Hmdb loader
Identification
HMDB Protein ID HMDBP02295
Secondary Accession Numbers
  • 7780
Name Extracellular sulfatase Sulf-1
Synonyms
  1. hSulf-1
Gene Name SULF1
Protein Type Unknown
Biological Properties
General Function Involved in catalytic activity
Specific Function Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin. Diminishes HSPG (heparan sulfate proteoglycans) sulfation, inhibits signaling by heparin-dependent growth factors, diminishes proliferation, and facilitates apoptosis in response to exogenous stimulation
Pathways Not Available
Reactions Not Available
GO Classification
Component
golgi apparatus
cell part
endoplasmic reticulum
organelle
membrane-bounded organelle
intracellular membrane-bounded organelle
cell surface
Function
ion binding
cation binding
metal ion binding
hydrolase activity, acting on ester bonds
binding
catalytic activity
hydrolase activity
sulfuric ester hydrolase activity
calcium ion binding
Process
metabolic process
Cellular Location
  1. Golgi apparatus
  2. Endoplasmic reticulum
  3. Golgi stack
  4. Cell surface
Gene Properties
Chromosome Location Chromosome:8
Locus 8q13.1
SNPs SULF1
Gene Sequence
>2616 bp
ATGAAGTATTCTTGCTGTGCTCTGGTTTTGGCTGTCCTGGGCACAGAATTGCTGGGAAGC
CTCTGTTCGACTGTCAGATCCCCGAGGTTCAGAGGACGGATACAGCAGGAACGAAAAAAC
ATCCGACCCAACATTATTCTTGTGCTTACCGATGATCAAGATGTGGAGCTGGGGTCCCTG
CAAGTCATGAACAAAACGAGAAAGATTATGGAACATGGGGGGGCCACCTTCATCAATGCC
TTTGTGACTACACCCATGTGCTGCCCGTCACGGTCCTCCATGCTCACCGGGAAGTATGTG
CACAATCACAATGTCTACACCAACAACGAGAACTGCTCTTCCCCCTCGTGGCAGGCCATG
CATGAGCCTCGGACTTTTGCTGTATATCTTAACAACACTGGCTACAGAACAGCCTTTTTT
GGAAAATACCTCAATGAATATAATGGCAGCTACATCCCCCCTGGGTGGCGAGAATGGCTT
GGATTAATCAAGAATTCTCGCTTCTATAATTACACTGTTTGTCGCAATGGCATCAAAGAA
AAGCATGGATTTGATTATGCAAAGGACTACTTCACAGACTTAATCACTAACGAGAGCATT
AATTACTTCAAAATGTCTAAGAGAATGTATCCCCATAGGCCCGTTATGATGGTGATCAGC
CACGCTGCGCCCCACGGCCCCGAGGACTCAGCCCCACAGTTTTCTAAACTGTACCCCAAT
GCTTCCCAACACATAACTCCTAGTTATAACTATGCACCAAATATGGATAAACACTGGATT
ATGCAGTACACAGGACCAATGCTGCCCATCCACATGGAATTTACAAACATTCTACAGCGC
AAAAGGCTCCAGACTTTGATGTCAGTGGATGATTCTGTGGAGAGGCTGTATAACATGCTC
GTGGAGACGGGGGAGCTGGAGAATACTTACATCATTTACACCGCCGACCATGGTTACCAT
ATTGGGCAGTTTGGACTGGTCAAGGGGAAATCCATGCCATATGACTTTGATATTCGTGTG
