Hmdb loader
Identification
HMDB Protein ID HMDBP01437
Secondary Accession Numbers
  • 6733
Name Serine/threonine-protein kinase 25
Synonyms
  1. SOK-1
  2. Ste20-like kinase
  3. Ste20/oxidant stress response kinase 1
  4. Sterile 20/oxidant stress-response kinase 1
Gene Name STK25
Protein Type Unknown
Biological Properties
General Function Involved in protein kinase activity
Specific Function Oxidant stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Targets to the Golgi apparatus where it appears to regulate protein transport events, cell adhesion, and polarity complexes important for cell migration
Pathways Not Available
Reactions Not Available
GO Classification
Function
binding
catalytic activity
transferase activity
transferase activity, transferring phosphorus-containing groups
kinase activity
nucleoside binding
purine nucleoside binding
adenyl nucleotide binding
adenyl ribonucleotide binding
atp binding
protein kinase activity
protein serine/threonine kinase activity
Process
phosphorus metabolic process
phosphate metabolic process
metabolic process
cellular metabolic process
protein amino acid phosphorylation
phosphorylation
Cellular Location
  1. Cytoplasm
  2. Golgi apparatus
Gene Properties
Chromosome Location Chromosome:2
Locus 2q37.3
SNPs STK25
Gene Sequence
>1281 bp
ATGGCTCACCTCCGGGGATTTGCCAACCAGCACTCTCGAGTGGACCCTGAGGAGCTCTTC
ACCAAGCTCGACCGCATTGGCAAGGGCTCGTTTGGGGAGGTCTACAAGGGCATCGATAAC
CACACAAAGGAGGTGGTGGCCATCAAGATCATCGACCTGGAGGAGGCCGAGGATGAGATC
GAGGACATCCAGCAGGAGATCACTGTCCTCAGTCAGTGCGACAGCCCCTACATCACCCGC
TACTTTGGCTCCTACCTAAAGAGCACCAAGCTATGGATCATCATGGAGTACCTGGGCGGC
GGCTCAGCACTGGACTTGCTTAAACCAGGTCCCCTGGAGGAGACATACATTGCCACGATC
CTGCGGGAGATTCTGAAGGGCCTGGATTATCTGCACTCCGAACGCAAGATCCACCGAGAC
ATCAAAGCTGCCAACGTGCTACTCTCGGAGCAGGGTGACGTGAAGCTGGCGGACTTTGGG
GTAGCAGGGCAGCTCACAGACACGCAGATTAAGAGGAACACATTCGTGGGCACCCCCTTC
TGGATGGCACCTGAGGTCATCAAGCAGTCGGCCTACGACTTCAAGGCTGACATCTGGTCC
CTGGGGATCACAGCCATCGAGCTGGCCAAGGGGGAGCCTCCAAACTCTGACCTCCACCCC
ATGCGCGTCCTGTTCCTGATTCCCAAGAACAGCCCACCCACACTGGAGGGCCAGCACAGC
AAGCCCTTCAAGGAGTTCGTGGAGGCCTGCCTCAACAAAGACCCCCGATTCCGGCCCACG
GCCAAGGAGCTCCTGAAGCACAAGTTCATCACACGCTACACCAAGAAGACCTCCTTCCTC
ACGGAGCTCATCGACCGCTATAAGCGCTGGAAGTCAGAGGGGCATGGCGAGGAGTCCAGC
TCTGAGGACTCTGACATTGATGGCGAGGCGGAGGACGGGGAGCAGGGCCCCATCTGGACG
TTCCCCCCTACCATCCGGCCGAGTCCACACAGCAAGCTTCACAAGGGGACGGCCCTGCAC
AGTTCACAGAAGCCTGCGGAGCCCGTCAAGAGGCAGCCGAGGTCCCAGTGCCTGTCCACG
CTGGTCCGGCCCGTCTTCGGAGAGCTCAAAGAGAAGCACAAGCAGAGCGGCGGGAGCGTG
GGTGCGCTGGAGGAGCTGGAGAACGCCTTCAGCCTGGCCGAGGAGTCCTGCCCCGGCATC
TCAGACAAGCTGATGGTGCACCTGGTGGAGCGAGTGCAGAGGTTTTCACACAACAGAAAC
CACCTGACATCCACCCGCTGA
Protein Properties
Number of Residues 426
Molecular Weight 48111.3
Theoretical pI 6.73
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • None
Protein Sequence
>Serine/threonine-protein kinase 25
MAHLRGFANQHSRVDPEELFTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEI
EDIQQEITVLSQCDSPYITRYFGSYLKSTKLWIIMEYLGGGSALDLLKPGPLEETYIATI
LREILKGLDYLHSERKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPF
WMAPEVIKQSAYDFKADIWSLGITAIELAKGEPPNSDLHPMRVLFLIPKNSPPTLEGQHS
KPFKEFVEACLNKDPRFRPTAKELLKHKFITRYTKKTSFLTELIDRYKRWKSEGHGEESS
SEDSDIDGEAEDGEQGPIWTFPPTIRPSPHSKLHKGTALHSSQKPAEPVKRQPRSQCLST
LVRPVFGELKEKHKQSGGSVGALEELENAFSLAEESCPGISDKLMVHLVERVQRFSHNRN
HLTSTR
GenBank ID Protein 62822134
UniProtKB/Swiss-Prot ID O00506
UniProtKB/Swiss-Prot Entry Name STK25_HUMAN
PDB IDs Not Available
GenBank Gene ID AC110299
GeneCard ID STK25
GenAtlas ID STK25
HGNC ID HGNC:11404
References
General References
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  7. Pombo CM, Bonventre JV, Molnar A, Kyriakis J, Force T: Activation of a human Ste20-like kinase by oxidant stress defines a novel stress response pathway. EMBO J. 1996 Sep 2;15(17):4537-46. [PubMed:8887545 ]
  8. Osada S, Izawa M, Saito R, Mizuno K, Suzuki A, Hirai S, Ohno S: YSK1, a novel mammalian protein kinase structurally related to Ste20 and SPS1, but is not involved in the known MAPK pathways. Oncogene. 1997 May 1;14(17):2047-57. [PubMed:9160885 ]
  9. Preisinger C, Short B, De Corte V, Bruyneel E, Haas A, Kopajtich R, Gettemans J, Barr FA: YSK1 is activated by the Golgi matrix protein GM130 and plays a role in cell migration through its substrate 14-3-3zeta. J Cell Biol. 2004 Mar 29;164(7):1009-20. Epub 2004 Mar 22. [PubMed:15037601 ]