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Identification
HMDB Protein ID HMDBP01805
Secondary Accession Numbers
  • 7163
Name Centromere protein R
Synonyms
  1. Beta-3-endonexin
  2. CENP-R
  3. Integrin beta-3-binding protein
  4. Nuclear receptor-interacting factor 3
Gene Name ITGB3BP
Protein Type Enzyme
Biological Properties
General Function Involved in protein C-terminus binding
Specific Function Transcription coregulator that can have both coactivator and corepressor functions. Isoform 1, but not other isoforms, is involved in the coactivation of nuclear receptors for retinoid X (RXRs) and thyroid hormone (TRs) in a ligand-dependent fashion. In contrast, it does not coactivate nuclear receptors for retinoic acid, vitamin D, progesterone receptor, nor glucocorticoid. Acts as a coactivator for estrogen receptor alpha. Acts as a transcriptional corepressor via its interaction with the NFKB1 NF- kappa-B subunit, possibly by interfering with the transactivation domain of NFKB1. Induces apoptosis in breast cancer cells, but not in other cancer cells, via a caspase-2 mediated pathway that involves mitochondrial membrane permeabilization but does not require other caspases. May also act as an inhibitor of cyclin A- associated kinase. Also acts a component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex
Pathways Not Available
Reactions Not Available
GO Classification Not Available
Cellular Location
  1. Isoform 4:Cytoplasm
Gene Properties
Chromosome Location Chromosome:1
Locus 1p31.3
SNPs ITGB3BP
Gene Sequence
>534 bp
ATGCCTGTTAAAAGATCACTGAAGTTGGATGGTCTGTTAGAAGAAAATTCATTTGATCCT
TCAAAAATCACAAGGAAGAAAAGTGTTATAACTTATTCTCCAACAACTGGAACTTGTCAA
ATGAGTCTATTTGCTTCTCCCACAAGTTCTGAAGAGCAAAAGCACAGAAATGGACTATCA
AATGAAAAGAGAAAAAAATTGAATCACCCCAGTTTAACTGAAAGCAAAGAATCTACAACA
AAAGACAATGATGAATTCATGATGTTGCTATCAAAAGTTGAGAAATTGTCAGAAGAAATC
ATGGAGATAATGCAAAATTTAAGTAGTATACAGGCTTTGGAGGGCAGTAGAGAGCTTGAA
AATCTCATTGGAATCTCCTGTGCATCACATTTCTTAAAAAGAGAAATGCAGAAAACCAAA
GAACTAATGACAAAAGTGAATAAACAAAAACTGTTTGAAAAGAGTACAGGACTTCCTCAC
AAAGCATCACGTCATCTTGACAGCTATGAATTCCTTAAAGCCATTTTAAACTGA
Protein Properties
Number of Residues 177
Molecular Weight 20194.0
Theoretical pI 9.7
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • None
Protein Sequence
>Centromere protein R
MPVKRSLKLDGLLEENSFDPSKITRKKSVITYSPTTGTCQMSLFASPTSSEEQKHRNGLS
NEKRKKLNHPSLTESKESTTKDNDEFMMLLSKVEKLSEEIMEIMQNLSSIQALEGSRELE
NLIGISCASHFLKREMQKTKELMTKVNKQKLFEKSTGLPHKASRHLDSYEFLKAILN
GenBank ID Protein 6002985
UniProtKB/Swiss-Prot ID Q13352
UniProtKB/Swiss-Prot Entry Name CENPR_HUMAN
PDB IDs Not Available
GenBank Gene ID AF175306
GeneCard ID ITGB3BP
GenAtlas ID ITGB3BP
HGNC ID HGNC:6157
References
General References
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  4. Dephoure N, Zhou C, Villen J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP: A quantitative atlas of mitotic phosphorylation. Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10762-7. doi: 10.1073/pnas.0805139105. Epub 2008 Jul 31. [PubMed:18669648 ]
  5. Daub H, Olsen JV, Bairlein M, Gnad F, Oppermann FS, Korner R, Greff Z, Keri G, Stemmann O, Mann M: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. Mol Cell. 2008 Aug 8;31(3):438-48. doi: 10.1016/j.molcel.2008.07.007. [PubMed:18691976 ]
  6. Shattil SJ, O'Toole T, Eigenthaler M, Thon V, Williams M, Babior BM, Ginsberg MH: Beta 3-endonexin, a novel polypeptide that interacts specifically with the cytoplasmic tail of the integrin beta 3 subunit. J Cell Biol. 1995 Nov;131(3):807-16. [PubMed:7593198 ]
  7. Li D, Desai-Yajnik V, Lo E, Schapira M, Abagyan R, Samuels HH: NRIF3 is a novel coactivator mediating functional specificity of nuclear hormone receptors. Mol Cell Biol. 1999 Oct;19(10):7191-202. [PubMed:10490654 ]
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  9. Kashiwagi H, Schwartz MA, Eigenthaler M, Davis KA, Ginsberg MH, Shattil SJ: Affinity modulation of platelet integrin alphaIIbbeta3 by beta3-endonexin, a selective binding partner of the beta3 integrin cytoplasmic tail. J Cell Biol. 1997 Jun 16;137(6):1433-43. [PubMed:9182673 ]
  10. Ohtoshi A, Maeda T, Higashi H, Ashizawa S, Yamada M, Hatakeyama M: beta3-endonexin as a novel inhibitor of cyclin A-associated kinase. Biochem Biophys Res Commun. 2000 Jan 27;267(3):947-52. [PubMed:10673397 ]
  11. Li D, Wang F, Samuels HH: Domain structure of the NRIF3 family of coregulators suggests potential dual roles in transcriptional regulation. Mol Cell Biol. 2001 Dec;21(24):8371-84. [PubMed:11713274 ]
  12. Besta F, Massberg S, Brand K, Muller E, Page S, Gruner S, Lorenz M, Sadoul K, Kolanus W, Lengyel E, Gawaz M: Role of beta(3)-endonexin in the regulation of NF-kappaB-dependent expression of urokinase-type plasminogen activator receptor. J Cell Sci. 2002 Oct 15;115(Pt 20):3879-88. [PubMed:12244126 ]
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  14. Talukder AH, Gururaj A, Mishra SK, Vadlamudi RK, Kumar R: Metastasis-associated protein 1 interacts with NRIF3, an estrogen-inducible nuclear receptor coregulator. Mol Cell Biol. 2004 Aug;24(15):6581-91. [PubMed:15254226 ]
  15. Okada M, Cheeseman IM, Hori T, Okawa K, McLeod IX, Yates JR 3rd, Desai A, Fukagawa T: The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres. Nat Cell Biol. 2006 May;8(5):446-57. Epub 2006 Apr 16. [PubMed:16622420 ]
  16. Foltz DR, Jansen LE, Black BE, Bailey AO, Yates JR 3rd, Cleveland DW: The human CENP-A centromeric nucleosome-associated complex. Nat Cell Biol. 2006 May;8(5):458-69. Epub 2006 Apr 16. [PubMed:16622419 ]