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Identification
HMDB Protein ID HMDBP01226
Secondary Accession Numbers
  • 6522
Name Plasma membrane calcium-transporting ATPase 2
Synonyms
  1. PMCA2
  2. Plasma membrane calcium ATPase isoform 2
  3. Plasma membrane calcium pump isoform 2
Gene Name ATP2B2
Protein Type Unknown
Biological Properties
General Function Involved in ATP binding
Specific Function This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell.
Pathways
  • Calcium signaling pathway
  • Pancreatic secretion
  • Salivary secretion
Reactions Not Available
GO Classification
Biological Process
sensory perception of sound
locomotory behavior
neuromuscular process controlling balance
ATP biosynthetic process
locomotion
blood coagulation
auditory receptor cell stereocilium organization
cerebellar granule cell differentiation
cerebellar Purkinje cell differentiation
cGMP metabolic process
cochlea development
cytosolic calcium ion homeostasis
detection of mechanical stimulus involved in sensory perception of sound
neural retina development
organelle organization
otolith mineralization
positive regulation of calcium ion transport
regulation of cell size
regulation of synaptic plasticity
synapse organization
serotonin metabolic process
neuron differentiation
lactation
Cellular Component
cilium
membrane raft
cytoplasm
endoplasmic reticulum
plasma membrane
dendrite
neuronal cell body
apical plasma membrane
integral to membrane
Component
membrane
cell part
Function
di-, tri-valent inorganic cation transmembrane transporter activity
calcium ion transmembrane transporter activity
calcium-transporting atpase activity
binding
catalytic activity
hydrolase activity
nucleoside binding
purine nucleoside binding
adenyl nucleotide binding
adenyl ribonucleotide binding
atp binding
transmembrane transporter activity
substrate-specific transmembrane transporter activity
ion transmembrane transporter activity
cation transmembrane transporter activity
inorganic cation transmembrane transporter activity
transporter activity
atpase activity, coupled to transmembrane movement of ions
atpase activity, coupled to transmembrane movement of ions, phosphorylative mechanism
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
hydrolase activity, acting on acid anhydrides
Molecular Function
metal ion binding
ATP binding
calcium-transporting ATPase activity
calcium-dependent ATPase activity
PDZ domain binding
calcium ion binding
calmodulin binding
Process
purine nucleotide metabolic process
purine nucleotide biosynthetic process
purine nucleoside triphosphate biosynthetic process
