Hmdb loader

Showing Protein Dual specificity tyrosine-phosphorylation-regulated kinase 1B (HMDBP01233)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 2 metabolites
Identification
HMDB Protein ID HMDBP01233
Secondary Accession Numbers
  • 6529
Name Dual specificity tyrosine-phosphorylation-regulated kinase 1B
Synonyms
  1. Minibrain-related kinase
  2. Mirk protein kinase
Gene Name DYRK1B
Protein Type Enzyme
Biological Properties
General Function Involved in protein kinase activity
Specific Function Dual-specificity kinase which possesses both serine/ threonine and tyrosine kinase activities. Enhances the transcriptional activity of TCF1/HNF1A and FOXO1. Inhibits epithelial cell migration. Mediates colon carcinoma cell survival in mitogen-poor environments
Pathways Not Available
Reactions Not Available
GO Classification
Function
binding
catalytic activity
transferase activity
transferase activity, transferring phosphorus-containing groups
kinase activity
nucleoside binding
purine nucleoside binding
adenyl nucleotide binding
adenyl ribonucleotide binding
atp binding
protein kinase activity
protein serine/threonine kinase activity
Process
phosphorus metabolic process
phosphate metabolic process
metabolic process
cellular metabolic process
protein amino acid phosphorylation
phosphorylation
Cellular Location
  1. Nucleus
Gene Properties
Chromosome Location Chromosome:1
Locus 19q12-q13.1
SNPs DYRK1B
Gene Sequence 
>1890 bp
ATGGCCGTCCCACCGGGCCATGGTCCCTTCTCTGGCTTCCCAGGGCCCCAGGAGCACACG
CAGGTATTGCCTGATGTGCGGCTACTGCCTCGGAGGCTGCCCCTGGCCTTCCGGGATGCA
ACCTCAGCCCCGCTGCGTAAGCTCTCTGTGGACCTCATCAAGACCTACAAGCACATCAAT
GAGGTATACTATGCGAAGAAGAAGCGGCGGGCCCAGCAGGCGCCACCCCAGGATTCGAGC
AACAAGAAGGAGAAGAAGGTCCTGAACCATGGTTATGATGACGACAACCATGACTACATC
GTGCGCAGTGGCGAGCGCTGGCTGGAGCGCTACGAAATTGACTCGCTCATTGGCAAAGGC
TCCTTTGGCCAGGTGGTGAAAGCCTATGATCATCAGACCCAGGAGCTTGTGGCCATCAAG
ATCATCAAGAACAAAAAGGCTTTCCTGAACCAGGCCCAGATTGAGCTGCGGCTGCTGGAG
CTGATGAACCAGCATGACACGGAGATGAAGTACTATATAGTACACCTGAAGCGGCACTTC
ATGTTCCGGAACCACCTGTGCCTGGTATTTGAGCTGCTGTCCTACAACCTGTACGACCTC
CTGCGCAACACCCACTTCCGCGGCGTCTCGCTGAACCTGACCCGGAAGCTGGCGCAGCAG
CTCTGCACGGCACTGCTCTTTCTGGCCACGCCTGAGCTCAGCATCATTCACTGCGACCTC
AAGCCCGAAAACATCTTGCTGTGCAACCCCAAGCGCAGCGCCATCAAGATTGTGGACTTC
GGCAGCTCCTGCCAGCTTGGCCAGAGGATCTACCAGTATATCCAGAGCCGCTTCTACCGC
TCACCTGAGGTGCTCCTGGGCACACCCTACGACCTGGCCATTGACATGTGGTCCCTGGGC
TGCATCCTTGTGGAGATGCACACCGGAGAGCCCCTCTTCAGTGGCTCCAATGAGGTCGAC
CAGATGAACCGCATTGTGGAGGTGCTGGGCATCCCACCGGCCGCCATGCTGGACCAGGCG
CCCAAGGCTCGCAAGTACTTTGAACGGCTGCCTGGGGGTGGCTGGACCCTACGAAGGACG
AAAGAACTCAGGAAGGATTACCAGGGCCCCGGGACACGGCGGCTGCAGGAGGTGCTGGGC
GTGCAGACGGGCGGGCCCGGGGGCCGGCGGGCGGGGGAGCCGGGCCACAGCCCCGCCGAC
TACCTCCGCTTCCAGGACCTGGTGCTGCGCATGCTGGAGTATGAGCCCGCCGCCCGCATC
