Hmdb loader
Identification
HMDB Protein ID HMDBP01295
Secondary Accession Numbers
  • 6591
Name Calcium/calmodulin-dependent protein kinase type 1G
Synonyms
  1. CLICK III
  2. CaM kinase I gamma
  3. CaM kinase IG
  4. CaM-KI gamma
  5. CaMK-like CREB kinase III
  6. CaMKI gamma
  7. CaMKIG
Gene Name CAMK1G
Protein Type Unknown
Biological Properties
General Function Involved in protein kinase activity
Specific Function Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade. In vitro phosphorylates transcription factor CREB1
Pathways Not Available
Reactions Not Available
GO Classification
Function
binding
catalytic activity
transferase activity
transferase activity, transferring phosphorus-containing groups
kinase activity
nucleoside binding
purine nucleoside binding
adenyl nucleotide binding
adenyl ribonucleotide binding
atp binding
protein kinase activity
protein serine/threonine kinase activity
Process
phosphorus metabolic process
phosphate metabolic process
metabolic process
cellular metabolic process
protein amino acid phosphorylation
phosphorylation
Cellular Location
  1. Cell membrane
  2. Cytoplasm
  3. Golgi apparatus membrane
  4. Peripheral membrane protein
  5. Peripheral membrane protein
Gene Properties
Chromosome Location Chromosome:1
Locus 1q32-q41
SNPs CAMK1G
Gene Sequence
>1431 bp
ATGGGTCGAAAGGAAGAAGATGACTGCAGTTCCTGGAAGAAACAGACCACCAACATCCGG
AAAACCTTCATTTTTATGGAAGTGCTGGGATCAGGAGCTTTCTCAGAAGTTTTCCTGGTG
AAGCAAAGACTGACTGGGAAGCTCTTTGCTCTGAAGTGCATCAAGAAGTCACCTGCCTTC
CGGGACAGCAGCCTGGAGAATGAGATTGCTGTGTTGAAAAAGATCAAGCATGAAAACATT
GTGACCCTGGAGGACATCTATGAGAGCACCACCCACTACTACCTGGTCATGCAGCTTGTT
TCTGGTGGGGAGCTCTTTGACCGGATCCTGGAGCGGGGTGTCTACACAGAGAAGGATGCC
AGTCTGGTGATCCAGCAGGTCTTGTCGGCAGTGAAATACCTACATGAGAATGGCATCGTC
CACAGAGACTTAAAGCCCGAAAACCTGCTTTACCTTACCCCTGAAGAGAACTCTAAGATC
ATGATCACTGACTTTGGTCTGTCCAAGATGGAACAGAATGGCATCATGTCCACTGCCTGT
GGGACCCCAGGCTACGTGGCTCCAGAAGTGCTGGCCCAGAAACCCTACAGCAAGGCTGTG
GATTGCTGGTCCATCGGCGTCATCACCTACATATTGCTCTGTGGATACCCCCCGTTCTAT
GAAGAAACGGAGTCTAAGCTTTTCGAGAAGATCAAGGAGGGCTACTATGAGTTTGAGTCT
CCATTCTGGGATGACATTTCTGAGTCAGCCAAGGACTTTATTTGCCACTTGCTTGAGAAG
GATCCGAACGAGCGGTACACCTGTGAGAAGGCCTTGAGTCATCCCTGGATTGACGGAAAC
ACAGCCCTCCACCGGGACATCTACCCATCAGTCAGCCTCCAGATCCAGAAGAACTTTGCT
AAGAGCAAGTGGAGGCAAGCCTTCAACGCAGCAGCCGTGGTGCACCACATGAGGAAGCTA
CACATGAACCTGCACAGCCCGGGCATCCGCCCAGAGGTGGAGAACAGGCCGCCTGAAACT
CAAGCCTCAGAAACCTCTAGACCCAGCTCCCCTGAGATCACCATCACCGAGGCACCTGTC
CTGGACCACAGTGTAGCACTCCCTGCCCTGACCCAATTACCCTGCCAGCATGGCCGCCGG
CCCACTGCCCCTGGTGGCAGGTCCCTCAACTGCCTGGTCAATGGCTCCCTCCACATCAGC
AGCAGCCTGGTGCCCATGCATCAGGGGTCCCTGGCCGCCGGGCCCTGTGGCTGCTGCTCC
AGCTGCCTGAACATTGGGAACAAAGGAAAGTCCTCCTACTGCTCTGAGCCCACACTCCTC
