Hmdb loader
Survey
Identification
HMDB Protein ID HMDBP01168
Secondary Accession Numbers
  • 6464
Name Ephrin type-A receptor 5
Synonyms
  1. EHK-1
  2. EK7
  3. EPH homology kinase 1
  4. EPH-like kinase 7
  5. hEK7
Gene Name EPHA5
Protein Type Enzyme
Biological Properties
General Function Involved in ephrin receptor activity
Specific Function Receptor for members of the ephrin-A family. Binds to ephrin-A1, -A2, -A3, -A4 and -A5
Pathways Not Available
Reactions Not Available
GO Classification
Component
integral to plasma membrane
membrane
cell part
membrane part
intrinsic to membrane
integral to membrane
Function
protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase activity
binding
catalytic activity
transferase activity
transferase activity, transferring phosphorus-containing groups
kinase activity
nucleoside binding
purine nucleoside binding
adenyl nucleotide binding
adenyl ribonucleotide binding
atp binding
ephrin receptor activity
protein binding
protein kinase activity
Process
phosphorus metabolic process
phosphate metabolic process
enzyme linked receptor protein signaling pathway
transmembrane receptor protein tyrosine kinase signaling pathway
metabolic process
cellular metabolic process
protein amino acid phosphorylation
signaling
signaling pathway
cell surface receptor linked signaling pathway
phosphorylation
Cellular Location
  1. Membrane
  2. Single-pass type I membrane protein
Gene Properties
Chromosome Location Chromosome:4
Locus 4q13.1
SNPs EPHA5
Gene Sequence
>3114 bp
ATGCGGGGCTCGGGGCCCCGGGGTGCGGGACGCCGGCGGCCCCCAAGCGGCGGCGGCGAC
ACCCCCATCACCCCAGCGTCCCTGGCCGGCTGCTACTCTGCACCTCGACGGGCTCCCCTC
TGGACGTGCCTTCTCCTGTGCGCCGCACTCCGGACCCTCCTGGCCAGCCCCAGCAACGAA
GTGAATTTATTGGATTCACGCACTGTCATGGGGGACCTGGGATGGATTGCTTTTCCAAAA
AATGGGTGGGAAGAGATTGGTGAAGTGGATGAAAATTATGCCCCTATCCACACATACCAA
GTATGCAAAGTGATGGAACAGAATCAGAATAACTGGCTTTTGACCAGTTGGATCTCCAAT
GAAGGTGCTTCCAGAATCTTCATAGAACTCAAATTTACCCTGCGGGACTGCAACAGCCTT
CCTGGAGGACTGGGGACCTGTAAGGAAACCTTTAATATGTATTACTTTGAGTCAGATGAT
CAGAATGGGAGAAACATCAAGGAAAACCAATACATCAAAATTGATACCATTGCTGCCGAT
GAAAGCTTTACAGAACTTGATCTTGGTGACCGTGTTATGAAACTGAATACAGAGGTCAGA
GATGTAGGACCTCTAAGCAAAAAGGGATTTTATCTTGCTTTTCAAGATGTTGGTGCTTGC
ATTGCTCTGGTTTCTGTGCGTGTATACTATAAAAAATGCCCTTCTGTGGTACGACACTTG
GCTGTCTTCCCTGACACCATCACTGGAGCTGATTCTTCCCAATTGCTCGAAGTGTCAGGC
TCCTGTGTCAACCATTCTGTGACCGATGAACCTCCCAAAATGCACTGCAGCGCCGAAGGG
GAGTGGCTGGTGCCCATCGGGAAATGCATGTGCAAGGCAGGATATGAAGAGAAAAATGGC
ACCTGTCAAGTGTGCAGACCTGGGTTCTTCAAAGCCTCACCTCACATCCAGAGCTGCGGC
AAATGTCCACCTCACAGTTATACCCATGAGGAAGCTTCAACCTCTTGTGTCTGTGAAAAG
GATTATTTCAGGAGAGAGTCTGATCCACCCACAATGGCATGCACAAGACCCCCCTCTGCT
CCTCGGAATGCCATCTCAAATGTTAATGAAACTAGTGTCTTTCTGGAATGGATTCCGCCT
GCTGACACTGGTGGAAGGAAAGACGTGTCATATTATATTGCATGCAAGAAGTGCAACTCC
