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Identification
HMDB Protein ID HMDBP01585
Secondary Accession Numbers
  • 6881
Name Phosphatidylinositol-glycan-specific phospholipase D
Synonyms
  1. GPI-PLD
  2. GPI-specific phospholipase D
  3. Glycoprotein phospholipase D
  4. Glycosyl-phosphatidylinositol-specific phospholipase D
  5. PI-G PLD
Gene Name GPLD1
Protein Type Enzyme
Biological Properties
General Function Involved in glycosylphosphatidylinositol phospholipase D activity
Specific Function This protein hydrolyzes the inositol phosphate linkage in proteins anchored by phosphatidylinositol glycans (GPI-anchor) thus releasing these proteins from the membrane.
Pathways
  • Glycosylphosphatidylinositol (GPI)-anchor biosynthesis
Reactions
6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + Water → 6-(alpha-D-Glucosaminyl)-1D-myo-inositol + phosphatidate details
+ Water → 6-(alpha-D-glucosaminyl)-1D-myo-inositol + Phosphatidate details
GO Classification
Biological Process
positive regulation of apoptotic process
cellular response to calcium ion
cellular response to drug
cellular response to pH
cell migration involved in sprouting angiogenesis
cellular response to triglyceride
chondrocyte differentiation
complement receptor mediated signaling pathway
GPI anchor release
hematopoietic stem cell migration to bone marrow
negative regulation of triglyceride catabolic process
positive regulation of alkaline phosphatase activity
positive regulation of cytolysis
positive regulation of glucose metabolic process
positive regulation of insulin secretion involved in cellular response to glucose stimulus
positive regulation of membrane protein ectodomain proteolysis
regulation of cellular response to insulin stimulus
transepithelial transport
positive regulation of high-density lipoprotein particle clearance
cellular response to cholesterol
insulin receptor signaling pathway
positive regulation of endothelial cell migration
phosphatidylcholine metabolic process
positive regulation of triglyceride biosynthetic process
response to glucose stimulus
ossification
negative regulation of cell proliferation
Cellular Component
cytoplasmic part
proteinaceous extracellular matrix
extracellular space
intracellular membrane-bounded organelle
Component
extracellular region
Function
hydrolase activity, acting on ester bonds
catalytic activity
hydrolase activity
phospholipase d activity
glycosylphosphatidylinositol phospholipase d activity
lipase activity
phospholipase activity
