Showing Protein Tenascin-R (HMDBP01975)
| Identification | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| HMDB Protein ID | HMDBP01975 | |||||||||
| Secondary Accession Numbers |
|
|||||||||
| Name | Tenascin-R | |||||||||
| Synonyms |
|
|||||||||
| Gene Name | TNR | |||||||||
| Protein Type | Unknown | |||||||||
| Biological Properties | ||||||||||
| General Function | Involved in receptor binding | |||||||||
| Specific Function | Neural extracellular matrix (ECM) protein involved in interactions with different cells and matrix components. These interactions can influence cellular behavior by either evoking a stable adhesion and differentiation, or repulsion and inhibition of neurite growth. Binding to cell surface gangliosides inhibits RGD-dependent integrin-mediated cell adhesion and results in an inhibition of PTK2 (FAK) phosphorylation and cell detachment. Binding to membrane surface sulfatides results in a oligodendrocyte adhesion and differentiation. Interaction with CNTN1 induces a repulsion of neurons and an inhibition of neurite outgrowth. Interacts with SCN2B may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier. TNR-linked chondroitin sulfate glycosaminoglycans are involved in the interaction with FN1 and mediate inhibition of cell adhesion and neurite outgrowth. The highly regulated addition of sulfated carbohydrate structure may modulate the adhesive properties of TNR over the course of development and during synapse maintenance | |||||||||
| Pathways | Not Available | |||||||||
| Reactions | Not Available | |||||||||
| GO Classification |
|
|||||||||
| Cellular Location |
|
|||||||||
| Gene Properties | ||||||||||
| Chromosome Location | Chromosome:1 | |||||||||
| Locus | 1q24 | |||||||||
| SNPs | TNR | |||||||||
| Gene Sequence |
>4077 bp ATGGGGGCAGATGGGGAAACAGTGGTTCTGAAGAACATGCTCATTGGCGTCAACCTGATC CTTCTGGGCTCCATGATCAAGCCTTCAGAGTGTCAGCTGGAGGTCACCACAGAAAGGGTC CAGAGACAGTCAGTGGAGGAGGAGGGAGGCATTGCCAACTACAACACGTCCAGCAAAGAG CAGCCTGTGGTCTTCAACCACGTGTACAACATTAACGTGCCCTTGGACAACCTCTGCTCC TCAGGGCTAGAGGCCTCTGCTGAGCAGGAGGTGAGTGCAGAAGACGAGACTCTGGCAGAG TACATGGGCCAGACCTCAGACCACGAGAGCCAGGTTACCTTTACACACAGGATCAACTTC CCCAAAAAGGCCTGTCCATGTGCCAGTTCAGCCCAGGTGCTGCAGGAGCTGCTGAGCCGG ATCGAGATGCTGGAGAGGGAGGTGTCGGTGCTGCGAGACCAGTGCAACGCCAACTGCTGC CAAGAAAGTGCTGCCACAGGACAACTGGACTATATCCCTCACTGCAGCGGCCACGGCAAC TTTAGCTTTGAGTCCTGTGGCTGCATCTGCAACGAAGGCTGGTTTGGCAAGAATTGCTCG GAGCCCTACTGCCCGCTGGGTTGCTCCAGCCGGGGGGTGTGTGTGGATGGCCAGTGCATC TGTGACAGCGAGTACAGCGGGGATGACTGTTCCGAACTCCGGTGCCCAACAGACTGCAGC TCCCGGGGGCTCTGCGTGGACGGTGAGTGTGTCTGTGAAGAGCCCTACACTGGCGAGGAC TGCAGGGAACTGAGGTGCCCTGGGGACTGTTCGGGGAAGGGGAGATGTGCCAACGGTACC