CATGCAGGTGTGTGTGAGGAGTGTGGCGGTCATGTCAGGTACCTTCCCCGGCAAAGCGGC
CTGAAAAACACCTCTGTCATGATGGTGGATCTACTCGCTCACACAAACTATACCTTTGAG
ATTGAGGCAGTGAATGGAGTGTCCGACTTGAGCCCAGGAGCCCGGCAGTATGTGTCTGTA
AATGTAACCACAAATCAAGCAGCTCCATCTCCAGTCACCAATGTGAAAAAAGGGAAAATT
GCAAAAAACAGCATCTCTTTGTCTTGGCAAGAACCAGATCGTCCCAATGGAATCATCCTA
GAGTATGAAATCAAGTATTTTGAAAAGGACCAAGAGACCAGCTACACGATTATCAAATCT
AAAGAGACAACTATTACTGCAGAGGGCTTGAAACCAGCTTCAGTTTATGTCTTCCAAATT
CGAGCACGTACAGCAGCAGGCTATGGTGTCTTCAGTCGAAGATTTGAGTTTGAAACCACC
CCAGTGTTTGCAGCATCCAGCGATCAAAGCCAGATTCCTGTAATTGCTGTGTCTGTGACA
GTGGGAGTCATTTTGTTGGCAGTGGTTATCGGCGTCCTCCTCAGTGGAAGTTGCTGCGAA
TGTGGCTGTGGGAGGGCTTCTTCCCTGTGCGCTGTTGCCCATCCAAGCCTAATATGGCGG
TGTGGCTACAGCAAAGCAAAACAAGATCCAGAAGAGGAAAAGATGCATTTTCATAATGGG
CACATTAAACTGCCAGGAGTAAGAACTTACATTGATCCACATACCTATGAGGATCCCAAT
CAAGCTGTCCACGAATTTGCTAAGGAGATAGAAGCATCATGTATCACCATTGAGAGAGTT
ATTGGAGCAGGTGAATTTGGTGAAGTTTGTAGTGGACGTTTGAAACTACCAGGAAAAAGA
GAATTACCTGTGGCTATCAAAACCCTTAAAGTAGGCTATACTGAAAAGCAACGCAGAGAT
TTCCTAGGTGAAGCAAGTATCATGGGACAGTTTGATCATCCTAACATCATCCATTTAGAA
GGTGTGGTGACCAAAAGTAAACCAGTGATGATCGTGACAGAGTATATGGAGAATGGCTCT
TTAGATACATTTTTGAAGAAAAACGATGGGCAGTTCACTGTGATTCAGCTTGTTGGCATG
CTGAGAGGTATCTCTGCAGGAATGAAGTACCTTTCTGACATGGGCTATGTGCATAGAGAT
CTTGCTGCCAGAAACATCTTAATCAACAGTAACCTTGTGTGCAAAGTGTCTGACTTTGGA
CTTTCCCGGGTACTGGAAGATGATCCCGAGGCAGCCTACACCACAAGGGGAGGAAAAATT
CCAATCAGATGGACTGCCCCAGAAGCAATAGCTTTCCGAAAGTTTACTTCTGCCAGTGAT
GTCTGGAGTTATGGAATAGTAATGTGGGAAGTTGTGTCTTATGGAGAGAGACCCTACTGG
GAGATGACCAATCAAGATGTGATTAAAGCGGTAGAGGAAGGCTATCGTCTGCCAAGCCCC
ATGGATTGTCCTGCTGCTCTCTATCAGTTAATGCTGGATTGCTGGCAGAAAGAGCGAAAT
AGCAGGCCCAAGTTTGATGAAATAGTCAACATGTTGGACAAGCTGATACGTAACCCAAGT
AGTCTGAAGACGCTGGTTAATGCATCCTGCAGAGTATCTAATTTATTGGCAGAACATAGC
CCACTAGGATCTGGGGCCTACAGATCAGTAGGTGAATGGCTAGAGGCAATCAAGATGGGC
CGGTATACAGAGATTTTCATGGAAAATGGATACAGTTCAATGGACGCTGTGGCTCAGGTG
ACCTTGGAGGATTTGAGACGGCTTGGAGTGACTCTTGTCGGTCACCAGAAGAAGATCATG
AACAGCCTTCAAGAAATGAAGGTGCAGCTGGTAAACGGAATGGTGCCATTGTAA
Protein Properties
Number of Residues 1037
Molecular Weight 114802.3
Theoretical pI 6.92
Pfam Domain Function
Signals
  • 1-24
Transmembrane Regions
  • 574-594
Protein Sequence
>Ephrin type-A receptor 5
MRGSGPRGAGRRRPPSGGGDTPITPASLAGCYSAPRRAPLWTCLLLCAALRTLLASPSNE
VNLLDSRTVMGDLGWIAFPKNGWEEIGEVDENYAPIHTYQVCKVMEQNQNNWLLTSWISN
EGASRIFIELKFTLRDCNSLPGGLGTCKETFNMYYFESDDQNGRNIKENQYIKIDTIAAD
ESFTELDLGDRVMKLNTEVRDVGPLSKKGFYLAFQDVGACIALVSVRVYYKKCPSVVRHL
AVFPDTITGADSSQLLEVSGSCVNHSVTDEPPKMHCSAEGEWLVPIGKCMCKAGYEEKNG
TCQVCRPGFFKASPHIQSCGKCPPHSYTHEEASTSCVCEKDYFRRESDPPTMACTRPPSA
PRNAISNVNETSVFLEWIPPADTGGRKDVSYYIACKKCNSHAGVCEECGGHVRYLPRQSG
LKNTSVMMVDLLAHTNYTFEIEAVNGVSDLSPGARQYVSVNVTTNQAAPSPVTNVKKGKI
AKNSISLSWQEPDRPNGIILEYEIKYFEKDQETSYTIIKSKETTITAEGLKPASVYVFQI
RARTAAGYGVFSRRFEFETTPVFAASSDQSQIPVIAVSVTVGVILLAVVIGVLLSGSCCE
