Showing Protein Beta-2-glycoprotein 1 (HMDBP01717)

• 7059

1. APC inhibitor
2. Activated protein C-binding protein
3. Anticardiolipin cofactor
4. Apo-H
5. Apolipoprotein H
6. B2GPI
7. Beta(2)GPI
8. Beta-2-glycoprotein I

1. Secreted

>1038 bp
ATGATTTCTCCAGTGCTCATCTTGTTCTCGAGTTTTCTCTGCCATGTTGCTATTGCAGGA
CGGACCTGTCCCAAGCCAGATGATTTACCATTTTCCACAGTGGTCCCGTTAAAAACATTC
TATGAGCCAGGAGAAGAGATTACGTATTCCTGCAAGCCGGGCTATGTGTCCCGAGGAGGG
ATGAGAAAGTTTATCTGCCCTCTCACAGGACTGTGGCCCATCAACACTCTGAAATGTACA
CCCAGAGTATGTCCTTTTGCTGGAATCTTAGAAAATGGAGCCGTACGCTATACGACTTTT
GAATATCCCAACACGATCAGTTTTTCTTGTAACACTGGGTTTTATCTGAATGGCGCTGAT
TCTGCCAAGTGCACTGAGGAAGGAAAATGGAGCCCGGAGCTTCCTGTCTGTGCTCCCATC
ATCTGCCCTCCACCATCCATACCTACGTTTGCAACACTTCGTGTTTATAAGCCATCAGCT
GGAAACAATTCCCTCTATCGGGACACAGCAGTTTTTGAATGTTTGCCACAACATGCGATG
TTTGGAAATGATACAATTACCTGCACGACACATGGAAATTGGACTAAATTACCAGAATGC
AGGGAAGTAAAATGCCCATTCCCATCAAGACCAGACAATGGATTTGTGAACTATCCTGCA
AAACCAACACTTTATTACAAGGATAAAGCCACATTTGGCTGCCATGATGGATATTCTCTG
GATGGCCCGGAAGAAATAGAATGTACCAAACTGGGAAACTGGTCTGCCATGCCAAGTTGT
AAAGCATCTTGTAAATTACCTGTGAAAAAAGCCACTGTGGTGTACCAAGGAGAGAGAGTA
AAGATTCAGGAAAAATTTAAGAATGGAATGCTACATGGTGATAAAGTTTCTTTCTTCTGC
AAAAATAAGGAAAAGAAGTGTAGCTATACAGAGGATGCTCAGTGTATAGATGGCACTATC
GAAGTCCCCAAATGCTTCAAGGAACACAGTTCTCTGGCTTTTTGGAAAACTGATGCATCC
GATGTAAAGCCATGCTAA

• Sushi (PF00084 )
• Sushi_2 (PF09014 )

• 1-19

• None

>Beta-2-glycoprotein 1
MISPVLILFSSFLCHVAIAGRTCPKPDDLPFSTVVPLKTFYEPGEEITYSCKPGYVSRGG
MRKFICPLTGLWPINTLKCTPRVCPFAGILENGAVRYTTFEYPNTISFSCNTGFYLNGAD
SAKCTEEGKWSPELPVCAPIICPPPSIPTFATLRVYKPSAGNNSLYRDTAVFECLPQHAM
FGNDTITCTTHGNWTKLPECREVKCPFPSRPDNGFVNYPAKPTLYYKDKATFGCHDGYSL
DGPEEIECTKLGNWSAMPSCKASCKVPVKKATVVYQGERVKIQEKFKNGMLHGDKVSFFC
KNKEKKCSYTEDAQCIDGTIEVPKCFKEHSSLAFWKTDASDVKPC