TGTTTATGCGAGGAGGGCTACGTTGGTGAGGACTGCGGCCAGCGGCAGTGTCTGAATGCC TGCAGTGGGCGAGGACAATGTGAGGAGGGGCTCTGCGTCTGTGAAGAGGGCTACCAGGGC CCTGACTGCTCAGCAGTTGCCCCTCCAGAGGACTTGCGAGTGGCTGGTATCAGCGACAGG TCCATTGAGCTGGAATGGGACGGGCCGATGGCAGTGACGGAATATGTGATCTCTTACCAG CCGACGGCCCTGGGGGGCCTCCAGCTCCAGCAGCGGGTGCCTGGAGATTGGAGTGGTGTC ACCATCACGGAGCTGGAGCCAGGTCTCACCTACAACATCAGCGTCTACGCTGTCATTAGC AACATCCTCAGCCTTCCCATCACTGCCAAGGTGGCCACCCATCTCTCCACTCCTCAAGGG CTACAATTTAAGACGATCACAGAGACCACCGTGGAGGTGCAGTGGGAGCCCTTCTCATTT TCCTTCGATGGGTGGGAAATCAGCTTCATTCCAAAGAACAATGAAGGGGGAGTGATTGCT CAGGTCCCCAGCGATGTTACGTCCTTTAACCAGACAGGACTAAAGCCTGGGGAGGAATAC ATTGTCAATGTGGTGGCTCTGAAAGAACAGGCCCGCAGCCCCCCTACCTCGGCCAGCGTC TCCACAGTCATTGACGGCCCCACGCAGATCCTGGTTCGCGATGTCTCGGACACCGTGGCT TTTGTGGAGTGGATTCCCCCTCGAGCCAAAGTCGATTTCATTCTTTTGAAATATGGCCTG GTGGGCGGGGAAGGTGGGAGGACCACCTTCCGGCTGCAGCCTCCCCTGAGCCAATACTCA GTGCAGGCCCTGCGGCCTGGCTCCCGATACGAGGTGTCAGTCAGTGCCGTCCGAGGGACC AACGAGAGCGATTCTGCCACCACTCAGTTCACAACAGAGATCGATGCCCCCAAGAACTTG CGAGTTGGTTCTCGCACAGCAACCAGCCTTGACCTCGAGTGGGATAACAGTGAAGCCGAA GTTCAGGAGTACAAGGTTGTGTACATCACCCTGGCGGGTGAGCAATATCATGAGGTACTG GTCCCCAGGGGCATTGGTCCAACCACCAGGGCCACCCTGACAGATCTGGTACCTGGCACT GAGTATGGAGTTGGAATATCTGCCGTCATGAACTCACAGCAAAGCGTGCCAGCCACCATG AATGCCAGGACTGAACTTGACAGTCCCCGAGACCTCATGGTGACAGCCTCCTCGGAGACC TCCATCTCCCTCATCTGGACCAAGGCCAGTGGCCCCATTGACCACTACCGAATTACCTTT ACCCCATCCTCTGGGATTGCCTCAGAAGTCACCGTACCCAAGGACAGGACCTCATACACA CTAACAGATCTAGAGCCTGGGGCAGAGTACATCATTTCCGTCACTGCTGAGAGGGGTCGG CAGCAGAGCTTGGAGTCCACTGTGGATGCTTTCACAGGCTTCCGTCCCATCTCTCATCTG CACTTTTCTCATGTGACCTCCTCCAGTGTGAACATCACTTGGAGTGATCCATCTCCCCCA GCAGACAGACTCATTCTTAACTACAGCCCCAGGGATGAGGAGGAAGAGATGATGGAGGTC TCCCTGGATGCCACCAAGAGGCATGCTGTCCTGATGGGCCTGCAACCAGCCACAGAGTAT ATTGTGAACCTTGTGGCTGTCCATGGCACAGTGACCTCTGAGCCCATTGTGGGCTCCATC ACCACAGGAATTGATCCCCCAAAAGACATCACAATTAGCAATGTGACCAAGGACTCAGTG ATGGTCTCCTGGAGCCCTCCTGTTGCATCTTTCGATTACTACCGAGTATCATATCGACCC ACCCAAGTGGGACGACTAGACAGCTCAGTGGTGCCCAACACTGTGACAGAATTCACCATC ACCAGACTGAACCCAGCTACCGAATACGAAATCAGCCTCAACAGCGTGCGGGGCAGGGAG GAAAGCGAGCGCATCTGTACTCTTGTGCACACAGCCATGGACAACCCTGTGGATCTGATT GCTACCAATATCACTCCAACAGAAGCCCTGCTGCAGTGGAAGGCACCAGTGGGTGAGGTG GAGAACTACGTCATTGTTCTTACACACTTTGCAGTCGCTGGAGAGACCATCCTTGTTGAC GGAGTCAGTGAGGAATTTCGGCTTGTTGACCTGCTTCCTAGCACCCACTATACTGCCACC ATGTATGCCACCAATGGACCTCTCACCAGTGGCACCATCAGCACCAACTTTTCTACTCTC CTGGACCCTCCGGCAAACCTGACAGCCAGTGAAGTCACCAGACAAAGTGCCCTGATCTCC TGGCAGCCTCCCAGGGCAGAGATTGAAAATTATGTCTTGACCTACAAATCCACCGACGGA AGCCGCAAGGAGCTGATTGTGGATGCAGAAGACACCTGGATTCGACTGGAGGGCCTGTTG GAGAACACAGACTACACGGTGCTCCTGCAGGCAGCACAGGACACCACGTGGAGCAGCATC ACCTCCACCGCTTTCACCACAGGAGGCCGGGTGTTCCCTCATCCCCAAGACTGTGCCCAG CATTTGATGAATGGAGACACTTTGAGTGGGGTTTACCCCATCTTCCTCAATGGGGAGCTG