Showing Protein Apolipoprotein A-IV precursor (HMDBP02093)

• 7575

1. Apo-AIV
2. ApoA-IV

1. Secreted

>1191 bp
ATGTTCCTGAAGGCCGTGGTCCTGACCCTGGCCCTGGTGGCTGTCGCCGGAGCCAGGGCT
GAGGTCAGTGCTGACCAGGTGGCCACAGTGATGTGGGACTACTTCAGCCAGCTGAGCAAC
AATGCCAAGGAGGCCGTGGAACATCTCCAGAAATCTGAACTCACCCAGCAACTCAATGCC
CTCTTCCAGGACAAACTTGGAGAAGTGAACACTTACGCAGGTGACCTGCAGAAGAAGCTG
GTGCCCTTTGCCACCGAGCTGCATGAACGCCTGGCCAAGGACTCGGAGAAACTGAAGGAG
GAGATTGGGAAGGAGCTGGAGGAGCTGAGGGCCCGGCTGCTGCCCCATGCCAATGAGGTG
AGCCAGAAGATCGGGGACAACCTGCGAGAGCTTCAGCAGCGCCTGGAGCCCTACGCGGAC
CAGCTGCGCACCCAGGTCAACACGCAGGCCGAGCAGCTGCGGCGCCAGCTGGACCCCCTA
GCACAGCGCATGGAGAGAGTGCTGCGGGAGAACGCCGACAGCCTGCAGGCCTCGCTGAGG
CCCCACGCCGACGAGCTCAAGGCCAAGATCGACCAGAACGTGGAGGAGCTCAAGGGACGC
CTTACGCCCTACGCTGACGAATTCAAAGTCAAGATTGACCAGACCGTGGAGGAGCTGCGC
CGCAGCCTGGCTCCCTATGCTCAGGACACGCAGGAGAAGCTCAACCACCAGCTTGAGGGC
CTGACCTTCCAGATGAAGAAGAACGCCGAGGAGCTCAAGGCCAGGATCTCGGCCAGTGCC
GAGGAGCTGCGGCAGAGGCTGGCGCCCTTGGCCGAGGACGTGCGTGGCAACCTGAAGGGC
AACACCGAGGGGCTGCAGAAGTCACTGGCAGAGCTGGGTGGGCACCTGGACCAGCAGGTG
GAGGAGTTCCGACGCCGGGTGGAGCCCTACGGGGAAAACTTCAACAAAGCCCTGGTGCAG
CAGATGGAACAGCTCAGGCAGAAACTGGGCCCCCATGCGGGGGACGTGGAAGGCCACTTG
AGCTTCCTGGAGAAGGACCTGAGGGACAAGGTCAACTCCTTCTTCAGCACCTTCAAGGAG
AAAGAGAGCCAGGACAAGACTCTCTCCCTCCCTGAGCTGGAGCAACAGCAGGAACAGCAG
CAGGAGCAGCAGCAGGAGCAGGTGCAGATGCTGGCCCCTTTGGAGAGCTGA

• Apolipoprotein (PF01442 )

• 1-20

>Apolipoprotein A-IV precursor
MFLKAVVLTLALVAVAGARAEVSADQVATVMWDYFSQLSNNAKEAVEHLQKSELTQQLNA
LFQDKLGEVNTYAGDLQKKLVPFATELHERLAKDSEKLKEEIGKELEELRARLLPHANEV
SQKIGDNLRELQQRLEPYADQLRTQVNTQAEQLRRQLTPYAQRMERVLRENADSLQASLR
PHADELKAKIDQNVEELKGRLTPYADEFKVKIDQTVEELRRSLAPYAQDTQEKLNHQLEG
LTFQMKKNAEELKARISASAEELRQRLAPLAEDVRGNLRGNTEGLQKSLAELGGHLDQQV
EEFRRRVEPYGENFNKALVQQMEQLRQKLGPHAGDVEGHLSFLEKDLRDKVNSFFSTFKE
KESQDKTLSLPELEQQQEQQQEQQQEQVQMLAPLES

