Hmdb loader
Identification
HMDB Protein ID HMDBP01285
Secondary Accession Numbers
  • 6581
Name Serine/threonine-protein kinase 35
Synonyms
  1. CLIK-1
  2. CLP-36-interacting kinase 1
  3. PDLIM1-interacting kinase 1
  4. Serine/threonine-protein kinase 35 L1
Gene Name STK35
Protein Type Enzyme
Biological Properties
General Function Involved in protein kinase activity
Specific Function ATP + a protein = ADP + a phosphoprotein
Pathways Not Available
Reactions Not Available
GO Classification
Function
binding
catalytic activity
transferase activity
transferase activity, transferring phosphorus-containing groups
kinase activity
nucleoside binding
purine nucleoside binding
adenyl nucleotide binding
adenyl ribonucleotide binding
atp binding
protein kinase activity
protein serine/threonine kinase activity
Process
phosphorus metabolic process
phosphate metabolic process
metabolic process
cellular metabolic process
protein amino acid phosphorylation
phosphorylation
Cellular Location
  1. Nucleus
  2. Nucleus
  3. Cytoplasm
  4. nucleolus
Gene Properties
Chromosome Location Chromosome:2
Locus 20p13
SNPs STK35
Gene Sequence
>1605 bp
ATGGGCCACCAGGAGTCTCCGCTGGCCCGGGCGCCGGCGGGAGGTGCAGCTTATGTAAAG
AGGTTATGTAAAGGGCTCAGCTGGCGCGAACACGTGGAAAGCCACGGGAGCCTAGGAGCC
CAGGCTTCCCCAGCGAGCGCCGCGGCAGCAGAAGGATCCGCTACACGCCGGGCTCGGGCC
GCCACCTCCCGCGCTGCTCGGTCCCGGAGGCAGCCCGGGCCCGGAGCGGACCATCCCCAG
GCAGGGGCTCCAGGGGGGAAACGGGCCGCCCGGAAGTGGAGGTGCGCGGGCCAGGTCACA
ATCCAAGGTCCGGCTCCTCCGCGTCCCAGGGCCGGACGGAGGGATGAGGCAGGGGGGGCC
CGGGCAGCGCCGTTGCTGCTCCCCCCGCCGCCCGCAGCCATGGAAACGGGGAAGGACGGC
GCCCGCAGAGGTACACAAAGCCCGGAGCGGAAAAGGCGAAGCCCAGTGCCGCGGGCGCCC
AGCACGAAGCTGAGGCCGGCGGCGGCGGCCCGGGCCATGGATCCGGTGGCGGCCGAGGCC
CCGGGCGAGGCCTTCCTGGCGCGGCGACGGCCTGAGGGCGGTGGCGGGTCCGCGCGGCCG
CGTTACAGCCTGTTGGCGGAGATCGGGCGCGGCAGCTACGGCGTGGTTTATGAGGCAGTG
GCCGGGCGCAGCGGGGCCCGGGTGGCGGTCAAGAAGATCCGCTGCGACGCCCCCGAGAAC
GTGGAGCTGGCGCTGGCTGAATTCTGGGCCCTCACCAGCCTCAAGCGGCGCCACCAGAAC
GTCGTGCAGTTTGAGGAGTGCGTCCTGCAGCGCAATGGGTTAGCCCAGCGCATGAGTCAC
GGCAACAAGAGCTCGCAGCTTTACCTGCGCCTGGTGGAGACCTCGCTGAAAGGAGAAAGG
ATCCTGGGTTATGCTGAGGAGCCCTGCTATCTCTGGTTTGTCATGGAGTTCTGTGAAGGT
GGAGACCTGAATCAGTATGTCCTGTCCCGGAGGCCAGACCCAGCCACCAACAAAAGTTTC
ATGCTACAGCTGACGAGCGCCATTGCCTTCCTGCACAAAAACCATATTGTGCACAGGGAC
CTGAAGCCAGACAACATCCTCATCACAGAGCGGTCTGGCACCCCCATCCTCAAAGTGGCC
GACTTTGGACTAAGCAAGGTCTGTGCTGGGCTGGCACCCCGAGGCAAAGAGGGCAATCAA
GACAACAAAAATGTGAATGTGAATAAGTACTGGCTGTCCTCAGCCTGCGGTTCGGACTTC
TACATGGCTCCTGAAGTCTGGGAGGGACACTACACAGCCAAGGCGGACATCTTTGCCCTG
GGCATTATCATCTGGGCAATGATAGAAAGAATCACTTTTATTGACTCTGAGACCAAGAAG
GAGCTCCTGGGGACCTACATTAAACAGGGGACTGAGATCGTCCCTGTTGGTGAGGCGCTG
CTAGAAAACCCAAAGATGGAGTTGCACATCCCCCAAAAACGCAGGACTTCCATGTCTGAG
GGGATCAAGCAGCTCTTGAAAGATATGTTAGCTGCTAACCCACAGGACCGGCCTGATGCC
TTTGAACTTGAAACCAGAATGGACCAGGTCACATGTGCTGCTTAA
Protein Properties
Number of Residues 534
Molecular Weight 58050.8
Theoretical pI 10.29
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • None
Protein Sequence
>Serine/threonine-protein kinase 35
MGHQESPLARAPAGGAAYVKRLCKGLSWREHVESHGSLGAQASPASAAAAEGSATRRARA
ATSRAARSRRQPGPGADHPQAGAPGGKRAARKWRCAGQVTIQGPAPPRPRAGRRDEAGGA
RAAPLLLPPPPAAMETGKDGARRGTQSPERKRRSPVPRAPSTKLRPAAAARAMDPVAAEA
PGEAFLARRRPEGGGGSARPRYSLLAEIGRGSYGVVYEAVAGRSGARVAVKKIRCDAPEN
VELALAEFWALTSLKRRHQNVVQFEECVLQRNGLAQRMSHGNKSSQLYLRLVETSLKGER
ILGYAEEPCYLWFVMEFCEGGDLNQYVLSRRPDPATNKSFMLQLTSAIAFLHKNHIVHRD
LKPDNILITERSGTPILKVADFGLSKVCAGLAPRGKEGNQDNKNVNVNKYWLSSACGSDF
YMAPEVWEGHYTAKADIFALGIIIWAMIERITFIDSETKKELLGTYIKQGTEIVPVGEAL
LENPKMELHIPQKRRTSMSEGIKQLLKDMLAANPQDRPDAFELETRMDQVTCAA
GenBank ID Protein 260099625
UniProtKB/Swiss-Prot ID Q8TDR2
UniProtKB/Swiss-Prot Entry Name STK35_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_080836.3
GeneCard ID STK35
GenAtlas ID STK35
HGNC ID HGNC:16254
References
General References
  1. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [PubMed:14702039 ]
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  4. Goyal P, Behring A, Kumar A, Siess W: Identifying and characterizing a novel protein kinase STK35L1 and deciphering its orthologs and close-homologs in vertebrates. PLoS One. 2009 Sep 16;4(9):e6981. doi: 10.1371/journal.pone.0006981. [PubMed:19756140 ]
  5. Vallenius T, Makela TP: Clik1: a novel kinase targeted to actin stress fibers by the CLP-36 PDZ-LIM protein. J Cell Sci. 2002 May 15;115(Pt 10):2067-73. [PubMed:11973348 ]