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Identification
HMDB Protein ID HMDBP01698
Secondary Accession Numbers
  • 7036
Name Beta-1,3-galactosyltransferase 2
Synonyms
  1. Beta-1,3-GalTase 2
  2. Beta3Gal-T2
  3. Beta3GalT2
  4. UDP-galactose:2-acetamido-2-deoxy-D-glucose 3beta-galactosyltransferase 2
Gene Name B3GALT2
Protein Type Unknown
Biological Properties
General Function Involved in galactosyltransferase activity
Specific Function Beta-1,3-galactosyltransferase that transfers galactose from UDP-galactose to substrates with a terminal beta-N- acetylglucosamine (beta-GlcNAc) residue. Can also utilize substrates with a terminal galactose residue, albeit with lower efficiency. Involved in the biosynthesis of the carbohydrate moieties of glycolipids and glycoproteins. Inactive towards substrates with terminal alpha-N-acetylglucosamine (alpha-GlcNAc) or alpha-N-acetylgalactosamine (alpha-GalNAc) residues
Pathways Not Available
Reactions Not Available
GO Classification
Component
membrane
cell part
Function
galactosyltransferase activity
catalytic activity
transferase activity
transferase activity, transferring hexosyl groups
transferase activity, transferring glycosyl groups
Process
metabolic process
macromolecule metabolic process
macromolecule modification
protein modification process
protein amino acid glycosylation
Cellular Location
  1. Golgi apparatus membrane
  2. Single-pass type II membrane protein (Probable)
Gene Properties
Chromosome Location Chromosome:1
Locus 1q31
SNPs B3GALT2
Gene Sequence
>1269 bp
ATGCTTCAGTGGAGGAGAAGACACTGCTGCTTTGCAAAGATGACCTGGAATGCCAAAAGG
TCTCTGTTCCGCACTCATCTTATTGGAGTACTTTCTCTAGTGTTTCTTTTTGCTATGTTT
TTGTTTTTCAATCATCATGACTGGCTGCCAGGCAGAGCTGGATTCAAAGAAAACCCTGTG
ACATACACTTTCCGAGGATTTCGGTCAACAAAAAGTGAGACAAACCACAGCTCCCTTCGG
AACATTTGGAAAGAAACAGTCCCTCAAACCCTGAGGCCTCAAACAGCAACTAACTCTAAT
AACACAGACCTGTCACCACAAGGAGTTACAGGCCTGGAGAATACACTTAGTGCCAATGGA
AGTATTTACAATGAAAAAGGTACTGGACATCCAAATTCTTACCATTTCAAATATATTATT
AATGAGCCTGAAAAATGCCAAGAGAAAAGTCCTTTTTTAATACTACTAATAGCTGCAGAG
CCTGGACAAATAGAAGCTAGAAGAGCTATTCGGCGAACTTGGGGCAATGAAAGTCTAGCA
CCTGGTATTCAAATCACAAGAATATTTTTGTTGGGCTTAAGTATTAAGCTAAATGGCTAC
CTTCAACGTGCAATACTGGAAGAAAGCAGACAATATCATGATATAATTCAACAGGAATAC
TTAGATACGTACTATAATTTGACCATTAAAACACTAATGGGCATGAACTGGGTTGCAACA
TACTGTCCACATATTCCATATGTTATGAAAACTGACAGTGACATGTTTGTCAACACTGAA
TATTTAATCAATAAGTTACTGAAGCCAGATCTGCCTCCCAGACATAACTATTTCACTGGT
TACCTAATGCGAGGATATGCACCCAATCGAAACAAAGATAGCAAGTGGTACATGCCACCA
GACCTCTACCCAAGTGAGCGTTATCCTGTCTTCTGTTCTGGAACTGGTTATGTTTTTTCT
GGAGATCTGGCAGAAAAGATTTTTAAAGTTTCTTTAGGTATCCGCCGTTTGCACTTGGAA
GATGTATATGTAGGGATCTGTCTTGCCAAGTTGAGAATTGATCCTGTACCCCCTCCCAAT
GAGTTTGTGTTCAATCACTGGCGAGTCTCTTATTCGAGCTGTAAATACAGCCACCTAATT
ACCTCTCATCAGTTCCAGCCTAGTGAACTGATAAAATACTGGAACCATTTACAACAAAAT
AAGCACAATGCCTGTGCCAACGCAGCAAAAGAAAAGGCAGGCAGGTATCGCCACCGTAAA
CTACATTAG
Protein Properties
Number of Residues 422
Molecular Weight 49213.1
Theoretical pI 9.81
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • 25-45
Protein Sequence
>Beta-1,3-galactosyltransferase 2
MLQWRRRHCCFAKMTWNAKRSLFRTHLIGVLSLVFLFAMFLFFNHHDWLPGRAGFKENPV
TYTFRGFRSTKSETNHSSLRNIWKETVPQTLRPQTATNSNNTDLSPQGVTGLENTLSANG
SIYNEKGTGHPNSYHFKYIINEPEKCQEKSPFLILLIAAEPGQIEARRAIRQTWGNESLA
PGIQITRIFLLGLSIKLNGYLQRAILEESRQYHDIIQQEYLDTYYNLTIKTLMGMNWVAT
YCPHIPYVMKTDSDMFVNTEYLINKLLKPDLPPRHNYFTGYLMRGYAPNRNKDSKWYMPP
DLYPSERYPVFCSGTGYVFSGDLAEKIFKVSLGIRRLHLEDVYVGICLAKLRIDPVPPPN
EFVFNHWRVSYSSCKYSHLITSHQFQPSELIKYWNHLQQNKHNACANAAKEKAGRYRHRK
LH
GenBank ID Protein 12620190
UniProtKB/Swiss-Prot ID O43825
UniProtKB/Swiss-Prot Entry Name B3GT2_HUMAN
PDB IDs Not Available
GenBank Gene ID AF288390
GeneCard ID B3GALT2
GenAtlas ID B3GALT2
HGNC ID HGNC:917
References
General References
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  6. Kolbinger F, Streiff MB, Katopodis AG: Cloning of a human UDP-galactose:2-acetamido-2-deoxy-D-glucose 3beta-galactosyltransferase catalyzing the formation of type 1 chains. J Biol Chem. 1998 Jan 2;273(1):433-40. [PubMed:9417100 ]