purine ribonucleoside triphosphate biosynthetic process
di-, tri-valent inorganic cation transport
divalent metal ion transport
calcium ion transport
metabolic process
nitrogen compound metabolic process
cellular nitrogen compound metabolic process
nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
nucleobase, nucleoside and nucleotide metabolic process
nucleoside phosphate metabolic process
nucleotide metabolic process
establishment of localization
transport
ion transport
atp biosynthetic process
cation transport
Cellular Location
  1. Cell membrane
  2. Multi-pass membrane protein
Gene Properties
Chromosome Location 3
Locus 3p25.3
SNPs ATP2B2
Gene Sequence
>3732 bp
ATGGGTGACATGACCAACAGCGACTTTTACTCCAAAAACCAAAGAAATGAGTCGAGCCAT
GGGGGCGAGTTCGGGTGCACAATGGAGGAGCTCCGCTCCCTCATGGAGCTGCGGGGCACT
GAGGCTGTGGTCAAGATCAAGGAGACTTATGGGGACACCGAAGCCATCTGCCGGCGCCTC
AAAACCTCACCTGTTGAAGGTTTGCCGGGCACCGCTCCAGACCTGGAAAAGAGAAAGCAA
ATTTTTGGGCAAAACTTTATACCTCCAAAGAAGCCAAAAACCTTCCTGCAGCTCGTGTGG
GAGGCGCTGCAGGACGTGACGCTCATCATCCTGGAGATTGCCGCCATCATCTCCCTGGGG
CTGTCCTTCTACCACCCGCCCGGCGAGGGCAACGAAGGATGTGCGACGGCCCAGGGTGGG
GCAGAGGATGAAGGAGAGGCAGAGGCAGGTTGGATCGAGGGGGCCGCCATTCTCCTCTCA
GTTATCTGTGTGGTCCTGGTCACGGCCTTCAATGACTGGAGCAAAGAGAAACAGTTCCGG
GGCCTGCAGAGCCGCATCGAGCAGGAACAGAAATTTACCGTGGTCCGGGCTGGCCAGGTG
GTCCAGATCCCTGTGGCTGAGATCGTGGTTGGGGACATAGCCCAGGTCAAATATGGTGAC
CTCCTCCCTGCCGACGGCCTCTTCATCCAGGGCAATGACCTCAAGATTGATGAAAGCTCC
CTAACTGGAGAGTCTGACCAGGTGCGCAAGTCCGTGGACAAGGACCCCATGCTGCTGTCA
GGAACCCACGTGATGGAGGGCTCAGGACGGATGTTGGTGACTGCTGTGGGTGTGAACTCT
CAGACTGGCATCATCTTTACCCTCCTGGGGGCTGGTGGTGAAGAGGAAGAGAAGAAAGAC
AAAAAAGGTGTGAAGAAGGGGGATGGCCTTCAGCTACCAGCAGCAGACGGTGCGGCAGCT
TCAAATGCTGCAGATAGTGCGAATGCCAGCCTAGTCAATGGTAAAATGCAGGATGGCAAT
GTGGACGCCAGCCAGAGCAAAGCCAAACAACAGGACGGGGCAGCCGCCATGGAGATGCAG
CCCCTCAAGAGTGCCGAGGGCGGCGACGCTGACGACAGGAAGAAGGCCAGCATGCACAAG
AAGGAGAAGTCCGTGCTGCAGGGCAAGCTCACCAAGCTGGCTGTGCAGATCGGGAAGGCG
GGCTTGGTGATGTCAGCCATCACGGTGATCATCCTGGTGCTCTACTTCACTGTGGACACC
TTCGTGGTCAACAAGAAGCCGTGGCTGCCTGAGTGCACGCCCGTCTACGTGCAGTACTTT
GTCAAGTTCTTCATCATTGGCGTGACGGTGCTGGTGGTCGCCGTGCCCGAGGGGCTCCCT
CTGGCCGTCACCATCTCGTTGGCCTATTCGGTGAAGAAAATGATGAAGGACAACAACCTG
GTACGCCACCTGGATGCCTGTGAGACCATGGGCAATGCCACAGCCATCTGCTCAGACAAG
ACAGGCACGCTGACCACCAATCGCATGACAGTGGTACAGGCCTATGTCGGCGACGTCCAC
TATAAAGAGATCCCCGACCCCAGCTCCATCAACACCAAGACCATGGAGCTGCTGATCAAT
GCCATCGCCATCAACAGCGCCTACACCACCAAGATTCTGCCCCCAGAGAAGGAGGGCGCC
CTGCCTCGGCAGGTGGGCAACAAGACGGAGTGCGGCCTGCTGGGCTTCGTGCTGGACCTG
AAGCAGGACTACGAGCCCGTGCGCAGCCAGATGCCAGAGGAGAAGTTGTACAAAGTGTAC
ACCTTCAACTCCGTGCGCAAGTCCATGAGCACTGTCATCAAGCTGCCCGACGAGAGCTTC
CGCATGTACAGCAAGGGGGCTTCTGAGATCGTGCTCAAGAAGTGCTGCAAAATCCTCAAT
