Hmdb loader
Identification
HMDB Protein ID HMDBP01297
Secondary Accession Numbers
  • 6593
Name Testis-specific serine/threonine-protein kinase 2
Synonyms
  1. DiGeorge syndrome protein G
  2. Serine/threonine-protein kinase 22B
  3. TSK-2
  4. TSSK-2
  5. Testis-specific kinase 2
Gene Name TSSK2
Protein Type Unknown
Biological Properties
General Function Involved in protein kinase activity
Specific Function Involved in the late stages of spermatogenesis, during the reconstruction of the cytoplasm
Pathways Not Available
Reactions Not Available
GO Classification
Function
ion binding
cation binding
metal ion binding
binding
catalytic activity
transferase activity
transferase activity, transferring phosphorus-containing groups
kinase activity
nucleoside binding
purine nucleoside binding
adenyl nucleotide binding
adenyl ribonucleotide binding
atp binding
magnesium ion binding
protein kinase activity
protein serine/threonine kinase activity
Process
phosphorus metabolic process
phosphate metabolic process
metabolic process
cellular process
cellular metabolic process
cellular developmental process
cell differentiation
protein amino acid phosphorylation
phosphorylation
Cellular Location
  1. Cytoplasm
Gene Properties
Chromosome Location Chromosome:2
Locus 22q11.21
SNPs TSSK2
Gene Sequence
>1077 bp
ATGGACGATGCCACAGTCCTAAGGAAGAAGGGTTACATCGTAGGCATCAATCTTGGCAAG
GGTTCCTACGCAAAAGTCAAATCTGCCTACTCTGAGCGCCTCAAGTTCAATGTGGCTGTC
AAGATCATCGACCGCAAGAAAACACCTACTGACTTTGTGGAGAGATTCCTTCCTCGGGAG
ATGGACATCCTGGCAACTGTCAACCACGGCTCCATCATCAAGACTTACGAGATCTTTGAG
ACCTCTGACGGACGGATCTACATCATCATGGAGCTTGGCGTCCAGGGCGACCTCCTCGAG
TTCATCAAGTGCCAGGGAGCCCTGCATGAGGACGTGGCACGCAAGATGTTCCGACAGCTC
TCCTCCGCCGTCAAGTACTGCCACGACCTGGACATCGTCCACCGGGACCTCAAGTGCGAG
AACCTTCTCCTCGACAAGGACTTCAACATCAAGCTGTCTGACTTTGGCTTCTCCAAGCGC
TGCCTGCGGGACAGCAATGGGCGCATCATCCTCAGCAAGACCTTCTGCGGGTCGGCAGCA
TATGCAGCCCCCGAGGTGCTGCAGAGCATCCCCTACCAGCCCAAGGTGTATGACATCTGG
AGCCTGGGCGTGATCCTGTACATCATGGTCTGCGGCTCCATGCCCTATGACGACTCCGAC
ATCAGGAAGATGCTGCGTATCCAGAAGGAGCACCGTGTGGACTTCCCGCGCTCCAAGAAC
CTGACCTGCGAGTGCAAGGACCTCATCTACCGCATGCTGCAGCCCGACGTCAGCCAGCGG
CTCCACATCGATGAGATCCTCAGCCACTCGTGGCTGCAGCCCCCCAAGCCCAAGCCAACG
TCTTCTGCTTCCTTCAAGAGGGAGGGGGAGGGCAAGTACCGCGCTGAGTGCAAACTGGAC
ACCAAGACAGGCTTGAGGCCCGACCACCGGCCCGACCACAAGCTTGGAGCCAAAACCCAG
CACCGGCTGCTGGTGGTGCCCGAGAACGAGAACAGGATGGAGGACAGGCTGGCCGAGACC
TCCAGGGCCAAAGACCATCACATCTCCGGAGCTGAGGTGGGGAAAGCAAGCACCTAG
Protein Properties
Number of Residues 358
Molecular Weight 40938.8
Theoretical pI 9.13
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • None
Protein Sequence
>Testis-specific serine/threonine-protein kinase 2
MDDATVLRKKGYIVGINLGKGSYAKVKSAYSERLKFNVAVKIIDRKKTPTDFVERFLPRE
MDILATVNHGSIIKTYEIFETSDGRIYIIMELGVQGDLLEFIKCQGALHEDVARKMFRQL
SSAVKYCHDLDIVHRDLKCENLLLDKDFNIKLSDFGFSKRCLRDSNGRIILSKTFCGSAA
YAAPEVLQSIPYQPKVYDIWSLGVILYIMVCGSMPYDDSDIRKMLRIQKEHRVDFPRSKN
LTCECKDLIYRMLQPDVSQRLHIDEILSHSWLQPPKPKATSSASFKREGEGKYRAECKLD
TKTGLRPDHRPDHKLGAKTQHRLLVVPENENRMEDRLAETSRAKDHHISGAEVGKAST
GenBank ID Protein 15430703
UniProtKB/Swiss-Prot ID Q96PF2
UniProtKB/Swiss-Prot Entry Name TSSK2_HUMAN
PDB IDs Not Available
GenBank Gene ID AF362953
GeneCard ID TSSK2
GenAtlas ID TSSK2
HGNC ID HGNC:11401
References
General References
  1. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  2. Collins JE, Wright CL, Edwards CA, Davis MP, Grinham JA, Cole CG, Goward ME, Aguado B, Mallya M, Mokrab Y, Huckle EJ, Beare DM, Dunham I: A genome annotation-driven approach to cloning the human ORFeome. Genome Biol. 2004;5(10):R84. Epub 2004 Sep 30. [PubMed:15461802 ]
  3. Greenman C, Stephens P, Smith R, Dalgliesh GL, Hunter C, Bignell G, Davies H, Teague J, Butler A, Stevens C, Edkins S, O'Meara S, Vastrik I, Schmidt EE, Avis T, Barthorpe S, Bhamra G, Buck G, Choudhury B, Clements J, Cole J, Dicks E, Forbes S, Gray K, Halliday K, Harrison R, Hills K, Hinton J, Jenkinson A, Jones D, Menzies A, Mironenko T, Perry J, Raine K, Richardson D, Shepherd R, Small A, Tofts C, Varian J, Webb T, West S, Widaa S, Yates A, Cahill DP, Louis DN, Goldstraw P, Nicholson AG, Brasseur F, Looijenga L, Weber BL, Chiew YE, DeFazio A, Greaves MF, Green AR, Campbell P, Birney E, Easton DF, Chenevix-Trench G, Tan MH, Khoo SK, Teh BT, Yuen ST, Leung SY, Wooster R, Futreal PA, Stratton MR: Patterns of somatic mutation in human cancer genomes. Nature. 2007 Mar 8;446(7132):153-8. [PubMed:17344846 ]
  4. Gong W, Emanuel BS, Collins J, Kim DH, Wang Z, Chen F, Zhang G, Roe B, Budarf ML: A transcription map of the DiGeorge and velo-cardio-facial syndrome minimal critical region on 22q11. Hum Mol Genet. 1996 Jun;5(6):789-800. [PubMed:8776594 ]