| Identification |
|---|
| HMDB Protein ID
| HMDBP01550 |
| Secondary Accession Numbers
| |
| Name
| Cytochrome P450 4F12 |
| Synonyms
|
- CYPIVF12
|
| Gene Name
| CYP4F12 |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Involved in monooxygenase activity |
| Specific Function
| Catalyzes leukotriene B4 omega-hydroxylation and arachidonic acid omega-hydroxylation but with an activity much lower than that of CYP4F2. Catalyzes the hydroxylation of the antihistamine ebastine.
|
| Pathways
|
Not Available
|
| Reactions
|
| RH + reduced flavoprotein + Oxygen → ROH + oxidized flavoprotein + Water |
details
|
|
| GO Classification
|
| Biological Process |
| very long-chain fatty acid metabolic process |
| drug metabolic process |
| xenobiotic metabolic process |
| renal water homeostasis |
| sodium ion homeostasis |
| epoxygenase P450 pathway |
| pressure natriuresis |
| negative regulation of blood coagulation |
| vitamin E metabolic process |
| vitamin K biosynthetic process |
| Cellular Component |
| endoplasmic reticulum membrane |
| apical plasma membrane |
| integral to membrane |
| Function |
| ion binding |
| cation binding |
| metal ion binding |
| binding |
| catalytic activity |
| transition metal ion binding |
| electron carrier activity |
| iron ion binding |
| monooxygenase activity |
| heme binding |
| oxidoreductase activity |
| Molecular Function |
| electron carrier activity |
| aromatase activity |
| iron ion binding |
| heme binding |
| alkane 1-monooxygenase activity |
| arachidonic acid epoxygenase activity |
| leukotriene-B4 20-monooxygenase activity |
| vitamin-K-epoxide reductase (warfarin-sensitive) activity |
|
| Cellular Location
|
- Endoplasmic reticulum membrane
- Multi-pass membrane protein
- Multi-pass membrane protein
- Microsome membrane
|
| Gene Properties |
|---|
| Chromosome Location
| 19 |
| Locus
| 19p13.1 |
| SNPs
| CYP4F12 |
| Gene Sequence
|
>1575 bp
ATGTCGCTGCTGAGCCTGCCCTGGCTGGGCCTCAGACCGGTGGCAATGTCCCCATGGCTA
CTCCTGCTGCTGGTTGTGGGCTCCTGGCTACTCGCCCGCATCCTGGCTTGGACCTATGCC
TTCTATAACAACTGCCGCCGGCTCCAGTGTTTCCCACAGCCCCCAAAACGGAACTGGTTT
TGGGGTCACCTGGGCCTGATCACTCCTACAGAGGAGGGCTTGAAGGACTCGACCCAGATG
TCGGCCACCTATTCCCAGGGCTTTACGGTATGGCTGGGTCCCATCATCCCCTTCATCGTT
TTATGCCACCCTGACACCATCCGGTCTATCACCAATGCCTCAGCTGCCATTGCACCCAAG
GATAATCTCTTCATCAGGTTCCTGAAGCCCTGGCTGGGAGAAGGGATACTGCTGAGTGGC
GGTGACAAGTGGAGCCGCCACCGTCGGATGCTGACGCCCGCCTTCCATTTCAACATCCTG
AAGTCCTATATAACGATCTTCAACAAGAGTGCAAACATCATGCTTGACAAGTGGCAGCAC
CTGGCCTCAGAGGGCAGCAGTCGTCTGGACATGTTTGAGCACATCAGCCTCATGACCTTG
GACAGTCTACAGAAATGCATCTTCAGCTTTGACAGCCATTGTCAGGAGAGGCCCAGTGAA
