Hmdb loader
Identification
HMDB Protein ID HMDBP01214
Secondary Accession Numbers
  • 6510
Name Cell division protein kinase 17
Synonyms
  1. PCTAIRE-motif protein kinase 2
  2. Serine/threonine-protein kinase PCTAIRE-2
Gene Name CDK17
Protein Type Enzyme
Biological Properties
General Function Involved in protein kinase activity
Specific Function May play a role in terminally differentiated neurons. Has a Ser/Thr-phosphorylating activity for histone H1
Pathways Not Available
Reactions Not Available
GO Classification
Function
binding
catalytic activity
transferase activity
transferase activity, transferring phosphorus-containing groups
kinase activity
nucleoside binding
purine nucleoside binding
adenyl nucleotide binding
adenyl ribonucleotide binding
atp binding
protein kinase activity
protein serine/threonine kinase activity
Process
phosphorus metabolic process
phosphate metabolic process
metabolic process
cellular metabolic process
protein amino acid phosphorylation
phosphorylation
Cellular Location Not Available
Gene Properties
Chromosome Location Chromosome:1
Locus 12q23.1
SNPs CDK17
Gene Sequence
>1572 bp
ATGAAAAAATTTAAGAGAAGGCTATCCCTCACACTCCGAGGAAGTCAGACTATTGATGAA
TCATTGTCTGAATTGGCTGAACAAATGACTATTGAAGAAAACAGCAGCAAGGATAATGAG
CCTATTGTGAAGAATGGCAGGCCTCCAACGTCTCACAGTATGCATTCCTTCCTCCACCAG
TACACAGGATCTTTCAAGAAGCCCCCATTGCGGAGACCACACAGTGTTATTGGAGGGAGC
CTTGGCTCCTTCATGGCAATGCCCAGAAATGGAAGCAGATTAGATATTGTTCATGAAAAT
CTAAAAATGGGATCAGATGGTGAGAGTGACCAAGCTTCTGGGACATCATCTGATGAAGTC
CAGTCACCTACAGGTGTTTGTCTCAGAAATCGTATACATAGACGGATCTCAATGGAGGAT
TTAAATAAGCGGTTATCACTGCCTGCAGACATCAGAATACCTGATGGATATCTTGAAAAG
TTGCAGATAAACAGTCCACCATTTGACCAACCAATGAGTCGAAGGTCTCGTAGAGCTTCC
TTATCAGAAATTGGCTTTGGAAAAATGGAAACCTACATCAAATTGGAAAAGCTTGGAGAG
GGTACATATGCAACAGTATATAAAGGAAGAAGTAAATTGACAGAGAATTTGGTGGCATTA
AAAGAGATCCGATTGGAACATGAAGAAGGTGCACCCTGCACAGCTATAAGAGAAGTTTCA
CTATTAAAGGATTTAAAACATGCAAATATAGTAACCTTACATGACATTGTTCACACAGAT
AAATCCTTGACTTTGGTGTTTGAGTATCTGGATAAAGACCTGAAACAGTACATGGATGAC
TGTGGAAACATCATGAGTATGCACAACGTAAAGCTGTTTCTGTACCAAATTCTACGTGGT
TTGGCATATTGCCATAGAAGAAAGGTATTGCATCGAGACTTGAAACCACAGAACCTCCTC
ATTAATGAGAAAGGAGAATTAAAGCTAGCAGATTTTGGACTAGCCCGAGCCAAGTCAGTT
CCCACAAAGACCTACTCAAATGAAGTTGTCACACTATGGTACCGGCCACCTGATGTGCTT
CTTGGTTCCTCGGAGTACTTAACACAGATTGACATGTGGGGTGTTGGTTGCATTTTCTTT
GAAATGGCTTCTGGAAGACCTTTATTTCCAGGATCAACCGTGGAAGATGAACTGCACTTA
ATTTTCCGACTGCTAGGAACTCCATCTCAGGAAACTTGGCCAGGTATTTCTTCAAATGAG
GAGTTCAAGAACTACAACTTTCCAAAATATAAACCAGAGCCTCTAATTAACCACGCACCC
AGGTTAGACTCTGAAGGAATTGAGTTGATAAGAAAATTTCTTCAGTATGAATCTAAGAAA
AGGGTTTCAGCTGAAGAGGCCATGAAACATGTGTACTTTCGAAGTCTGGGACCAAGAATA
CATGCTTTACCAGAAAGTGTATCAATATTCAGTTTGAAAGAGATTCAGTTGCAAAAGGAC
CCGGGTTTTCGAAATTCTTCTTATCCAGAGACAGGACATGGGAAGAACAGAAGACAGAGC
ATGCTCTTTTAA
Protein Properties
