Hmdb loader
Identification
HMDB Protein ID HMDBP01440
Secondary Accession Numbers
  • 6736
Name Cyclin-dependent kinase-like 1
Synonyms
  1. Protein kinase p42 KKIALRE
  2. Serine/threonine-protein kinase KKIALRE
Gene Name CDKL1
Protein Type Enzyme
Biological Properties
General Function Involved in protein kinase activity
Specific Function ATP + a protein = ADP + a phosphoprotein
Pathways Not Available
Reactions Not Available
GO Classification
Function
binding
catalytic activity
transferase activity
transferase activity, transferring phosphorus-containing groups
kinase activity
nucleoside binding
purine nucleoside binding
adenyl nucleotide binding
adenyl ribonucleotide binding
atp binding
protein kinase activity
protein serine/threonine kinase activity
Process
phosphorus metabolic process
phosphate metabolic process
metabolic process
cellular metabolic process
protein amino acid phosphorylation
phosphorylation
Cellular Location
  1. Nucleus
  2. Cytoplasm
Gene Properties
Chromosome Location Chromosome:1
Locus 14q21.3
SNPs CDKL1
Gene Sequence
>1077 bp
ATGATGGAGAAGTATGAAAAAATTGGGAAAATTGGAGAAGGATCCTATGGAGTTGTTTTC
AAATGTAGAAACAGGGACACGGGTCAGATTGTGGCCATCAAGAAGTTTCTGGAATCAGAA
GATGACCCTGTCATAAAGAAAATTGCCCTTCGGGAAATCCGAATGCTCAAGCAACTCAAG
CATCCCAACCTTGTTAACCTCCTGGAAGTCTTCAGGAGGAAACGGAGGCTTCACCTGGTG
TTTGAATATTGTGACCACACAGTTCTCCATGAGTTGGACAGATACCAAAGAGGGGTACCA
GAACATCTCGTGAAGAGCATAACTTGGCAGACACTGCAAGCTGTAAATTTTTGCCATAAA
CACAATTGCATACATAGAGACGTGAAGCCAGAAAATATCCTCATCACGAAACATTCCGTG
ATTAAGCTTTGTGACTTTGGATTTGCTCGGCTTTTGACTGGACCGAGTGACTACTATACA
GACTACGTGGCTACCAGGTGGTACCGCTCCCCTGAGCTGCTGGTGGGGGACACGCAGTAC
GGCCCCCCGGTGGATGTTTGGGCAATTGGCTGTGTCTTTGCTGAGCTGCTGTCAGGAGTG
CCTCTGTGGCCAGGAAAATCGGATGTGGATCAGCTGTATCTGATTAGGAAGACCTTGGGG
GATCTCATTCCTAGGCACCAGCAAGTGTTTAGCACGAATCAGTACTTCAGTGGAGTGAAA
ATTCCAGACCCTGAAGATATGGAACCACTTGAATTAAAATTCCCAAACATCTCTTATCCT
GCCCTGGGGCTCCTAAAGGGCTGTCTCCACATGGACCCTACTCAAAGGCTGACATGTGAA
CAGCTGTTGCATCACCCATATTTTGAAAACATCAGAGAAATAGAGGATTTGGCAAAAGAA
CACAACAAACCAACAAGGAAGACCCTAAGAAAGAGCCGAAAGCACCACTGCTTTACAGAA
ACATCCAAGTTGCAGTACCTACCCCAGCTAACTGGCAGCAGCATCCTTCCAGCTTTGGAT
AATAAGAAGTACTACTGTGATACCAAGAAACTTAACTACCGTTTTCCAAACATTTAA
Protein Properties
Number of Residues 357
Molecular Weight 41671.0
Theoretical pI 9.11
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • None
Protein Sequence
>Cyclin-dependent kinase-like 1
MEKYEKIGKIGEGSYGVVFKCRNRDTGQIVAIKKFLESEDDPVIKKIALREIRMLKQLKH
PNLVNLLEVFRRKRRLHLVFEYCDHTVLHELDRYQRGVPEHLVKSITWQTLQAVNFCHKH
NCIHRDVKPENILITKHSVIKLCDFGFARLLAGPSDYYTDYVATRWYRSPELLVGDTQYG
PPVDVWAIGCVFAELLSGVPLWPGKSDVDQLYLIRKTLGDLIPRHQQVFSTNQYFSGVKI
PDPEDMEPLELKFPNISYPALGLLKGCLHMDPTQRLTCEQLLHHPYFENIREIEDLAKEH
NKPTRKTLRKSRKHHCFTETSKLQYLPQLTGSSILPALDNKKYYCDTKKLNYRFPNI
