Showing Protein Sodium/nucleoside cotransporter 2 (HMDBP02043)

• 7522

1. CNT 2
2. Concentrative nucleoside transporter 2
3. Na(+)/nucleoside cotransporter 2
4. SPNT
5. Sodium-coupled nucleoside transporter 2
6. Sodium/purine nucleoside co-transporter
7. Solute carrier family 28 member 2
8. hCNT2

• Azathioprine Action Pathway
• Mercaptopurine Action Pathway
• Mercaptopurine Metabolism Pathway
• Thioguanine Action Pathway

1. Membrane
2. Multi-pass membrane protein

>1977 bp
ATGGAGAAAGCAAGTGGAAGACAGTCCATTGCTCTGTCCACAGTGGAGACTGGCACAGTG
AACCCGGGGCTGGAGCTCATGGAAAAAGAAGTAGAGCCTGAGGGAAGCAAGAGGACTGAC
GCACAAGGACACAGCCTGGGGGATGGACTGGGCCCTTCCACTTACCAGAGGAGGAGTCGG
TGGCCTTTCAGCAAAGCAAGAAGTTTCTGCAAAACACACGCCAGCTTGTTCAAGAAGATC
CTGTTGGGCCTGTTGTGTTTGGCCTATGCTGCCTATCTCCTGGCAGCTTGCATCTTGAAT
TTCCAGAGGGCACTGGCCTTGTTTGTCATCACCTGCTTGGTGATCTTTGTCCTGGTTCAC
TCGTTTTTGAAAAAGCTCCTGGGCAAAAAATTAACAAGATGTCTGAAGCCCTTTGAAAAC
TCCCGCCTGAGGCTTTGGACGAAATGGGTGTTTGCAGGAGTCTCCTTGGTTGGCCTTATA
CTGTGGTTGGCTTTAGACACAGCCCAAAGGCCAGAGCAGCTGATCCCCTTTGCAGGAATC
TGCATGTTCATCCTTATCCTCTTTGCCTGCTCCAAACACCACAGCGCAGTGTCCTGGAGG
ACAGTGTTTTCGGGCCTAGGTCTTCAATTTGTCTTTGGGATCTTGGTCATCAGAACTGAT
CTTGGATATACTGTATTTCAGTGGCTGGGAGAGCAGGTCCAGATTTTCCTGAACTACACT
GTGGCCGGCTCCAGTTTTGTCTTTGGGGATACACTGGTCAAGGATGTCTTTGCTTTTCAG
GCCTTACCAATCATCATTTTCTTTGGATGTGTGGTGTCCATTCTCTACTACCTGGGCCTT
GTGCAATGGGTAGTTCAGAAGGTCGCCTGGTTTTTACAAATCACTATGGGCACCACTGCT
ACAGAGACCCTGGCTGTGGCAGGAAACATCTTTGTGGGTATGACAGAGGCACCTCTGCTC
ATCCGTCCCTACCTTGGGGACATGACACTCTCTGAAATCCATGCGGTGATGACTGGAGGG
TTTGCCACCATTTCTGGCACTGTGCTGGGAGCCTTCATAGCCTTTGGGGTTGATGCATCA
TCCCTGATTTCTGCCTCTGTGATGGCCGCCCCTTGTGCTCTCGCCTCATCAAAGCTAGCG
TATCCGGAAGTGGAGGAGTCCAAGTTCAAGAGTGAGGAGGGGGTAAAGCTGCCCCGTGGG
AAGGAGAGGAATGTCCTGGAAGCTGCCAGCAACGGAGCCGTAGATGCCATAGGCCTTGCT
ACTAATGTAGCAGCCAACCTGATTGCCTTTTTGGCTGTGTTGGCCTTCATCAATGCTGCC
CTCTCCTGGCTGGGGGAATTGGTGGACATACAGGGGCTCACTTTCCAGGTCATCTGCTCC
TATCTCCTAAGGCCCATGGTTTTCATGATGGGTGTAGAATGGACAGACTGTCCAATGGTG
GCTGAGATGGTGGGAATCAAGTTCTTCATAAATGAATTTGTTGCTTATCAGCAACTGTCT
CAATACAAGAACAAACGTCTCTCTGGAATGGAGGAGTGGATTGAGGGAGAGAAACAGTGG
ATTTCTGTGAGAGCTGAAATCATTACAACATTTTCACTCTGTGGATTTGCCAATCTTAGT
TCCATAGGAATCACACTTGGAGGCTTGACATCAATAGTACCTCACCGGAAGAGTGACTTG
TCCAAGGTTGTGGTCAGGGCCCTCTTCACAGGGGCCTGTGTATCCCTTATCAGTGCCTGT
ATGGCAGGAATCCTCTATGTCCCCAGGGGAGCTGAAGCTGACTGTGTCTCCTTCCCAAAC
ACAAGTTTCACCAATAGAACCTATGAGACCTACATGTGCTGCAGAGGGCTCTTTCAGAGT
ACTTCTCTGAATGGCACCAACCCTCCTTCTTTTTCTGGTCCCTGGGAAGATAAGGAGTTC
AGTGCTATGGCCCTTACTAACTGCTGTGGATTCTACAACAATACCGTCTGTGCCTGA

