Hmdb loader
HMDB Protein ID HMDBP02095
Secondary Accession Numbers
  • 7577
Name Calcitonin gene-related peptide 1
  1. Alpha-type CGRP
  2. CGRP-I
  3. Calcitonin gene-related peptide I
Gene Name CALCA
Protein Type Unknown
Biological Properties
General Function Involved in hormone activity
Specific Function CGRP induces vasodilation. It dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role. It also elevates platelet cAMP
Pathways Not Available
Reactions Not Available
GO Classification
extracellular region
hormone activity
protein binding
receptor binding
multicellular organismal process
system process
circulatory system process
vascular process in circulatory system
regulation of blood vessel size
Cellular Location
  1. Secreted
Gene Properties
Chromosome Location Not Available
Locus Not Available
Gene Sequence
>387 bp
Protein Properties
Number of Residues 128
Molecular Weight 13897.8
Theoretical pI 9.97
Pfam Domain Function
  • 1-25
Transmembrane Regions
  • None
Protein Sequence
>Calcitonin gene-related peptide 1
GenBank ID Protein 76880478
UniProtKB/Swiss-Prot ID P06881
UniProtKB/Swiss-Prot Entry Name CALCA_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_001033953.2
General References
  1. Taylor TD, Noguchi H, Totoki Y, Toyoda A, Kuroki Y, Dewar K, Lloyd C, Itoh T, Takeda T, Kim DW, She X, Barlow KF, Bloom T, Bruford E, Chang JL, Cuomo CA, Eichler E, FitzGerald MG, Jaffe DB, LaButti K, Nicol R, Park HS, Seaman C, Sougnez C, Yang X, Zimmer AR, Zody MC, Birren BW, Nusbaum C, Fujiyama A, Hattori M, Rogers J, Lander ES, Sakaki Y: Human chromosome 11 DNA sequence and analysis including novel gene identification. Nature. 2006 Mar 23;440(7083):497-500. [PubMed:16554811 ]
  2. Jonas V, Lin CR, Kawashima E, Semon D, Swanson LW, Mermod JJ, Evans RM, Rosenfeld MG: Alternative RNA processing events in human calcitonin/calcitonin gene-related peptide gene expression. Proc Natl Acad Sci U S A. 1985 Apr;82(7):1994-8. [PubMed:3872459 ]
  3. Broad PM, Symes AJ, Thakker RV, Craig RK: Structure and methylation of the human calcitonin/alpha-CGRP gene. Nucleic Acids Res. 1989 Sep 12;17(17):6999-7011. [PubMed:2571128 ]
  4. Nelkin BD, Rosenfeld KI, de Bustros A, Leong SS, Roos BA, Baylin SB: Structure and expression of a gene encoding human calcitonin and calcitonin gene related peptide. Biochem Biophys Res Commun. 1984 Sep 17;123(2):648-55. [PubMed:6148938 ]
  5. Edbrooke MR, Parker D, McVey JH, Riley JH, Sorenson GD, Pettengill OS, Craig RK: Expression of the human calcitonin/CGRP gene in lung and thyroid carcinoma. EMBO J. 1985 Mar;4(3):715-24. [PubMed:2408883 ]
  6. Steenbergh PH, Hoppener JW, Zandberg J, Van de Ven WJ, Jansz HS, Lips CJ: Calcitonin gene related peptide coding sequence is conserved in the human genome and is expressed in medullary thyroid carcinoma. J Clin Endocrinol Metab. 1984 Aug;59(2):358-60. [PubMed:6610687 ]
  7. Craig RK, Riley JH, Edbrooke MR, Broad PM, Foord SM, Al-Kazwini SJ, Holman JJ, Marshall I: Expression and function of the human calcitonin/alpha-CGRP gene in health and disease. Biochem Soc Symp. 1986;52:91-105. [PubMed:3034287 ]
  8. Morris HR, Panico M, Etienne T, Tippins J, Girgis SI, MacIntyre I: Isolation and characterization of human calcitonin gene-related peptide. Nature. 1984 Apr 19-25;308(5961):746-8. [PubMed:6609312 ]
  9. Petermann JB, Born W, Chang JY, Fischer JA: Identification in the human central nervous system, pituitary, and thyroid of a novel calcitonin gene-related peptide, and partial amino acid sequence in the spinal cord. J Biol Chem. 1987 Jan 15;262(2):542-5. [PubMed:3492492 ]
  10. Kitamura K, Kangawa K, Kawamoto M, Ichiki Y, Matsuo H, Eto T: Isolation and characterization of peptides which act on rat platelets, from a pheochromocytoma. Biochem Biophys Res Commun. 1992 May 29;185(1):134-41. [PubMed:1318039 ]
  11. Breeze AL, Harvey TS, Bazzo R, Campbell ID: Solution structure of human calcitonin gene-related peptide by 1H NMR and distance geometry with restrained molecular dynamics. Biochemistry. 1991 Jan 15;30(2):575-82. [PubMed:1988044 ]
  12. Hubbard JA, Martin SR, Chaplin LC, Bose C, Kelly SM, Price NC: Solution structures of calcitonin-gene-related-peptide analogues of calcitonin-gene-related peptide and amylin. Biochem J. 1991 May 1;275 ( Pt 3):785-8. [PubMed:2039456 ]