Survey with prize
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Identification
HMDB Protein ID HMDBP01345
Secondary Accession Numbers
  • 6641
Name Ephrin type-A receptor 1
Synonyms
  1. Tyrosine-protein kinase receptor EPH
Gene Name EPHA1
Protein Type Enzyme
Biological Properties
General Function Involved in ephrin receptor activity
Specific Function Receptor for members of the ephrin-A family. Binds with a low affinity to ephrin-A1
Pathways Not Available
Reactions Not Available
GO Classification
Component
integral to plasma membrane
membrane
cell part
membrane part
intrinsic to membrane
integral to membrane
Function
protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase activity
binding
catalytic activity
transferase activity
transferase activity, transferring phosphorus-containing groups
kinase activity
nucleoside binding
purine nucleoside binding
adenyl nucleotide binding
adenyl ribonucleotide binding
atp binding
ephrin receptor activity
protein binding
protein kinase activity
Process
phosphorus metabolic process
phosphate metabolic process
enzyme linked receptor protein signaling pathway
transmembrane receptor protein tyrosine kinase signaling pathway
metabolic process
ephrin receptor signaling pathway
cellular metabolic process
protein amino acid phosphorylation
signaling
signaling pathway
cell surface receptor linked signaling pathway
phosphorylation
Cellular Location
  1. Membrane
  2. Single-pass type I membrane protein
Gene Properties
Chromosome Location Chromosome:7
Locus 7q34
SNPs EPHA1
Gene Sequence
>2931 bp
ATGGAGCGGCGCTGGCCCCTGGGGCTAGGGCTGGTGCTGCTGCTCTGCGCCCCGCTGCCC
CCGGGGGCGCGCGCCAAGGAAGTTACTCTGATGGACACAAGCAAGGCACAGGGAGAGCTG
GGCTGGCTGCTGGATCCCCCAAAAGATGGGTGGAGTGAACAGCAACAGATACTGAATGGG
ACACCCCTGTACATGTACCAGGACTGCCCAATGCAAGGACGCAGAGACACTGACCACTGG
CTTCGCTCCAATTGGATCTACCGCGGGGAGGAGGCTTCCCGCGTCCACGTGGAGCTGCAG
TTCACCGTGCGGGACTGCAAGAGTTTCCCTGGGGGAGCCGGGCCTCTGGGCTGCAAGGAG
ACCTTCAACCTTCTGTACATGGAGAGTGACCAGGATGTGGGCATTCAGCTCCGACGGCCC
TTGTTCCAGAAGGTAACCACGGTGGCTGCAGACCAGAGCTTCACCATTCGAGACCTTGCG
TCTGGCTCCGTGAAGCTGAATGTGGAGCGCTGCTCTCTGGGCCGCCTGACCCGCCGTGGC
CTCTACCTCGCTTTCCACAACCCGGGTGCCTGTGTGGCCCTGGTGTCTGTCCGGGTCTTC
TACCAGCGCTGTCCTGAGACCCTGAATGGCTTGGCCCAATTCCCAGACACTCTGCCTGGC
CCCGCTGGGTTGGTGGAAGTGGCGGGGACCTGCTTGCCCCACGCGCGGGCCAGCCCCAGG
CCCTCAGGTGCACCCCGCATGCACTGCAGCCCTGATGGCGAGTGGCTGGTGCCTGTAGGA
CGGTGCCACTGTGAGCCTGGCTATGAGGAAGGTGGCAGTGGCGAAGCATGTGTTGCCTGC
CCTAGCGGCTCCTACCGGATGGACATGGACACACCCCATTGTCTCACGTGCCCCCAGCAG
AGCACTGCTGAGTCTGAGGGGGCCACCATCTGTACCTGTGAGAGCGGCCATTACAGAGCT
CCCGGGGAGGGCCCCCAGGTGGCATGCACAGGTCCCCCCTCGGCCCCCCGAAACCTGAGC
TTCTCTGCCTCAGGGACTCAGCTCTCCCTGCGTTGGGAACCCCCAGCAGATACGGGGGGA
CGCCAGGATGTCAGATACAGTGTGAGGTGTTCCCAGTGTCAGGGCACAGCACAGGACGGG
GGGCCCTGCCAGCCCTGTGGGGTGGGCGTGCACTTCTCGCCGGGGGCCCGGGGGCTCACC
ACACCTGCAGTGCATGTCAATGGCCTTGAACCTTATGCCAACTACACCTTTAATGTGGAA
GCCCAAAATGGAGTGTCAGGGCTGGGCAGCTCTGGCCATGCCAGCACCTCAGTCAGCATC
AGCATGGGGCATGCAGAGTCACTGTCAGGCCTGTCTCTGAGACTGGTGAAGAAAGAACCG
AGGCAACTAGAGCTGACCTGGGCGGGGTCCCGGCCCCGAAGCCCTGGGGCGAACCTGACC