• Gate (PF07670 )
• Nucleos_tra2_C (PF07662 )
• Nucleos_tra2_N (PF01773 )

>Sodium/nucleoside cotransporter 2
MEKASGRQSIALSTVETGTVNPGLELMEKEVEPEGSKRTDAQGHSLGDGLGPSTYQRRSR
WPFSKARSFCKTHASLFKKILLGLLCLAYAAYLLAACILNFQRALALFVITCLVIFVLVH
SFLKKLLGKKLTRCLKPFENSRLRLWTKWVFAGVSLVGLILWLALDTAQRPEQLIPFAGI
CMFILILFACSKHHSAVSWRTVFSGLGLQFVFGILVIRTDLGYTVFQWLGEQVQIFLNYT
VAGSSFVFGDTLVKDVFAFQALPIIIFFGCVVSILYYLGLVQWVVQKVAWFLQITMGTTA
TETLAVAGNIFVGMTEAPLLIRPYLGDMTLSEIHAVMTGGFATISGTVLGAFIAFGVDAS
SLISASVMAAPCALASSKLAYPEVEESKFKSEEGVKLPRGKERNVLEAASNGAVDAIGLA
TNVAANLIAFLAVLAFINAALSWLGELVDIQGLTFQVICSYLLRPMVFMMGVEWTDCPMV
AEMVGIKFFINEFVAYQQLSQYKNKRLSGMEEWIEGEKQWISVRAEIITTFSLCGFANLS
SIGITLGGLTSIVPHRKSDLSKVVVRALFTGACVSLISACMAGILYVPRGAEADCVSFPN
TSFTNRTYETYMCCRGLFQSTSLNGTNPPSFSGPWEDKEFSAMALTNCCGFYNNTVCA

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3. Loewen SK, Ng AM, Yao SY, Cass CE, Baldwin SA, Young JD: Identification of amino acid residues responsible for the pyrimidine and purine nucleoside specificities of human concentrative Na(+) nucleoside cotransporters hCNT1 and hCNT2. J Biol Chem. 1999 Aug 27;274(35):24475-84. [PubMed:10455109 ]
4. Wang J, Su SF, Dresser MJ, Schaner ME, Washington CB, Giacomini KM: Na(+)-dependent purine nucleoside transporter from human kidney: cloning and functional characterization. Am J Physiol. 1997 Dec;273(6 Pt 2):F1058-65. [PubMed:9435697 ]
5. Ritzel MW, Yao SY, Ng AM, Mackey JR, Cass CE, Young JD: Molecular cloning, functional expression and chromosomal localization of a cDNA encoding a human Na+/nucleoside cotransporter (hCNT2) selective for purine nucleosides and uridine. Mol Membr Biol. 1998 Oct-Dec;15(4):203-11. [PubMed:10087507 ]
6. Owen RP, Gray JH, Taylor TR, Carlson EJ, Huang CC, Kawamoto M, Johns SJ, Stryke D, Ferrin TE, Giacomini KM: Genetic analysis and functional characterization of polymorphisms in the human concentrative nucleoside transporter, CNT2. Pharmacogenet Genomics. 2005 Feb;15(2):83-90. [PubMed:15861032 ]
7. Li L, Tan CM, Koo SH, Chong KT, Lee EJ: Identification and functional analysis of variants in the human concentrative nucleoside transporter 2, hCNT2 (SLC28A2) in Chinese, Malays and Indians. Pharmacogenet Genomics. 2007 Sep;17(9):783-6. [PubMed:17700367 ]