1. Halushka MK, Fan JB, Bentley K, Hsie L, Shen N, Weder A, Cooper R, Lipshutz R, Chakravarti A: Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis. Nat Genet. 1999 Jul;22(3):239-47. [PubMed:10391210 ]
2. Karathanasis SK, Yunis I, Zannis VI: Structure, evolution, and tissue-specific synthesis of human apolipoprotein AIV. Biochemistry. 1986 Jul 1;25(13):3962-70. [PubMed:3755616 ]
3. Karathanasis SK, Oettgen P, Haddad IA, Antonarakis SE: Structure, evolution, and polymorphisms of the human apolipoprotein A4 gene (APOA4). Proc Natl Acad Sci U S A. 1986 Nov;83(22):8457-61. [PubMed:3095836 ]
4. Elshourbagy NA, Walker DW, Paik YK, Boguski MS, Freeman M, Gordon JI, Taylor JM: Structure and expression of the human apolipoprotein A-IV gene. J Biol Chem. 1987 Jun 15;262(17):7973-81. [PubMed:3036793 ]
5. Yang CY, Gu ZW, Chong IS, Xiong WJ, Rosseneu M, Yang HX, Lee BR, Gotto AM Jr, Chan L: The primary structure of human apolipoprotein A-IV. Biochim Biophys Acta. 1989 Apr 3;1002(2):231-7. [PubMed:2930771 ]
6. Elshourbagy NA, Walker DW, Boguski MS, Gordon JI, Taylor JM: The nucleotide and derived amino acid sequence of human apolipoprotein A-IV mRNA and the close linkage of its gene to the genes of apolipoproteins A-I and C-III. J Biol Chem. 1986 Feb 15;261(5):1998-2002. [PubMed:3080432 ]
7. Gordon JI, Bisgaier CL, Sims HF, Sachdev OP, Glickman RM, Strauss AW: Biosynthesis of human preapolipoprotein A-IV. J Biol Chem. 1984 Jan 10;259(1):468-74. [PubMed:6706947 ]
8. Lohse P, Kindt MR, Rader DJ, Brewer HB Jr: Genetic polymorphism of human plasma apolipoprotein A-IV is due to nucleotide substitutions in the apolipoprotein A-IV gene. J Biol Chem. 1990 Jun 15;265(17):10061-4. [PubMed:2351649 ]
9. Lohse P, Kindt MR, Rader DJ, Brewer HB Jr: Human plasma apolipoproteins A-IV-0 and A-IV-3. Molecular basis for two rare variants of apolipoprotein A-IV-1. J Biol Chem. 1990 Jul 25;265(21):12734-9. [PubMed:1973689 ]
10. Lohse P, Kindt MR, Rader DJ, Brewer HB Jr: Three genetic variants of human plasma apolipoprotein A-IV. apoA-IV-1(Thr347----Ser), apoA-IV-0(Lys167----Glu,Gln360----His), and apoA-IV-3(Glu165----Lys). J Biol Chem. 1991 Jul 25;266(21):13513-8. [PubMed:1677358 ]
11. von Eckardstein A, Funke H, Schulte M, Erren M, Schulte H, Assmann G: Nonsynonymous polymorphic sites in the apolipoprotein (apo) A-IV gene are associated with changes in the concentration of apo B- and apo A-I-containing lipoproteins in a normal population. Am J Hum Genet. 1992 May;50(5):1115-28. [PubMed:1349197 ]
12. Tenkanen H, Koskinen P, Metso J, Baumann M, Lukka M, Kauppinen-Makelin R, Kontula K, Taskinen MR, Manttari M, Manninen V, et al.: A novel polymorphism of apolipoprotein A-IV is the result of an asparagine to serine substitution at residue 127. Biochim Biophys Acta. 1992 Jan 16;1138(1):27-33. [PubMed:1737067 ]
13. Kamboh MI, Williams ER, Law JC, Aston CE, Bunker CH, Ferrell RE, Pollitzer WS: Molecular basis of a unique African variant (A-IV 5) of human apolipoprotein A-IV and its significance in lipid metabolism. Genet Epidemiol. 1992;9(6):379-88. [PubMed:1487136 ]
14. Menzel HJ, Dieplinger H, Sandholzer C, Karadi I, Utermann G, Csaszar A: Apolipoprotein A-IV polymorphism in the Hungarian population: gene frequencies, effect on lipid levels, and sequence of two new variants. Hum Mutat. 1995;5(1):58-65. [PubMed:7728150 ]
15. Deeb SS, Nevin DN, Iwasaki L, Brunzell JD: Two novel apolipoprotein A-IV variants in individuals with familial combined hyperlipidemia and diminished levels of lipoprotein lipase activity. Hum Mutat. 1996;8(4):319-25. [PubMed:8956036 ]