AGCCCCCTGGGGGCTCTGCAGCACGGCTTCTTCCGCCGCACGGCCGACGAGGCCACCAAC
ACGGGCCCGGCAGGCAGCAGTGCCTCCACCTCGCCCGCGCCCCTCGACACCTGCCCCTCT
TCCAGCACCGCCAGCTCCATCTCCAGTTCTGGAGGCTCCAGTGGCTCCTCCAGTGACAAC
CGGACCTACCGCTACAGCAACCGATATTGTGGGGGCCCTGGGCCCCCTATCACAGACTGT
GAGATGAACAGCCCCCAGGTCCCACCCTCCCAGCCGCTGCGGCCCTGGGCAGGGGGTGAT
GTGCCCCACAAGACACATCAAGCCCCTGCCTCTGCCTCGTCACTGCCTGGGACCGGGGCC
CAGTTACCCCCCCAGCCCCGATACCTTGGTCGTCCCCCATCACCAACCTCACCACCACCC
CCGGAGCTGATGGATGTGAGCCTGGTGGGCGGCCCTGCTGACTGCTCCCCACCTCACCCA
GCGCCTGCCCCCCAGCACCCGGCTGCCTCAGCCCTCCGGACTCGGATGACTGGAGGTCGT
CCACCCCTCCCGCCTCCTGATGACCCTGCCACTCTGGGGCCTCACCTGGGCCTCCGTGGT
GTACCCCAGAGCACAGCAGCCAGCTCGTGA
Protein Properties
Number of Residues 629
Molecular Weight 69197.2
Theoretical pI 9.43
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • None
Protein Sequence 
>Dual specificity tyrosine-phosphorylation-regulated kinase 1B
MAVPPGHGPFSGFPGPQEHTQVLPDVRLLPRRLPLAFRDATSAPLRKLSVDLIKTYKHIN
EVYYAKKKRRAQQAPPQDSSNKKEKKVLNHGYDDDNHDYIVRSGERWLERYEIDSLIGKG
SFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMKYYIVHLKRHF
MFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLATPELSIIHCDL
KPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGTPYDLAIDMWSLG
CILVEMHTGEPLFSGSNEVDQMNRIVEVLGIPPAAMLDQAPKARKYFERLPGGGWTLRRT
KELRKDYQGPGTRRLQEVLGVQTGGPGGRRAGEPGHSPADYLRFQDLVLRMLEYEPAARI
SPLGALQHGFFRRTADEATNTGPAGSSASTSPAPLDTCPSSSTASSISSSGGSSGSSSDN
RTYRYSNRYCGGPGPPITDCEMNSPQVPPSQPLRPWAGGDVPHKTHQAPASASSLPGTGA
QLPPQPRYLGRPPSPTSPPPPELMDVSLVGGPADCSPPHPAPAPQHPAASALRTRMTGGR
PPLPPPDDPATLGPHLGLRGVPQSTAASS
GenBank ID Protein 6538760
UniProtKB/Swiss-Prot ID Q9Y463
UniProtKB/Swiss-Prot Entry Name DYR1B_HUMAN
PDB IDs Not Available
GenBank Gene ID AF205861
GeneCard ID DYRK1B
GenAtlas ID DYRK1B
HGNC ID HGNC:3092
References
General References
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  5. Zahedi RP, Lewandrowski U, Wiesner J, Wortelkamp S, Moebius J, Schutz C, Walter U, Gambaryan S, Sickmann A: Phosphoproteome of resting human platelets. J Proteome Res. 2008 Feb;7(2):526-34. Epub 2007 Dec 19. [PubMed:18088087 ]
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  12. Lee K, Deng X, Friedman E: Mirk protein kinase is a mitogen-activated protein kinase substrate that mediates survival of colon cancer cells. Cancer Res. 2000 Jul 1;60(13):3631-7. [PubMed:10910078 ]
  13. Lim S, Jin K, Friedman E: Mirk protein kinase is activated by MKK3 and functions as a transcriptional activator of HNF1alpha. J Biol Chem. 2002 Jul 12;277(28):25040-6. Epub 2002 Apr 29. [PubMed:11980910 ]
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  15. Skurat AV, Dietrich AD: Phosphorylation of Ser640 in muscle glycogen synthase by DYRK family protein kinases. J Biol Chem. 2004 Jan 23;279(4):2490-8. Epub 2003 Oct 30. [PubMed:14593110 ]