP + Galactose 1-phosphate details
GO Classification
Biological Process
galactose metabolic process
Cellular Component
cytoplasm
Component
cell part
intracellular part
cytoplasm
Function
binding
catalytic activity
transferase activity
transferase activity, transferring phosphorus-containing groups
kinase activity
nucleoside binding
purine nucleoside binding
adenyl nucleotide binding
adenyl ribonucleotide binding
atp binding
phosphotransferase activity, alcohol group as acceptor
galactokinase activity
Molecular Function
ATP binding
galactokinase activity
N-acetylgalactosamine kinase activity
Process
phosphorus metabolic process
phosphate metabolic process
metabolic process
galactose metabolic process
cellular metabolic process
small molecule metabolic process
alcohol metabolic process
monosaccharide metabolic process
hexose metabolic process
phosphorylation
carbohydrate phosphorylation
Cellular Location Not Available
Gene Properties
Chromosome Location 15
Locus 15q21.1-q21.2
SNPs GALK2
Gene Sequence
>1377 bp
ATGGCTACAGAGAGCCCTGCTACGCGTCGGGTCCAGGTGGCAGAACATCCTAGGTTACTG
AAGCTAAAGGAGATGTTTAACTCCAAGTTTGGATCTATTCCCAAGTTTTATGTTCGAGCA
CCAGGAAGAGTCAACATAATAGGAGAGCATATAGATTATTGTGGATATTCTGTTCTTCCT
ATGGCTGTAGAACAAGATGTGCTAATAGCTGTAGAACCTGTGAAAACGTACGCTCTCCAA
CTGGCCAATACAAATCCCTTGTATCCGGACTTCAGTACTAGTGCTAATAACATCCAGATT
GATAAAACCAAGCCTTTGTGGCACAACTATTTCTTATGTGGACTTAAAGGAATTCAGGAA
CACTTTGGTCTTAGTAACCTGACTGGAATGAACTGCCTGGTAGATGGAAATATCCCACCA
AGTTCTGGCCTCTCCAGCTCCAGTGCTTTGGTCTGTTGTGCTGGCTTGGTGACGCTCACA
GTGCTGGGAAGGAATCTATCCAAGGTGGAACTTGCAGAAATCTGTGCCAAGAGTGAGCGT
TACATTGGCACTGAAGGAGGAGGCATGGACCAGTCTATATCATTTCTTGCAGAAGAAGGA
ACTGCCAAGTTGATAGAATTTAGTCCTCTGAGGGCAACCGATGTAAAACTCCCAAGTGGA
GCAGTGTTTGTGATTGCCAACAGTTGTGTGGAGATGAATAAGGCAGCAACTTCCCATTTC
AATATCAGGGTGATGGAGTGTCGGCTGGCTGCGAAGCTCCTGGCTAAATACAAAAGCTTG
CAATGGGACAAAGTACTGAGGCTGGAGGAGGTGCAGGCTAAACTAGGGATTAGTCTAGAA
GAAATGCTGTTGGTCACAGAAGATGCCCTTCATCCTGAACCCTATAACCCTGAGGAGATC
TGCAGGTGTCTGGGAATTAGCCTGGAGGAACTCCGAACCCAAATCCTGAGTCCAAACACT
CAAGATGTGCTCATCTTCAAACTCTATCAGCGGGCAAAGCATGTGTACAGCGAGGCTGCG
CGAGTGCTCCAGTTTAAGAAGATATGTGAAGAAGCACCTGAAAACATGGTCCAGCTGCTG
GGAGAGTTGATGAACCAGAGCCACATGAGCTGCCGGGACATGTATGAGTGCAGCTGCCCC
GAGCTGGATCAGCTGGTGGACATCTGTCGGAAGTTTGGGGCTCAAGGGTCACGACTTACT
GGAGCAGGATGGGGAGGCTGTACAGTATCAATGGTACCTGCGGACAAGCTGCCCAGCTTT
CTAGCAAATGTGCACAAAGCTTATTACCAGAGGAGTGATGGAAGCTTAGCACCGGAGAAG
CAAAGTTTGTTTGCTACCAAACCTGGAGGTGGGGCTTTGGTTTTGCTTGAGGCCTGA
Protein Properties
Number of Residues 458
Molecular Weight 49234.57
Theoretical pI 6.364
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>N-acetylgalactosamine kinase
MATESPATRRVQVAEHPRLLKLKEMFNSKFGSIPKFYVRAPGRVNIIGEHIDYCGYSVLP
MAVEQDVLIAVEPVKTYALQLANTNPLYPDFSTSANNIQIDKTKPLWHNYFLCGLKGIQE
HFGLSNLTGMNCLVDGNIPPSSGLSSSSALVCCAGLVTLTVLGRNLSKVELAEICAKSER
YIGTEGGGMDQSISFLAEEGTAKLIEFSPLRATDVKLPSGAVFVIANSCVEMNKAATSHF
NIRVMECRLAAKLLAKYKSLQWDKVLRLEEVQAKLGISLEEMLLVTEDALHPEPYNPEEI
CRCLGISLEELRTQILSPNTQDVLIFKLYQRAKHVYSEAARVLQFKKICEEAPENMVQLL
GELMNQSHMSCRDMYECSCPELDQLVDICRKFGAQGSRLTGAGWGGCTVSMVPADKLPSF
LANVHKAYYQRSDGSLAPEKQSLFATKPGGGALVLLEA
GenBank ID Protein 13477333
UniProtKB/Swiss-Prot ID Q01415
UniProtKB/Swiss-Prot Entry Name GALK2_HUMAN
PDB IDs
GenBank Gene ID BC005141
GeneCard ID GALK2
GenAtlas ID GALK2
HGNC ID HGNC:4119
References
General References
  1. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  2. Lee RT, Peterson CL, Calman AF, Herskowitz I, O'Donnell JJ: Cloning of a human galactokinase gene (GK2) on chromosome 15 by complementation in yeast. Proc Natl Acad Sci U S A. 1992 Nov 15;89(22):10887-91. [PubMed:1438294 ]
  3. Ai Y, Basu M, Bergsma DJ, Stambolian D: Comparison of the enzymatic activities of human galactokinase GALK1 and a related human galactokinase protein GK2. Biochem Biophys Res Commun. 1995 Jul 17;212(2):687-91. [PubMed:7542884 ]
  4. Pastuszak I, O'Donnell J, Elbein AD: Identification of the GalNAc kinase amino acid sequence. J Biol Chem. 1996 Sep 27;271(39):23653-6. [PubMed:8798585 ]