TATATTGCCACCATCTTGGAGCTCAGTGCCCTTGTAGAGAAAAGAAGCCAGCATATCCTC
CAGCACATGGACTTTCTGTATTACCTCTCCCATGACGGGCGGCGCTTCCACAGGGCCTGC
CGCCTGGTGCATGACTTCACAGACGCTGTCATCCGGGAGCGGCGTCGCACCCTCCCCACT
CAGGGTATTGATGATTTTTTCAAAGACAAAGCCAAGTCCAAGACTTTGGATTTCATTGAT
GTGCTTCTGCTGAGCAAGGATGAAGATGGGAAGGCATTGTCAGATGAGGATATAAGAGCA
GAGGCTGACACCTTCATGTTTGGAGGCCATGACACCACGGCCAGTGGCCTCTCCTGGGTC
CTGTACAACCTTGCGAGGCACCCAGAATACCAGGAGCGCTGCCGACAGGAGGTGCAAGAG
CTTCTGAAGGACCGCGATCCTAAAGAGATTGAATGGGACGACCTGGCCCAGCTGCCCTTC
CTGACCATGTGCGTGAAGGAGAGCCTGAGGTTACATCCCCCAGCTCCCTTCATCTCCCGA
TGCTGCACCCAGGACATTGTTCTCCCAGATGGCCGAGTCATCCCCAAAGGCATTACCTGC
CTCATCGATATTATAGGGGTCCATCACAACCCAACTGTGTGGCCGGATCCTGAGGTCTAC
GACCCCTTCCGCTTTGACCCAGAGAACAGCAAGGGGAGGTCACCTCTGGCTTTTATTCCT
TTCTCCGCAGGGCCCAGGAACTGCATCGGGCAGGCGTTCGCCATGGCGGAGATGAAAGTG
GTCCTGGCGTTGATGCTGCTGCACTTCCGGTTCCTGCCAGACCACACTGAGCCCCGCAGG
AAGCTGGAATTGATCATGCGCGCCGAGGGCGGGCTTTGGCTGCGGGTGGAGCCCCTGAAT
GTAGGCTTGCAGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 524 |
| Molecular Weight
| 60308.195 |
| Theoretical pI
| 7.551 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Cytochrome P450 4F12
MSLLSLPWLGLRPVAMSPWLLLLLVVGSWLLARILAWTYAFYNNCRRLQCFPQPPKRNWF
WGHLGLITPTEEGLKDSTQMSATYSQGFTVWLGPIIPFIVLCHPDTIRSITNASAAIAPK
DNLFIRFLKPWLGEGILLSGGDKWSRHRRMLTPAFHFNILKSYITIFNKSANIMLDKWQH
LASEGSSRLDMFEHISLMTLDSLQKCIFSFDSHCQERPSEYIATILELSALVEKRSQHIL
QHMDFLYYLSHDGRRFHRACRLVHDFTDAVIRERRRTLPTQGIDDFFKDKAKSKTLDFID
VLLLSKDEDGKALSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQE
LLKDRDPKEIEWDDLAQLPFLTMCVKESLRLHPPAPFISRCCTQDIVLPDGRVIPKGITC
LIDIIGVHHNPTVWPDPEVYDPFRFDPENSKGRSPLAFIPFSAGPRNCIGQAFAMAEMKV
VLALMLLHFRFLPDHTEPRRKLELIMRAEGGLWLRVEPLNVGLQ
|
| External Links |
|---|
| GenBank ID Protein
| 11275334 |
| UniProtKB/Swiss-Prot ID
| Q9HCS2 |
| UniProtKB/Swiss-Prot Entry Name
| CP4FC_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AB035130 |
| GeneCard ID
| CYP4F12 |
| GenAtlas ID
| CYP4F12 |
| HGNC ID
| HGNC:18857 |
| References |
|---|
| General References
| - Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. Genome Res. 2003 Oct;13(10):2265-70. Epub 2003 Sep 15. [PubMed:12975309 ]
- Bylund J, Bylund M, Oliw EH: cDna cloning and expression of CYP4F12, a novel human cytochrome P450. Biochem Biophys Res Commun. 2001 Jan 26;280(3):892-7. [PubMed:11162607 ]
- Hashizume T, Imaoka S, Hiroi T, Terauchi Y, Fujii T, Miyazaki H, Kamataki T, Funae Y: cDNA cloning and expression of a novel cytochrome p450 (cyp4f12) from human small intestine. Biochem Biophys Res Commun. 2001 Feb 2;280(4):1135-41. [PubMed:11162645 ]
|