GenBank ID Protein 37596297
UniProtKB/Swiss-Prot ID Q00532
UniProtKB/Swiss-Prot Entry Name CDKL1_HUMAN
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID CDKL1
GenAtlas ID CDKL1
HGNC ID HGNC:1781
References
General References
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  2. Heilig R, Eckenberg R, Petit JL, Fonknechten N, Da Silva C, Cattolico L, Levy M, Barbe V, de Berardinis V, Ureta-Vidal A, Pelletier E, Vico V, Anthouard V, Rowen L, Madan A, Qin S, Sun H, Du H, Pepin K, Artiguenave F, Robert C, Cruaud C, Bruls T, Jaillon O, Friedlander L, Samson G, Brottier P, Cure S, Segurens B, Aniere F, Samain S, Crespeau H, Abbasi N, Aiach N, Boscus D, Dickhoff R, Dors M, Dubois I, Friedman C, Gouyvenoux M, James R, Madan A, Mairey-Estrada B, Mangenot S, Martins N, Menard M, Oztas S, Ratcliffe A, Shaffer T, Trask B, Vacherie B, Bellemere C, Belser C, Besnard-Gonnet M, Bartol-Mavel D, Boutard M, Briez-Silla S, Combette S, Dufosse-Laurent V, Ferron C, Lechaplais C, Louesse C, Muselet D, Magdelenat G, Pateau E, Petit E, Sirvain-Trukniewicz P, Trybou A, Vega-Czarny N, Bataille E, Bluet E, Bordelais I, Dubois M, Dumont C, Guerin T, Haffray S, Hammadi R, Muanga J, Pellouin V, Robert D, Wunderle E, Gauguet G, Roy A, Sainte-Marthe L, Verdier J, Verdier-Discala C, Hillier L, Fulton L, McPherson J, Matsuda F, Wilson R, Scarpelli C, Gyapay G, Wincker P, Saurin W, Quetier F, Waterston R, Hood L, Weissenbach J: The DNA sequence and analysis of human chromosome 14. Nature. 2003 Feb 6;421(6923):601-7. Epub 2003 Jan 1. [PubMed:12508121 ]
  3. Greenman C, Stephens P, Smith R, Dalgliesh GL, Hunter C, Bignell G, Davies H, Teague J, Butler A, Stevens C, Edkins S, O'Meara S, Vastrik I, Schmidt EE, Avis T, Barthorpe S, Bhamra G, Buck G, Choudhury B, Clements J, Cole J, Dicks E, Forbes S, Gray K, Halliday K, Harrison R, Hills K, Hinton J, Jenkinson A, Jones D, Menzies A, Mironenko T, Perry J, Raine K, Richardson D, Shepherd R, Small A, Tofts C, Varian J, Webb T, West S, Widaa S, Yates A, Cahill DP, Louis DN, Goldstraw P, Nicholson AG, Brasseur F, Looijenga L, Weber BL, Chiew YE, DeFazio A, Greaves MF, Green AR, Campbell P, Birney E, Easton DF, Chenevix-Trench G, Tan MH, Khoo SK, Teh BT, Yuen ST, Leung SY, Wooster R, Futreal PA, Stratton MR: Patterns of somatic mutation in human cancer genomes. Nature. 2007 Mar 8;446(7132):153-8. [PubMed:17344846 ]
  4. Meyerson M, Enders GH, Wu CL, Su LK, Gorka C, Nelson C, Harlow E, Tsai LH: A family of human cdc2-related protein kinases. EMBO J. 1992 Aug;11(8):2909-17. [PubMed:1639063 ]
  5. Taglienti CA, Wysk M, Davis RJ: Molecular cloning of the epidermal growth factor-stimulated protein kinase p56 KKIAMRE. Oncogene. 1996 Dec 19;13(12):2563-74. [PubMed:9000130 ]