Molecular Function
glycosylphosphatidylinositol phospholipase D activity
sodium channel regulator activity
Cellular Location
  1. Secreted
Gene Properties
Chromosome Location 6
Locus 6p22.1
SNPs GPLD1
Gene Sequence
>2523 bp
ATGTCTGCTTTCAGGTTGTGGCCTGGCCTGCTGATCATGTTGGGTTCTCTCTGCCATAGA
GGTTCACCGTGTGGCCTTTCAACACACATAGAAATAGGACACAGAGCTCTGGAGTTTCTT
CAGCTTCACAATGGGCGTGTTAACTACAGAGAGCTGTTACTAGAACACCAGGATGCGTAT
CAGGCTGGAATCGTGTTTCCTGATTGTTTTTACCCTAGCATCTGCAAAGGAGGAAAATTC
CATGATGTGTCTGAGAGCACTCACTGGACTCCGTTTCTTAATGCAAGCGTTCATTATATC
CGAGAGAACTATCCCCTTCCCTGGGAGAAGGACACAGAGAAACTGGTAGCTTTCTTGTTT
GGAATTACTTCTCACATGGCGGCAGATGTCAGCTGGCATAGTCTGGGCCTTGAACAAGGA
TTCCTTAGGACCATGGGAGCTATTGATTTTCACGGCTCCTATTCAGAGGCTCATTCGGCT
GGTGATTTTGGAGGAGATGTGTTGAGCCAGTTTGAATTTAATTTTAATTACCTTGCACGA
CGCTGGTATGTGCCAGTCAAAGATCTACTGGGAATTTATGAGAAACTGTATGGTCGAAAA
GTCATCACCGAAAATGTAATCGTTGATTGTTCACATATCCAGTTCTTAGAAATGTATGGT
GAGATGCTAGCTGTTTCCAAGTTATATCCCACTTACTCTACAAAGTCCCCGTTTTTGGTG
GAACAATTCCAAGAGTATTTTCTTGGAGGACTGGATGATATGGCATTTTGGTCCACTAAT
ATTTACCATCTAACAAGCTTCATGTTGGAGAATGGGACCAGTGACTGCAACCTGCCTGAG
AACCCTCTGTTCATTGCATGTGGCGGCCAGCAAAACCACACCCAGGGCTCAAAAATGCAG
AAAAATGATTTTCACAGAAATTTGACTACATCCCTAACTGAAAGTGTTGACAGGAATATA
AACTATACTGAAAGAGGAGTGTTCTTTAGTGTAAATTCCTGGACCCCGGATTCCATGTCC
TTTATCTACAAGGCTTTGGAAAGGAACATAAGGACAATGTTCATAGGTGGCTCTCAGTTG
TCACAAAAGCACGTCTCCAGCCCCTTAGCATCTTACTTCTTGTCATTTCCTTATGCGAGG
CTTGGCTGGGCAATGACCTCAGCTGACCTCAACCAGGATGGGCACGGTGACCTCGTGGTG
GGCGCACCAGGCTACAGCCGCCCCGGCCACATCCACATCGGGCGCGTGTACCTCATCTAC
GGCAATGACCTGGGCCTGCCACCTGTTGACCTGGACCTGGACAAGGAGGCCCACAGGATC
CTTGAAGGCTTCCAGCCCTCAGGTCGGTTTGGCTCGGCCTTGGCTGTGTTGGACTTTAAC
GTGGACGGCGTGCCTGACCTGGCCGTGGGAGCTCCCTCGGTGGGCTCCGAGCAGCTCACC
TACAAAGGTGCCGTGTATGTCTACTTTGGTTCCAAACAAGGAGGAATGTCTTCTTCCCCT
AACATCACCATTTCTTGCCAGGACATCTACTGTAACTTGGGCTGGACTCTCTTGGCTGCA
GATGTGAATGGAGACAGTGAACCCGATCTGGTCATCGGCTCCCCTTTTGCACCAGGTGGA
GGGAAGCAGAAGGGAATTGTGGCTGCGTTTTATTCTGGCCCCAGCCTGAGCGACAAAGAA
AAACTGAACGTGGAGGCAGCCAACTGGACGGTGAGAGGCGAGGAAGACTTCTCCTGGTTT
GGATATTCCCTTCACGGTGTCACTGTGGACAACAGAACCTTGCTGTTGGTTGGGAGCCCG
ACCTGGAAGAATGCCAGCAGGCTGGGCCATTTGTTACACATCCGAGATGAGAAAAAGAGC
CTTGGGAGGGTGTATGGCTACTTCCCACCAAACGGCCAAAGCTGGTTTACCATTTCTGGA
GACAAGGCAATGGGGAAACTGGGTACTTCCCTTTCCAGTGGCCACGTACTGATGAATGGG
ACTCTGAAACAAGTGCTGCTGGTTGGAGCCCCTACGTACGATGACGTGTCTAAGGTGGCA
TTCCTGACCGTGACCCTACACCAAGGCGGAGCCACTCGCATGTACGCACTCATATCTGAC
GCGCAGCCTCTGCTGCTCAGCACCTTCAGCGGAGACCGCCGCTTCTCCCGATTTGGTGGC
GTTCTGCACTTGAGTGACCTGGATGATGATGGCTTAGATGAAATCATCATGGCAGCCCCC