TATGAGCTGCACGTGCTGAACCAGGATGAAGAACGGTACCAGATGGTTCTAGAACCCAGG
GTCTTGCTGACAGAGCTGCAGCCTGACACCACATACATCGTCAGAGTCCGAATGCTGACC
CCACTGGGTCCTGGCCCTTTCTCCCCTGATCATGAGTTTCGGACCAGCCCACCAGTGTCC
AGGGGCCTGACTGGAGGAGAGATTGTAGCCGTCATCTTTGGGCTGCTGCTTGGTGCAGCC
TTGCTGCTTGGGATTCTCGTTTTCCGGTCCAGGAGAGCCCAGCGGCAGAGGCAGCAGAGG
CAGCGTGACCGCGCCACCGATGTGGATCGAGAGGACAAGCTGTGGCTGAAGCCTTATGTG
GACCTCCAGGCATACGAGGACCCTGCACAGGGAGCCTTGGACTTTACCCGGGAGCTTGAT
CCAGCGTGGCTGATGGTGGACACTGTCATAGGAGAAGGAGAGTTTGGGGAAGTGTATCGA
GGGACCCTGAGGCTCCCCAGCCAGGACTGCAAGACTGTGGCCATTAAGACCTTAAAAGAC
ACATCCCCAGGTGGCCAGTGGTGGAACTTCCTTCGAGAGGCAACTATCATGGGCCAGTTT
AGCCACCCGCATATTCTGCATCTGGAAGGCGTCGTCACAAAGCGAAAGCCGATCATGATC
ATCACAGAATTTATGGAGAATGGAGCCCTGGATGCCTTCCTGAGGGAGCGGGAGGACCAG
CTGGTCCCTGGGCAGCTAGTGGCCATGCTGCAGGGCATAGCATCTGGCATGAACTACCTC
AGTAATCACAATTATGTCCACCGGGACCTGGCTGCCAGAAACATCTTGGTGAATCAAAAC
CTGTGCTGCAAGGTGTCTGACTTTGGCCTGACTCGCCTCCTGGATGACTTTGATGGCACA
TACGAAACCCAGGGAGGAAAGATCCCTATCCGTTGGACAGCCCCTGAAGCCATTGCCCAT
CGGATCTTCACCACAGCCAGCGATGTGTGGAGCTTTGGGATTGTGATGTGGGAGGTGCTG
AGCTTTGGGGACAAGCCTTATGGGGAGATGAGCAATCAGGAGGTTATGAAGAGCATTGAG
GATGGGTACCGGTTGCCCCCTCCTGTGGACTGCCCTGCCCCTCTGTATGAGCTCATGAAG
AACTGCTGGGCATATGACCGTGCCCGCCGGCCACACTTCCAGAAGCTTCAGGCACATCTG
GAGCAACTGCTTGCCAACCCCCACTCCCTGCGGACCATTGCCAACTTTGACCCCAGGGTG
ACTCTTCGCCTGCCCAGCCTGAGTGGCTCAGATGGGATCCCGTATCGAACCGTCTCTGAG
TGGCTCGAGTCCATACGCATGAAACGCTACATCCTGCACTTCCACTCGGCTGGGCTGGAC
ACCATGGAGTGTGTGCTGGAGCTGACCGCTGAGGACCTGACGCAGATGGGAATCACACTG
CCCGGGCACCAGAAGCGCATTCTTTGCAGTATTCAGGGATTCAAGGACTGA
Protein Properties
Number of Residues 976
Molecular Weight 108066.2
Theoretical pI 6.63
Pfam Domain Function
Signals
  • 1-23
Transmembrane Regions
  • 548-568
Protein Sequence
>Ephrin type-A receptor 1
MERRWPLGLGLVLLLCAPLPPGARAKEVTLMDTSKAQGELGWLLDPPKDGWSEQQQILNG
TPLYMYQDCPMQGRRDTDHWLRSNWIYRGEEASRVHVELQFTVRDCKSFPGGAGPLGCKE
TFNLLYMESDQDVGIQLRRPLFQKVTTVAADQSFTIRDLASGSVKLNVERCSLGRLTRRG
LYLAFHNPGACVALVSVRVFYQRCPETLNGLAQFPDTLPGPAGLVEVAGTCLPHARASPR
PSGAPRMHCSPDGEWLVPVGRCHCEPGYEEGGSGEACVACPSGSYRMDMDTPHCLTCPQQ
STAESEGATICTCESGHYRAPGEGPQVACTGPPSAPRNLSFSASGTQLSLRWEPPADTGG
RQDVRYSVRCSQCQGTAQDGGPCQPCGVGVHFSPGARGLTTPAVHVNGLEPYANYTFNVE
AQNGVSGLGSSGHASTSVSISMGHAESLSGLSLRLVKKEPRQLELTWAGSRPRSPGANLT
YELHVLNQDEERYQMVLEPRVLLTELQPDTTYIVRVRMLTPLGPGPFSPDHEFRTSPPVS
RGLTGGEIVAVIFGLLLGAALLLGILVFRSRRAQRQRQQRQRDRATDVDREDKLWLKPYV
DLQAYEDPAQGALDFTRELDPAWLMVDTVIGEGEFGEVYRGTLRLPSQDCKTVAIKTLKD
TSPGGQWWNFLREATIMGQFSHPHILHLEGVVTKRKPIMIITEFMENGALDAFLREREDQ
LVPGQLVAMLQGIASGMNYLSNHNYVHRDLAARNILVNQNLCCKVSDFGLTRLLDDFDGT
YETQGGKIPIRWTAPEAIAHRIFTTASDVWSFGIVMWEVLSFGDKPYGEMSNQEVMKSIE
DGYRLPPPVDCPAPLYELMKNCWAYDRARRPHFQKLQAHLEQLLANPHSLRTIANFDPRV
TLRLPSLSGSDGIPYRTVSEWLESIRMKRYILHFHSAGLDTMECVLELTAEDLTQMGITL
PGHQKRILCSIQGFKD
GenBank ID Protein 120660150
UniProtKB/Swiss-Prot ID P21709
UniProtKB/Swiss-Prot Entry Name EPHA1_HUMAN
PDB IDs Not Available
GenBank Gene ID BC130291
GeneCard ID EPHA1
GenAtlas ID EPHA1
HGNC ID HGNC:3385
References
General References
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