AGCCAGAAATTACAAGTGTACTGTGATATGACCACCGACGGGGGCGGCTGGATTGTATTC CAGAGGCGGCAGAATGGCCAAACTGATTTTTTCCGGAAATGGGCTGATTACCGTGTTGGC TTCGGGAACGTGGAGGATGAGTTCTGGCTGGGGCTGGACAATATACACAGGATCACATCC CAGGGCCGCTATGAGCTGCGCGTGGACATGCGGGATGGCCAGGAGGCCGCCTTCGCCTCC TACGACAGGTTCTCTGTCGAGGACAGCAGAAACCTGTACAAACTCCGCATAGGAAGCTAC AACGGCACTGCGGGGGACTCCCTCAGCTATCATCAAGGACGCCCTTTCTCCACAGAGGAT AGAGACAATGATGTTGCAGTGACTAACTGTGCCATGTCGTACAAGGGAGCATGGTGGTAT AAGAACTGCCACCGGACCAACCTCAATGGGAAGTACGGGGAGTCCAGGCACAGTCAGGGC ATCAACTGGTACCATTGGAAAGGCCATGAGTTCTCCATCCCCTTTGTGGAAATGAAGATG CGCCCCTACAACCACCGTCTCATGGCAGGGAGAAAACGGCAGTCCTTACAGTTCTGA |
|||||||||
| Protein Properties | ||||||||||
| Number of Residues | 1358 | |||||||||
| Molecular Weight | 149546.7 | |||||||||
| Theoretical pI | 4.44 | |||||||||
| Pfam Domain Function | ||||||||||
| Signals |
|
|||||||||
| Transmembrane Regions |
|
|||||||||
| Protein Sequence |
>Tenascin-R MGADGETVVLKNMLIGVNLILLGSMIKPSECQLEVTTERVQRQSVEEEGGIANYNTSSKE QPVVFNHVYNINVPLDNLCSSGLEASAEQEVSAEDETLAEYMGQTSDHESQVTFTHRINF PKKACPCASSAQVLQELLSRIEMLEREVSVLRDQCNANCCQESAATGQLDYIPHCSGHGN FSFESCGCICNEGWFGKNCSEPYCPLGCSSRGVCVDGQCICDSEYSGDDCSELRCPTDCS SRGLCVDGECVCEEPYTGEDCRELRCPGDCSGKGRCANGTCLCEEGYVGEDCGQRQCLNA CSGRGQCEEGLCVCEEGYQGPDCSAVAPPEDLRVAGISDRSIELEWDGPMAVTEYVISYQ PTALGGLQLQQRVPGDWSGVTITELEPGLTYNISVYAVISNILSLPITAKVATHLSTPQG LQFKTITETTVEVQWEPFSFSFDGWEISFIPKNNEGGVIAQVPSDVTSFNQTGLKPGEEY IVNVVALKEQARSPPTSASVSTVIDGPTQILVRDVSDTVAFVEWIPPRAKVDFILLKYGL VGGEGGRTTFRLQPPLSQYSVQALRPGSRYEVSVSAVRGTNESDSATTQFTTEIDAPKNL RVGSRTATSLDLEWDNSEAEVQEYKVVYSTLAGEQYHEVLVPRGIGPTTRATLTDLVPGT EYGVGISAVMNSQQSVPATMNARTELDSPRDLMVTASSETSISLIWTKASGPIDHYRITF TPSSGIASEVTVPKDRTSYTLTDLEPGAEYIISVTAERGRQQSLESTVDAFTGFRPISHL HFSHVTSSSVNITWSDPSPPADRLILNYSPRDEEEEMMEVSLDATKRHAVLMGLQPATEY IVNLVAVHGTVTSEPIVGSITTGIDPPKDITISNVTKDSVMVSWSPPVASFDYYRVSYRP TQVGRLDSSVVPNTVTEFTITRLNPATEYEISLNSVRGREESERICTLVHTAMDNPVDLI ATNITPTEALLQWKAPVGEVENYVIVLTHFAVAGETILVDGVSEEFRLVDLLPSTHYTAT MYATNGPLTSGTISTNFSTLLDPPANLTASEVTRQSALISWQPPRAEIENYVLTYKSTDG SRKELIVDAEDTWIRLEGLLENTDYTVLLQAAQDTTWSSITSTAFTTGGRVFPHPQDCAQ HLMNGDTLSGVYPIFLNGELSQKLQVYCDMTTDGGGWIVFQRRQNGQTDFFRKWADYRVG FGNVEDEFWLGLDNIHRITSQGRYELRVDMRDGQEAAFASYDRFSVEDSRNLYKLRIGSY NGTAGDSLSYHQGRPFSTEDRDNDVAVTNCAMSYKGAWWYKNCHRTNLNGKYGESRHSQG INWYHWKGHEFSIPFVEMKMRPYNHRLMAGRKRQSLQF |
|||||||||
| External Links | ||||||||||
| GenBank ID Protein | 1617316 | |||||||||
| UniProtKB/Swiss-Prot ID | Q92752 | |||||||||
| UniProtKB/Swiss-Prot Entry Name | TENR_HUMAN | |||||||||
| PDB IDs | ||||||||||
| GenBank Gene ID | X98085 | |||||||||
| GeneCard ID | TNR | |||||||||
| GenAtlas ID | TNR | |||||||||
| HGNC ID | HGNC:11953 | |||||||||
| References | ||||||||||
| General References |
|
|||||||||