Showing Protein Ecto-NOX disulfide-thiol exchanger 2 (HMDBP01690)

• 7027

1. APK1 antigen
2. Cytosolic ovarian carcinoma antigen 1
3. Hydroquinone [NADH] oxidase
4. Protein disulfide-thiol oxidoreductase
5. Tumor-associated hydroquinone oxidase
6. tNOX

1. Cell membrane
2. Secreted
3. extracellular space

>1833 bp
ATGCAAAGAGATTTTAGATGGCTGTGGGTCTACGAAATAGGCTATGCAGCCGATAACAGT
AGAACTCTGAACGTGGATTCCACTGCAATGACACTACCTATGTCTGATCCAACTGCATGG
GCCACAGCAATGAATAATCTTGGAATGGCACCGCTGGGAATTGCCGGACAACCAATTTTA
CCTGACTTTGATCCTGCTCTTGGAATGATGACTGGAATTCCACCAATAACTCCAATGATG
CCTGGTTTGGGAATAGTACCTCCACCAATTCCTCCAGATATGCCAGTAGTAAAAGAGATC
ATACACTGTAAAAGCTGCACGCTCTTCCCTCCAAATCCAAATCTCCCACCTCCTGCAACC
CGAGAAAGACCACCAGGATGCAAAACAGTATTTGTGGGTGGTCTGCCTGAAAATGGGACA
GAGCAAATCATTGTGGAAGTTTTCGAGCAGTGTGGAGAGATCATTGCCATTCGCAAGAGC
AAGAAGAACTTCTGCCACATTCGCTTTGCTGAGGAGTACATGGTGGACAAAGCCCTGTAT
CTGTCTGGTTACCGCATTCGCCTGGGCTCTAGTACTGACAAGAAGGACACAGGCAGACTC
CACGTTGATTTCGCACAGGCTCGAGATGACCTGTATGAGTGGGAGTGTAAACAGCGTATG
CTAGCCAGAGAGGAGCGCCATCGTAGAAGAATGGAAGAAGAAAGATTGCGTCCACCATCT
CCACCCCCAGTGGTCCACTATTCAGATCATGAATGCAGCATTGTTGCTGAAAAATTAAAA
GATGATTCCAAATTCTCAGAAGCTGTACAGACCTTGCTTACCTGGATAGAGCGAGGAGAG
GTCAACCGTCGTAGCGCCAATAACTTCTACTCCATGATCCAGTCGGCCAACAGCCATGTC
CGCCGCCTGGTGAACGAGAAAGCTGCCCATGAGAAAGATATGGAAGAAGCAAAGGAGAAG
TTCAAGCAGGCCCTTTCTGGAATTCTCATTCAATTTGAGCAGATAGTGGCTGTGTACCAT
TCCGCCTCCAAGCAGAAGGCATGGGACCACTTCACAAAAGCCCAGCGGAAGAACATCAGC
GTGTGGTGCAAACAAGCTGAGGAAATTCGCAACATTCATAATGATGAATTAATGGGAATC
AGGCGAGAAGAAGAAATGGAAATGTCTGATGATGAAATAGAAGAAATGACAGAAACAAAA
GAAACTGAGGAATCAGCCTTAGTATCACAGGCAGAAGCTCTGAAGGAAGAAAATGACAGC
CTCCGTTGGCAGCTCGATGCCTACCGGAATGAAGTAGAACTGCTCAAGCAAGAACAAGGC
AAAGTCCACAGAGAAGATGACCCTAACAAAGAACAGCAGCTGAAACTCCTGCAACAAGCC
CTGCAAGGAATGCAACAGCATCTACTCAAAGTCCAAGAGGAATACAAAAAGAAAGAAGCT
GAACTTGAAAAACTCAAAGATGACAAGTTACAGGTGGAAAAAATGTTGGAAAATCTTAAA
GAAAAGGAAAGCTGTGCTTCTAGGCTGTGTGCCTCAAACCAGGATAGCGAATACCCTCTT
GAGAAGACCATGAACAGCAGTCCTATCAAATCTGAACGTGAAGCACTGCTAGTGGGGATT
ATCTCCACATTCCTTCATGTTCACCCATTTGGAGCAAGCATTGAATACATCTGTTCCTAC
TTGCACCGTCTTGATAATAAGATCTGCACCAGCGATGTGGAGTGTCTCATGGGTAGACTC
CAGCATACCTTCAAGCAGGAAATGACTGGAGTTGGAGCCAGCCTGGAAAAGAGATGGAAA
TTCTGTGGCTTCGAGGGCTTGAAGCTGACCTAA