• 1C1Z

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4. Liu T, Qian WJ, Gritsenko MA, Camp DG 2nd, Monroe ME, Moore RJ, Smith RD: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. J Proteome Res. 2005 Nov-Dec;4(6):2070-80. [PubMed:16335952 ]
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7. Kristiansen TZ, Bunkenborg J, Gronborg M, Molina H, Thuluvath PJ, Argani P, Goggins MG, Maitra A, Pandey A: A proteomic analysis of human bile. Mol Cell Proteomics. 2004 Jul;3(7):715-28. Epub 2004 Apr 14. [PubMed:15084671 ]
8. Nilsson J, Ruetschi U, Halim A, Hesse C, Carlsohn E, Brinkmalm G, Larson G: Enrichment of glycopeptides for glycan structure and attachment site identification. Nat Methods. 2009 Nov;6(11):809-11. doi: 10.1038/nmeth.1392. Epub 2009 Oct 18. [PubMed:19838169 ]
9. Steinkasserer A, Estaller C, Weiss EH, Sim RB, Day AJ: Complete nucleotide and deduced amino acid sequence of human beta 2-glycoprotein I. Biochem J. 1991 Jul 15;277 ( Pt 2):387-91. [PubMed:1650181 ]
10. Kristensen T, Schousboe I, Boel E, Mulvihill EM, Hansen RR, Moller KB, Moller NP, Sottrup-Jensen L: Molecular cloning and mammalian expression of human beta 2-glycoprotein I cDNA. FEBS Lett. 1991 Sep 9;289(2):183-6. [PubMed:1655523 ]
11. Mehdi H, Nunn M, Steel DM, Whitehead AS, Perez M, Walker L, Peeples ME: Nucleotide sequence and expression of the human gene encoding apolipoprotein H (beta 2-glycoprotein I). Gene. 1991 Dec 15;108(2):293-8. [PubMed:1748314 ]
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14. Okkels H, Rasmussen TE, Sanghera DK, Kamboh MI, Kristensen T: Structure of the human beta2-glycoprotein I (apolipoprotein H) gene. Eur J Biochem. 1999 Jan;259(1-2):435-40. [PubMed:9914524 ]
15. Lozier J, Takahashi N, Putnam FW: Complete amino acid sequence of human plasma beta 2-glycoprotein I. Proc Natl Acad Sci U S A. 1984 Jun;81(12):3640-4. [PubMed:6587378 ]
16. Matsuura E, Igarashi Y, Fujimoto M, Ichikawa K, Suzuki T, Sumida T, Yasuda T, Koike T: Heterogeneity of anticardiolipin antibodies defined by the anticardiolipin cofactor. J Immunol. 1992 Jun 15;148(12):3885-91. [PubMed:1602135 ]
17. McNeil HP, Simpson RJ, Chesterman CN, Krilis SA: Anti-phospholipid antibodies are directed against a complex antigen that includes a lipid-binding inhibitor of coagulation: beta 2-glycoprotein I (apolipoprotein H). Proc Natl Acad Sci U S A. 1990 Jun;87(11):4120-4. [PubMed:2349221 ]
18. Aleporou-Marinou V, Pappa H, Yalouris P, Patargias T: Purification of apolipoprotein H (beta 2-glycoprotein I)-like protein from human follicular fluid. Comp Biochem Physiol B Biochem Mol Biol. 2001 Mar;128(3):537-42. [PubMed:11250549 ]
19. Steinkasserer A, Barlow PN, Willis AC, Kertesz Z, Campbell ID, Sim RB, Norman DG: Activity, disulphide mapping and structural modelling of the fifth domain of human beta 2-glycoprotein I. FEBS Lett. 1992 Nov 23;313(2):193-7. [PubMed:1426288 ]
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22. Schwarzenbacher R, Zeth K, Diederichs K, Gries A, Kostner GM, Laggner P, Prassl R: Crystal structure of human beta2-glycoprotein I: implications for phospholipid binding and the antiphospholipid syndrome. EMBO J. 1999 Nov 15;18(22):6228-39. [PubMed:10562535 ]
23. Steinkasserer A, Dorner C, Wurzner R, Sim RB: Human beta 2-glycoprotein I: molecular analysis of DNA and amino acid polymorphism. Hum Genet. 1993 May;91(4):401-2. [PubMed:8099061 ]
24. Sanghera DK, Kristensen T, Hamman RF, Kamboh MI: Molecular basis of the apolipoprotein H (beta 2-glycoprotein I) protein polymorphism. Hum Genet. 1997 Jul;100(1):57-62. [PubMed:9225969 ]
25. Sanghera DK, Wagenknecht DR, McIntyre JA, Kamboh MI: Identification of structural mutations in the fifth domain of apolipoprotein H (beta 2-glycoprotein I) which affect phospholipid binding. Hum Mol Genet. 1997 Feb;6(2):311-6. [PubMed:9063752 ]