Hmdb loader
Identification
HMDB Protein ID HMDBP01468
Secondary Accession Numbers
  • 6764
Name Serine/threonine-protein kinase tousled-like 1
Synonyms
  1. PKU-beta
  2. Tousled-like kinase 1
Gene Name TLK1
Protein Type Unknown
Biological Properties
General Function Involved in protein kinase activity
Specific Function Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S- phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. Isoform 3 phosphorylates and enhances the stability of the t-SNARE SNAP23, augmenting its assembly with syntaxin. Isoform 3 protects the cells from the ionizing radiation by faciliting the repair of DSBs. In vitro, phosphorylates histone H3 at 'Ser-10'
Pathways Not Available
Reactions Not Available
GO Classification
Function
binding
catalytic activity
transferase activity
transferase activity, transferring phosphorus-containing groups
kinase activity
nucleoside binding
purine nucleoside binding
adenyl nucleotide binding
adenyl ribonucleotide binding
atp binding
protein kinase activity
protein serine/threonine kinase activity
Process
phosphorus metabolic process
phosphate metabolic process
metabolic process
cellular metabolic process
protein amino acid phosphorylation
phosphorylation
Cellular Location
  1. Nucleus
Gene Properties
Chromosome Location Chromosome:2
Locus 2q31.1
SNPs TLK1
Gene Sequence
>2301 bp
ATGAGTGTCCAAAGTAGCAGTGGAAGTTTGGAGGGGCCGCCATCTTGGTCCCAGCTCTCC
ACGTCTCCAACCCCGGGCTCGGCGGCGGCGGCCAGGTCCCTGCTGAATCACACGCCGCCA
TCCGGGAGGCCCAGGGAAGGTGCAATGGATGAGCTTCATAGTCTGGATCCAAGAAGGCAA
GAGTTATTGGAAGCTAGATTTACTGGAGTTGCAAGTGGGAGCACTGGAAGTACGGGCAGT
TGCAGTGTTGGAGCTAAAGCCTCAACAAATAACGAAAGCTCTAATCACAGTTTTGGAAGC
TTGGGATCTTTAAGTGACAAAGAATCAGAGACACCGGAGAAGAAACAATCGGAATCATCC
AGGGGAAGAAAGAGAAAAGCAGAAAACCAGAATGAAAGTAGTCAGGGAAAAAGTATTGGG
GGACGTGGCCACAAAATTAGCGACTATTTTGAATACCAGGGTGGAAATGGCTCAAGTCCA
GTAAGAGGCATACCTCCTGCAATCCGTTCTCCTCAAAATTCACATTCACATTCCACTCCT
TCCTCATCTGTTCGACCGAATAGCCCTTCTCCTACTGCATTAGCATTTGGGGACCACCCT
ATTGTACAACCAAAGCAATTATCCTTTAAAATTATTCAGACTGATCTCACAATGCTGAAA
TTAGCAGCATTAGAAAGTAATAAAATCCAGGACCTGGAAAAGAAGGAGGGACGTATAGAT
GATTTGCTCAGGGCTAACTGTGATCTCAGACGGCAAATAGATGAACAACAAAAATTACTT
GAAAAATACAAAGAACGATTAAATAAGTGCATATCAATGAGCAAGAAACTTCTTATTGAA
AAGAGTACACAAGAAAAGCTGTCAAGCAGAGAGAAGAGTATGCAAGATCGATTACGCCTC
GGGCACTTTACAACAGTTAGACATGGCGCTTCATTTACTGAACAATGGACAGATGGTTTT
GCATTTCAGAATCTTGTGAAGCAACAAGAATGGGTGAATCAGCAAAGGGAAGATATTGAA
AGGCAAAGGAAACTTCTAGCCAAACGCAAACCTCCCACAGCTAATAATTCTCAGGCACCC
TCTACCAATTCTGAACCAAAACAAAGGAAAAACAAAGCAGTCAATGGAGCAGAGAATGAT
CCCTTTGTTAGACCAAATTTACCACAACTGTTGACTTTGGCAGAATATCATGAACAGGAA
GAAATTTTCAAACTTAGACTAGGACATCTCAAAAAGGAAGAGGCAGAAATCCAGGCAGAA
CTTGAACGTTTGGAAAGAGTCAGAAATCTTCACATACGTGAGCTGAAAAGAATAAACAAT