GGGGCGGGAGAGCCTCGTGTCTTCCGGCCCCGCGACCGGGACGAGATGGTAAAGAAGGTG
ATTGAGCCCATGGCTTGCGATGGGCTCCGCACTATCTGCGTGGCCTACCGCGACTTCCCC
AGCAGCCCGGAGCCGGACTGGGACAATGAGAATGACATCCTCAACGAACTCACCTGCATC
TGCGTGGTGGGCATCGAGGACCCGGTGCGGCCAGAGGTCCCAGAAGCCATCCGCAAGTGC
CAGCGGGCAGGCATCACGGTCCGCATGGTCACTGGCGACAATATCAACACGGCTCGGGCC
ATCGCCATCAAGTGTGGCATCATCCATCCTGGGGAGGACTTTCTGTGCCTCGAGGGCAAG
GAGTTCAACAGGAGGATCCGCAACGAGAAGGGGGAGATTGAGCAGGAGCGAATTGACAAG
ATCTGGCCAAAGCTGCGGGTGCTGGCTCGCTCCTCCCCAACGGACAAGCATACCCTGGTT
AAAGGCATCATCGACAGCACACACACTGAGCAGCGGCAGGTGGTGGCCGTGACGGGGGAC
GGGACCAACGACGGGCCTGCACTCAAGAAGGCCGACGTGGGCTTCGCCATGGGCATCGCA
GGCACTGACGTGGCCAAGGAGGCCTCAGACATCATCCTGACAGACGACAATTTCAGCAGC
ATCGTCAAGGCAGTGATGTGGGGCCGCAACGTCTATGACAGCATCTCCAAATTCTTGCAG
TTCCAGCTCACCGTCAACGTGGTGGCCGTGATTGTGGCCTTCACAGGCGCCTGCATCACG
CAGGACTCCCCTCTGAAGGCCGTGCAGATGCTCTGGGTGAACCTCATCATGGACACGTTT
GCCTCGCTGGCACTGGCCACTGAGCCGCCCACGGAGACCCTGCTGCTGAGGAAGCCGTAC
GGCCGCAACAAGCCGCTCATCTCCAGGACCATGATGAAGAACATCCTGGGCCATGCTGTC
TACCAGCTTGCCCTCATCTTCACCCTGCTCTTTGTTGGCGAGAAGATGTTCCAGATCGAC
AGCGGGAGGAACGCGCCCCTGCATTCGCCACCCTCAGAACATTACACCATCATCTTCAAC
ACCTTCGTCATGATGCAGCTCTTCAACGAGATCAACGCCCGCAAGATCCACGGCGAGCGC
AATGTCTTTGACGGCATCTTCCGGAACCCCATCTTCTGCACCATCGTGCTGGGCACCTTT
GCCATCCAGATAGTGATCGTGCAGTTTGGAGGGAAGCCATTCAGCTGCTCTCCACTGCAG
CTGGACCAGTGGATGTGGTGCATATTCATTGGGTTAGGAGAGCTCGTTTGGGGCCAGGTC
ATCGCCACCATCCCGACCAGCAGACTCAAGTTCCTCAAGGAGGCAGGCAGGCTCACACAG
AAGGAGGAGATCCCGGAGGAGGAGCTCAACGAGGACGTGGAGGAGATCGACCACGCGGAG
CGGGAGCTGCGGCGGGGCCAGATCCTGTGGTTCCGAGGCCTGAATCGGATCCAGACACAG
ATCCGCGTCGTGAAGGCGTTCCGTAGCTCTCTCTATGAAGGTTTAGAAAAGCCTGAATCT
CGAACCTCCATCCATAACTTCATGGCTCATCCTGAATTCCGGATCGAAGATTCCCAGCCC
CACATCCCCCTCATTGATGACACCGACCTGGAAGAAGATGCCGCGCTCAAGCAGAACTCG
AGCCCGCCGTCATCCCTCAACAAGAACAACAGCGCCATCGACAGTGGGATCAACCTGACG
ACCGACACAAGCAAATCAGCTACCTCTTCAAGTCCAGGGAGCCCCATCCACAGCCTGGAG
ACGTCGCTTTAG
Protein Properties
Number of Residues 1243
Molecular Weight 136875.18
Theoretical pI 5.911
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>Plasma membrane calcium-transporting ATPase 2
MGDMTNSDFYSKNQRNESSHGGEFGCTMEELRSLMELRGTEAVVKIKETYGDTEAICRRL
KTSPVEGLPGTAPDLEKRKQIFGQNFIPPKKPKTFLQLVWEALQDVTLIILEIAAIISLG
LSFYHPPGEGNEGCATAQGGAEDEGEAEAGWIEGAAILLSVICVVLVTAFNDWSKEKQFR
GLQSRIEQEQKFTVVRAGQVVQIPVAEIVVGDIAQVKYGDLLPADGLFIQGNDLKIDESS
LTGESDQVRKSVDKDPMLLSGTHVMEGSGRMLVTAVGVNSQTGIIFTLLGAGGEEEEKKD
KKGVKKGDGLQLPAADGAAASNAADSANASLVNGKMQDGNVDASQSKAKQQDGAAAMEMQ
PLKSAEGGDADDRKKASMHKKEKSVLQGKLTKLAVQIGKAGLVMSAITVIILVLYFTVDT
FVVNKKPWLPECTPVYVQYFVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNL
VRHLDACETMGNATAICSDKTGTLTTNRMTVVQAYVGDVHYKEIPDPSSINTKTMELLIN
AIAINSAYTTKILPPEKEGALPRQVGNKTECGLLGFVLDLKQDYEPVRSQMPEEKLYKVY