CGCGRASSLCAVAHPSLIWRCGYSKAKQDPEEEKMHFHNGHIKLPGVRTYIDPHTYEDPN
QAVHEFAKEIEASCITIERVIGAGEFGEVCSGRLKLPGKRELPVAIKTLKVGYTEKQRRD
FLGEASIMGQFDHPNIIHLEGVVTKSKPVMIVTEYMENGSLDTFLKKNDGQFTVIQLVGM
LRGISAGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKI
PIRWTAPEAIAFRKFTSASDVWSYGIVMWEVVSYGERPYWEMTNQDVIKAVEEGYRLPSP
MDCPAALYQLMLDCWQKERNSRPKFDEIVNMLDKLIRNPSSLKTLVNASCRVSNLLAEHS
PLGSGAYRSVGEWLEAIKMGRYTEIFMENGYSSMDAVAQVTLEDLRRLGVTLVGHQKKIM
NSLQEMKVQLVNGMVPL
GenBank ID Protein 221625401
UniProtKB/Swiss-Prot ID P54756
UniProtKB/Swiss-Prot Entry Name EPHA5_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_004439.5
GeneCard ID EPHA5
GenAtlas ID EPHA5
HGNC ID HGNC:3389
References
General References
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  3. Rikova K, Guo A, Zeng Q, Possemato A, Yu J, Haack H, Nardone J, Lee K, Reeves C, Li Y, Hu Y, Tan Z, Stokes M, Sullivan L, Mitchell J, Wetzel R, Macneill J, Ren JM, Yuan J, Bakalarski CE, Villen J, Kornhauser JM, Smith B, Li D, Zhou X, Gygi SP, Gu TL, Polakiewicz RD, Rush J, Comb MJ: Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer. Cell. 2007 Dec 14;131(6):1190-203. [PubMed:18083107 ]
  4. Bechtel S, Rosenfelder H, Duda A, Schmidt CP, Ernst U, Wellenreuther R, Mehrle A, Schuster C, Bahr A, Blocker H, Heubner D, Hoerlein A, Michel G, Wedler H, Kohrer K, Ottenwalder B, Poustka A, Wiemann S, Schupp I: The full-ORF clone resource of the German cDNA Consortium. BMC Genomics. 2007 Oct 31;8:399. [PubMed:17974005 ]
  5. Greenman C, Stephens P, Smith R, Dalgliesh GL, Hunter C, Bignell G, Davies H, Teague J, Butler A, Stevens C, Edkins S, O'Meara S, Vastrik I, Schmidt EE, Avis T, Barthorpe S, Bhamra G, Buck G, Choudhury B, Clements J, Cole J, Dicks E, Forbes S, Gray K, Halliday K, Harrison R, Hills K, Hinton J, Jenkinson A, Jones D, Menzies A, Mironenko T, Perry J, Raine K, Richardson D, Shepherd R, Small A, Tofts C, Varian J, Webb T, West S, Widaa S, Yates A, Cahill DP, Louis DN, Goldstraw P, Nicholson AG, Brasseur F, Looijenga L, Weber BL, Chiew YE, DeFazio A, Greaves MF, Green AR, Campbell P, Birney E, Easton DF, Chenevix-Trench G, Tan MH, Khoo SK, Teh BT, Yuen ST, Leung SY, Wooster R, Futreal PA, Stratton MR: Patterns of somatic mutation in human cancer genomes. Nature. 2007 Mar 8;446(7132):153-8. [PubMed:17344846 ]
  6. Miescher GC, Taylor V, Olivieri G, Mindermann T, Schrock E, Steck AJ: Extensive splice variation and localization of the EHK-1 receptor tyrosine kinase in adult human brain and glial tumors. Brain Res Mol Brain Res. 1997 Jun;46(1-2):17-24. [PubMed:9191074 ]
  7. Fox GM, Holst PL, Chute HT, Lindberg RA, Janssen AM, Basu R, Welcher AA: cDNA cloning and tissue distribution of five human EPH-like receptor protein-tyrosine kinases. Oncogene. 1995 Mar 2;10(5):897-905. [PubMed:7898931 ]