CTGAGGATAGCAGATGTAACCTCTGGACTGATTGGGGGAGAAGACGGCCGAGTATATGTA
TATAATGGCAAAGAGACCACCCTTGGTGACATGACTGGCAAATGCAAATCATGGATAACT
CCATGTCCAGAAGAAAAGGCCCAATATGTATTGATTTCTCCTGAAGCCAGCTCAAGGTTT
GGGAGCTCCCTCATCACCGTGAGGTCCAAGGCAAAGAACCAAGTCGTCATTGCTGCTGGA
AGGAGTTCTTTGGGAGCCCGACTCTCCGGGGCACTTCACGTCTATAGCCTTGGCTCAGAT
TGA
Protein Properties
Number of Residues 840
Molecular Weight 92335.705
Theoretical pI 6.362
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>Phosphatidylinositol-glycan-specific phospholipase D
MSAFRLWPGLLIMLGSLCHRGSPCGLSTHVEIGHRALEFLQLHNGRVNYRELLLEHQDAY
QAGIVFPDCFYPSICKGGKFHDVSESTHWTPFLNASVHYIRENYPLPWEKDTEKLVAFLF
GITSHMAADVSWHSLGLEQGFLRTMGAIDFHGSYSEAHSAGDFGGDVLSQFEFNFNYLAR
RWYVPVKDLLGIYEKLYGRKVITENVIVDCSHIQFLEMYGEMLAVSKLYPTYSTKSPFLV
EQFQEYFLGGLDDMAFWSTNIYHLTSFMLENGTSDCNLPENPLFIACGGQQNHTQGSKMQ
KNDFHRNLTTSLTESVDRNINYTERGVFFSVNSWTPDSMSFIYKALERNIRTMFIGGSQL
SQKHVSSPLASYFLSFPYARLGWAMTSADLNQDGHGDLVVGAPGYSRPGHIHIGRVYLIY
GNDLGLPPVDLDLDKEAHRILEGFQPSGRFGSALAVLDFNVDGVPDLAVGAPSVGSEQLT
YKGAVYVYFGSKQGGMSSSPNITISCQDIYCNLGWTLLAADVNGDSEPDLVIGSPFAPGG
GKQKGIVAAFYSGPSLSDKEKLNVEAANWTVRGEEDFSWFGYSLHGVTVDNRTLLLVGSP
TWKNASRLGHLLHIRDEKKSLGRVYGYFPPNGQSWFTISGDKAMGKLGTSLSSGHVLMNG
TLKQVLLVGAPTYDDVSKVAFLTVTLHQGGATRMYALTSDAQPLLLSTFSGDRRFSRFGG
VLHLSDLDDDGLDEIIMAAPLRIADVTSGLIGGEDGRVYVYNGKETTLGDMTGKCKSWIT
PCPEEKAQYVLISPEASSRFGSSLITVRSKAKNQVVIAAGRSSLGARLSGALHVYSLGSD
GenBank ID Protein 20269065
UniProtKB/Swiss-Prot ID P80108
UniProtKB/Swiss-Prot Entry Name PHLD_HUMAN
PDB IDs Not Available
GenBank Gene ID AJ308108
GeneCard ID GPLD1
GenAtlas ID GPLD1
HGNC ID HGNC:4459
References
General References
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  2. Chen R, Jiang X, Sun D, Han G, Wang F, Ye M, Wang L, Zou H: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. J Proteome Res. 2009 Feb;8(2):651-61. doi: 10.1021/pr8008012. [PubMed:19159218 ]
  3. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  4. Liu T, Qian WJ, Gritsenko MA, Camp DG 2nd, Monroe ME, Moore RJ, Smith RD: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. J Proteome Res. 2005 Nov-Dec;4(6):2070-80. [PubMed:16335952 ]
  5. Schofield JN, Rademacher TW: Structure and expression of the human glycosylphosphatidylinositol phospholipase D1 (GPLD1) gene. Biochim Biophys Acta. 2000 Nov 15;1494(1-2):189-94. [PubMed:11072085 ]
  6. Hoener MC, Brodbeck U: Phosphatidylinositol-glycan-specific phospholipase D is an amphiphilic glycoprotein that in serum is associated with high-density lipoproteins. Eur J Biochem. 1992 Jun 15;206(3):747-57. [PubMed:1606959 ]