GAAGATAATTCACAGTTCAAAGATCACCCAACATTAAATGAAAGATATTTATTACTTCAT
CTGCTTGGTAGAGGTGGCTTTAGTGAAGTGTATAAGGCTTTTGACCTTTATGAACAAAGA
TATGCTGCTGTGAAGATACATCAGCTTAATAAAAGCTGGAGAGATGAGAAGAAAGAAAAC
TACCACAAACATGCCTGCAGAGAGTATAGAATACACAAAGAACTGGATCACCCCAGAATA
GTTAAACTCTATGATTATTTCTCCTTGGATACAGATACGTTTTGTACAGTGTTAGAATAC
TGTGAAGGCAATGACTTGGATTTCTATCTGAAGCAACACAAGTTAATGTCAGAGAAAGAA
GCTCGGTCTATTGTAATGCAGATTGTAAATGCACTAAGATATCTCAATGAGATCAAACCC
CCTATTATACATTATGATCTTAAGCCAGGAAACATCCTACTGGTAGATGGAACAGCATGT
GGTGAAATCAAAATCACTGATTTTGGTCTGTCCAAGATTATGGATGATGATAGCTATGGT
GTAGATGGAATGGATCTAACTTCCCAGGGGGCAGGCACTTACTGGTATTTACCTCCTGAG
TGTTTTGTAGTTGGAAAAGAGCCACCAAAGATTTCCAACAAGGTTGATGTATGGTCGGTT
GGAGTCATCTTCTTTCAGTGTCTTTATGGTAGAAAGCCATTTGGTCACAATCAATCTCAA
CAAGACATTCTTCAAGAAAATACAATATTAAAAGCCACAGAAGTCCAGTTCCCTGTAAAA
CCGGTTGTAAGCAGTGAAGCCAAGGCATTTATAAGACGCTGTTTGGCATATCGAAAAGAA
GATCGATTTGATGTGCACCAGCTGGCAAATGACCCATACCTTCTCCCACACATGAGAAGA
TCAAATTCTTCAGGAAACCTACACATGGCTGGGCTGACAGCATCCCCTACACCCCCTTCT
TCAAGCATAATTACTTACTGA
Protein Properties
Number of Residues 766
Molecular Weight 86698.9
Theoretical pI 9.01
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • None
Protein Sequence
>Serine/threonine-protein kinase tousled-like 1
MSVQSSSGSLEGPPSWSQLSTSPTPGSAAAARSLLNHTPPSGRPREGAMDELHSLDPRRQ
ELLEARFTGVASGSTGSTGSCSVGAKASTNNESSNHSFGSLGSLSDKESETPEKKQSESS
RGRKRKAENQNESSQGKSIGGRGHKISDYFEYQGGNGSSPVRGIPPAIRSPQNSHSHSTP
SSSVRPNSPSPTALAFGDHPIVQPKQLSFKIIQTDLTMLKLAALESNKIQDLEKKEGRID
DLLRANCDLRRQIDEQQKLLEKYKERLNKCISMSKKLLIEKSTQEKLSSREKSMQDRLRL
GHFTTVRHGASFTEQWTDGFAFQNLVKQQEWVNQQREDIERQRKLLAKRKPPTANNSQAP
STNSEPKQRKNKAVNGAENDPFVRPNLPQLLTLAEYHEQEEIFKLRLGHLKKEEAEIQAE
LERLERVRNLHIRELKRINNEDNSQFKDHPTLNERYLLLHLLGRGGFSEVYKAFDLYEQR
YAAVKIHQLNKSWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDTFCTVLEY
CEGNDLDFYLKQHKLMSEKEARSIVMQIVNALRYLNEIKPPIIHYDLKPGNILLVDGTAC
GEIKITDFGLSKIMDDDSYGVDGMDLTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSV
GVIFFQCLYGRKPFGHNQSQQDILQENTILKATEVQFPVKPVVSSEAKAFIRRCLAYRKE
DRFDVHQLANDPYLLPHMRRSNSSGNLHMAGLTASPTPPSSSIITY
GenBank ID Protein 33636698
UniProtKB/Swiss-Prot ID Q9UKI8
UniProtKB/Swiss-Prot Entry Name TLK1_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_012290.4
GeneCard ID TLK1
GenAtlas ID TLK1
HGNC ID HGNC:11841
References
General References
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  10. Sillje HH, Takahashi K, Tanaka K, Van Houwe G, Nigg EA: Mammalian homologues of the plant Tousled gene code for cell-cycle-regulated kinases with maximal activities linked to ongoing DNA replication. EMBO J. 1999 Oct 15;18(20):5691-702. [PubMed:10523312 ]
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