TFNSVRKSMSTVIKLPDESFRMYSKGASEIVLKKCCKILNGAGEPRVFRPRDRDEMVKKV
IEPMACDGLRTICVAYRDFPSSPEPDWDNENDILNELTCICVVGIEDPVRPEVPEAIRKC
QRAGITVRMVTGDNINTARAIAIKCGIIHPGEDFLCLEGKEFNRRIRNEKGEIEQERIDK
IWPKLRVLARSSPTDKHTLVKGIIDSTHTEQRQVVAVTGDGTNDGPALKKADVGFAMGIA
GTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACIT
QDSPLKAVQMLWVNLIMDTFASLALATEPPTETLLLRKPYGRNKPLISRTMMKNILGHAV
YQLALIFTLLFVGEKMFQIDSGRNAPLHSPPSEHYTIIFNTFVMMQLFNEINARKIHGER
NVFDGIFRNPIFCTIVLGTFAIQIVIVQFGGKPFSCSPLQLDQWMWCIFIGLGELVWGQV
IATIPTSRLKFLKEAGRLTQKEEIPEEELNEDVEEIDHAERELRRGQILWFRGLNRIQTQ
IRVVKAFRSSLYEGLEKPESRTSIHNFMAHPEFRIEDSQPHIPLIDDTDLEEDAALKQNS
SPPSSLNKNNSAIDSGINLTTDTSKSATSSSPGSPIHSLETSL
GenBank ID Protein 48255951
UniProtKB/Swiss-Prot ID Q01814
UniProtKB/Swiss-Prot Entry Name AT2B2_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_001001331.2
GeneCard ID ATP2B2
GenAtlas ID ATP2B2
HGNC ID HGNC:815
References
General References
  1. Dephoure N, Zhou C, Villen J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP: A quantitative atlas of mitotic phosphorylation. Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10762-7. doi: 10.1073/pnas.0805139105. Epub 2008 Jul 31. [PubMed:18669648 ]
  2. Gauci S, Helbig AO, Slijper M, Krijgsveld J, Heck AJ, Mohammed S: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. Anal Chem. 2009 Jun 1;81(11):4493-501. doi: 10.1021/ac9004309. [PubMed:19413330 ]
  3. Stauffer TP, Hilfiker H, Carafoli E, Strehler EE: Quantitative analysis of alternative splicing options of human plasma membrane calcium pump genes. J Biol Chem. 1993 Dec 5;268(34):25993-6003. [PubMed:8245032 ]
  4. Stauffer TP, Hilfiker H, Carafoli E, Strehler EE: Quantitative analysis of alternative splicing options of human plasma membrane calcium pump genes. J Biol Chem. 1994 Dec 16;269(50):32022. [PubMed:7989379 ]
  5. Brandt P, Ibrahim E, Bruns GA, Neve RL: Determination of the nucleotide sequence and chromosomal localization of the ATP2B2 gene encoding human Ca(2+)-pumping ATPase isoform PMCA2. Genomics. 1992 Oct;14(2):484-7. [PubMed:1427863 ]
  6. Latif F, Duh FM, Gnarra J, Tory K, Kuzmin I, Yao M, Stackhouse T, Modi W, Geil L, Schmidt L, et al.: von Hippel-Lindau syndrome: cloning and identification of the plasma membrane Ca(++)-transporting ATPase isoform 2 gene that resides in the von Hippel-Lindau gene region. Cancer Res. 1993 Feb 15;53(4):861-7. [PubMed:8428366 ]
  7. Heim R, Hug M, Iwata T, Strehler EE, Carafoli E: Microdiversity of human-plasma-membrane calcium-pump isoform 2 generated by alternative RNA splicing in the N-terminal coding region. Eur J Biochem. 1992 Apr 1;205(1):333-40. [PubMed:1313367 ]