• RRM_1 (PF00076 )

• None

• None

>Ecto-NOX disulfide-thiol exchanger 2
MQRDFRWLWVYEIGYAADNSRTLNVDSTAMTLPMSDPTAWATAMNNLGMAPLGIAGQPIL
PDFDPALGMMTGIPPITPMMPGLGIVPPPIPPDMPVVKEIIHCKSCTLFPPNPNLPPPAT
RERPPGCKTVFVGGLPENGTEQIIVEVFEQCGEIIAIRKSKKNFCHIRFAEEYMVDKALY
LSGYRIRLGSSTDKKDTGRLHVDFAQARDDLYEWECKQRMLAREERHRRRMEEERLRPPS
PPPVVHYSDHECSIVAEKLKDDSKFSEAVQTLLTWIERGEVNRRSANNFYSMIQSANSHV
RRLVNEKAAHEKDMEEAKEKFKQALSGILIQFEQIVAVYHSASKQKAWDHFTKAQRKNIS
VWCKQAEEIRNIHNDELMGIRREEEMEMSDDEIEEMTETKETEESALVSQAEALKEENDS
LRWQLDAYRNEVELLKQEQGKVHREDDPNKEQQLKLLQQALQGMQQHLLKVQEEYKKKEA
ELEKLKDDKLQVEKMLENLKEKESCASRLCASNQDSEYPLEKTMNSSPIKSEREALLVGI
ISTFLHVHPFGASIEYICSYLHRLDNKICTSDVECLMGRLQHTFKQEMTGVGASLEKRWK
FCGFEGLKLT

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4. Chueh PJ, Kim C, Cho N, Morre DM, Morre DJ: Molecular cloning and characterization of a tumor-associated, growth-related, and time-keeping hydroquinone (NADH) oxidase (tNOX) of the HeLa cell surface. Biochemistry. 2002 Mar 19;41(11):3732-41. [PubMed:11888291 ]
5. Yantiri F, Morre DJ: Isolation and characterization of a tumor-associated NADH oxidase (tNOX) from the HeLa cell surface. Arch Biochem Biophys. 2001 Jul 15;391(2):149-59. [PubMed:11437345 ]
6. Chang K, Pastan I: Molecular cloning and expression of a cDNA encoding a protein detected by the K1 antibody from an ovarian carcinoma (OVCAR-3) cell line. Int J Cancer. 1994 Apr 1;57(1):90-7. [PubMed:8150545 ]
7. Dai S, Morre DJ, Geilen CC, Almond-Roesler B, Orfanos CE, Morre DM: Inhibition of plasma membrane NADH oxidase activity and growth of HeLa cells by natural and synthetic retinoids. Mol Cell Biochem. 1997 Jan;166(1-2):101-9. [PubMed:9046026 ]
8. Morre DJ, Chueh PJ, Lawler J, Morre DM: The sulfonylurea-inhibited NADH oxidase activity of HeLa cell plasma membranes has properties of a protein disulfide-thiol oxidoreductase with protein disulfide-thiol interchange activity. J Bioenerg Biomembr. 1998 Oct;30(5):477-87. [PubMed:9932650 ]
9. Kishi T, Morre DM, Morre DJ: The plasma membrane NADH oxidase of HeLa cells has hydroquinone oxidase activity. Biochim Biophys Acta. 1999 May 26;1412(1):66-77. [PubMed:10354495 ]
10. Kelker M, Kim C, Chueh PJ, Guimont R, Morre DM, Morre DJ: Cancer isoform of a tumor-associated cell surface NADH oxidase (tNOX) has properties of a prion. Biochemistry. 2001 Jun 26;40(25):7351-4. [PubMed:11412089 ]
11. Morre DJ, Sedlak D, Tang X, Chueh PJ, Geng T, Morre DM: Surface NADH oxidase of HeLa cells lacks intrinsic membrane binding motifs. Arch Biochem Biophys. 2001 Aug 15;392(2):251-6. [PubMed:11488599 ]
12. Cho N, Chueh PJ, Kim C, Caldwell S, Morre DM, Morre DJ: Monoclonal antibody to a cancer-specific and drug-responsive hydroquinone (NADH) oxidase from the sera of cancer patients. Cancer Immunol Immunother. 2002 May;51(3):121-9. Epub 2002 Feb 27. [PubMed:11941450 ]
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