Number of Residues 523
Molecular Weight 59581.7
Theoretical pI 9.44
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • None
Protein Sequence
>Cell division protein kinase 17
MKKFKRRLSLTLRGSQTIDESLSELAEQMTIEENSSKDNEPIVKNGRPPTSHSMHSFLHQ
YTGSFKKPPLRRPHSVIGGSLGSFMAMPRNGSRLDIVHENLKMGSDGESDQASGTSSDEV
QSPTGVCLRNRIHRRISMEDLNKRLSLPADIRIPDGYLEKLQINSPPFDQPMSRRSRRAS
LSEIGFGKMETYIKLEKLGEGTYATVYKGRSKLTENLVALKEIRLEHEEGAPCTAIREVS
LLKDLKHANIVTLHDIVHTDKSLTLVFEYLDKDLKQYMDDCGNIMSMHNVKLFLYQILRG
LAYCHRRKVLHRDLKPQNLLINEKGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVL
LGSSEYSTQIDMWGVGCIFFEMASGRPLFPGSTVEDELHLIFRLLGTPSQETWPGISSNE
EFKNYNFPKYKPQPLINHAPRLDSEGIELITKFLQYESKKRVSAEEAMKHVYFRSLGPRI
HALPESVSIFSLKEIQLQKDPGFRNSSYPETGHGKNRRQSMLF
GenBank ID Protein 36617
UniProtKB/Swiss-Prot ID Q00537
UniProtKB/Swiss-Prot Entry Name CDK17_HUMAN
PDB IDs Not Available
GenBank Gene ID X66360
GeneCard ID CDK17
GenAtlas ID CDK17
HGNC ID HGNC:8750
References
General References
  1. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [PubMed:14702039 ]
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  3. Dephoure N, Zhou C, Villen J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP: A quantitative atlas of mitotic phosphorylation. Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10762-7. doi: 10.1073/pnas.0805139105. Epub 2008 Jul 31. [PubMed:18669648 ]
  4. Mayya V, Lundgren DH, Hwang SI, Rezaul K, Wu L, Eng JK, Rodionov V, Han DK: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. Sci Signal. 2009 Aug 18;2(84):ra46. doi: 10.1126/scisignal.2000007. [PubMed:19690332 ]
  5. Daub H, Olsen JV, Bairlein M, Gnad F, Oppermann FS, Korner R, Greff Z, Keri G, Stemmann O, Mann M: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. Mol Cell. 2008 Aug 8;31(3):438-48. doi: 10.1016/j.molcel.2008.07.007. [PubMed:18691976 ]
  6. Oppermann FS, Gnad F, Olsen JV, Hornberger R, Greff Z, Keri G, Mann M, Daub H: Large-scale proteomics analysis of the human kinome. Mol Cell Proteomics. 2009 Jul;8(7):1751-64. doi: 10.1074/mcp.M800588-MCP200. Epub 2009 Apr 15. [PubMed:19369195 ]
  7. Gauci S, Helbig AO, Slijper M, Krijgsveld J, Heck AJ, Mohammed S: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. Anal Chem. 2009 Jun 1;81(11):4493-501. doi: 10.1021/ac9004309. [PubMed:19413330 ]
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  9. Meyerson M, Enders GH, Wu CL, Su LK, Gorka C, Nelson C, Harlow E, Tsai LH: A family of human cdc2-related protein kinases. EMBO J. 1992 Aug;11(8):2909-17. [PubMed:1639063 ]
  10. Wissing J, Jansch L, Nimtz M, Dieterich G, Hornberger R, Keri G, Wehland J, Daub H: Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry. Mol Cell Proteomics. 2007 Mar;6(3):537-47. Epub 2006 Dec 27. [PubMed:17192257 ]