AAAAAGGCCAACAAAAAACAGAACTTCAAGTCGGAGGTCATGGTACCAGTTAAAGCCAGT
GGCAGCTCCCACTGCCGGGCAGGGCAGACTGGAGTCTGTCTCATTATGTGA
Protein Properties
Number of Residues 476
Molecular Weight 53086.5
Theoretical pI 7.78
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • None
Protein Sequence
>Calcium/calmodulin-dependent protein kinase type 1G
MGRKEEDDCSSWKKQTTNIRKTFIFMEVLGSGAFSEVFLVKQRLTGKLFALKCIKKSPAF
RDSSLENEIAVLKKIKHENIVTLEDIYESTTHYYLVMQLVSGGELFDRILERGVYTEKDA
SLVIQQVLSAVKYLHENGIVHRDLKPENLLYLTPEENSKIMITDFGLSKMEQNGIMSTAC
GTPGYVAPEVLAQKPYSKAVDCWSIGVITYILLCGYPPFYEETESKLFEKIKEGYYEFES
PFWDDISESAKDFICHLLEKDPNERYTCEKALSHPWIDGNTALHRDIYPSVSLQIQKNFA
KSKWRQAFNAAAVVHHMRKLHMNLHSPGVRPEVENRPPETQASETSRPSSPEITITEAPV
LDHSVALPALTQLPCQHGRRPTAPGGRSLNCLVNGSLHISSSLVPMHQGSLAAGPCGCCS
SCLNIGSKGKSSYCSEPTLLKKANKKQNFKSEVMVPVKASGSSHCRAGQTGVCLIM
GenBank ID Protein 16755792
UniProtKB/Swiss-Prot ID Q96NX5
UniProtKB/Swiss-Prot Entry Name KCC1G_HUMAN
PDB IDs Not Available
GenBank Gene ID AF428261
GeneCard ID CAMK1G
GenAtlas ID CAMK1G
HGNC ID HGNC:14585
References
General References
  1. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
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  3. Greenman C, Stephens P, Smith R, Dalgliesh GL, Hunter C, Bignell G, Davies H, Teague J, Butler A, Stevens C, Edkins S, O'Meara S, Vastrik I, Schmidt EE, Avis T, Barthorpe S, Bhamra G, Buck G, Choudhury B, Clements J, Cole J, Dicks E, Forbes S, Gray K, Halliday K, Harrison R, Hills K, Hinton J, Jenkinson A, Jones D, Menzies A, Mironenko T, Perry J, Raine K, Richardson D, Shepherd R, Small A, Tofts C, Varian J, Webb T, West S, Widaa S, Yates A, Cahill DP, Louis DN, Goldstraw P, Nicholson AG, Brasseur F, Looijenga L, Weber BL, Chiew YE, DeFazio A, Greaves MF, Green AR, Campbell P, Birney E, Easton DF, Chenevix-Trench G, Tan MH, Khoo SK, Teh BT, Yuen ST, Leung SY, Wooster R, Futreal PA, Stratton MR: Patterns of somatic mutation in human cancer genomes. Nature. 2007 Mar 8;446(7132):153-8. [PubMed:17344846 ]
  4. Schutte BC, Bjork BC, Coppage KB, Malik MI, Gregory SG, Scott DJ, Brentzell LM, Watanabe Y, Dixon MJ, Murray JC: A preliminary gene map for the Van der Woude syndrome critical region derived from 900 kb of genomic sequence at 1q32-q41. Genome Res. 2000 Jan;10(1):81-94. [PubMed:10645953 ]
  5. Takemoto-Kimura S, Terai H, Takamoto M, Ohmae S, Kikumura S, Segi E, Arakawa Y, Furuyashiki T, Narumiya S, Bito H: Molecular cloning and characterization of CLICK-III/CaMKIgamma, a novel membrane-anchored neuronal Ca2+/calmodulin-dependent protein kinase (CaMK). J Biol Chem. 2003 May 16;278(20):18597-605. Epub 2003 Mar 11. [PubMed:12637513 ]