CCTTTTTTTATTCGTGGTCCAAGTGTAGAACCAGGATCAATAGTCCCACAGATCGTTCTC
AACATTGACTTGGCCCCCACGATCCTGGATATTGCTGGGCTCGACACACCTCCTGATGTG
GACGGCAAGTCTGTCCTCAAACTTCTGGACCCAGAAAAGCCAGGTAACAGGTTTCGAACA
AACAAGAAGGCCAAAATTTGGCGTGATACATTCCTAGTGGAAAGAGGCAAATTTCTACGT
AAGAAGGAAGAATCCAGCAAGAATATCCAACAGTCAAATCACTTGCCCAAATATGAACGG
GTCAAAGAACTATGCCAGCAGGCCAGGTACCAGACAGCCTGTGAACAACCGGGGCAGAAG
TGGCAATGCATTGAGGATACATCTGGCAAGCTTCGAATTCACAAGTGTAAAGGACCCAGT
GACCTGCTCACAGTCCGGCAGAGCACGCGGAACCTCTACGCTCGCGGCTTCCATGACAAA
GACAAAGAGTGCAGTTGTAGGGAGTCTGGTTACCGTGCCAGCAGAAGCCAAAGAAAGAGT
CAACGGCAATTCTTGAGAAACCAGGGGACTCCAAAGTACAAGCCCAGATTTGTCCATACT
CGGCAGACACGTTCCTTGTCCGTCGAATTTGAAGGTGAAATATATGACATAAATCTGGAA
GAAGAAGAAGAATTGCAAGTGTTGCAACCAAGAAACATTGCTAAGCGTCATGATGAAGGC
CACAAGGGGCCAAGAGATCTCCAGGCTTCCAGTGGTGGCAACAGGGGCAGGATGCTGGCA
GATAGCAGCAACGCCGTGGGCCCACCTACCACTGTCCGAGTGACACACAAGTGTTTTATT
CTTCCCAATGACTCTATCCATTGTGAGAGAGAACTGTACCAATCGGCCAGAGCGTGGAAG
GACCATAAGGCATACATTGACAAAGAGATTGAAGCTCTGCAAGATAAAATTAAGAATTTA
AGAGAAGTGAGAGGACATCTGAAGAGAAGGAAGCCTGAGGAATGTAGCTGCAGTAAACAA
AGCTATTACAATAAAGAGAAAGGTGTAAAAAAGCAAGAGAAATTAAAGAGCCATCTTCAC
CCATTCAAGGAGGCTGCTCAGGAAGTAGATAGCAAACTGCAACTTTTCAAGGAGAACAAC
CGTAGGAGGAAGAAGGAGAGGAAGGAGAAGAGACGGCAGAGGAAGGGGGAAGAGTGCAGC
CTGCCTGGCCTCACTTGCTTCACGCATGACAACAACCACTGGCAGACAGCCCCGTTCTGG
AACCTGGGATCTTTCTGTGCTTGCACGAGTTCTAACAATAACACCTACTGGTGTTTGCGT
ACAGTTAATGAGACGCATAATTTTCTTTTCTGTGAGTTTGCTACTGGCTTTTTGGAGTAT
TTTGATATGAATACAGATCCTTATCAGCTCACAAATACAGTGCACACGGTAGAACGAGGC
ATTTTGAATCAGCTACACGTACAACTAATGGAGCTCAGAAGCTGTCAAGGATATAAGCAG
TGCAACCCAAGACCTAAGAATCTTGATGTTGGAAATAAAGATGGAGGAAGCTATGACCTA
CACAGAGGACAGTTATGGGATGGATGGGAAGGTTAA
Protein Properties
Number of Residues 871
Molecular Weight 101026.1
Theoretical pI 9.4
Pfam Domain Function
Signals
  • 1-22
Transmembrane Regions
  • None
Protein Sequence
>Extracellular sulfatase Sulf-1
MKYSCCALVLAVLGTELLGSLCSTVRSPRFRGRIQQERKNIRPNIILVLTDDQDVELGSL
QVMNKTRKIMEHGGATFINAFVTTPMCCPSRSSMLTGKYVHNHNVYTNNENCSSPSWQAM
HEPRTFAVYLNNTGYRTAFFGKYLNEYNGSYIPPGWREWLGLIKNSRFYNYTVCRNGIKE
KHGFDYAKDYFTDLITNESINYFKMSKRMYPHRPVMMVISHAAPHGPEDSAPQFSKLYPN
ASQHITPSYNYAPNMDKHWIMQYTGPMLPIHMEFTNILQRKRLQTLMSVDDSVERLYNML
VETGELENTYIIYTADHGYHIGQFGLVKGKSMPYDFDIRVPFFIRGPSVEPGSIVPQIVL
NIDLAPTILDIAGLDTPPDVDGKSVLKLLDPEKPGNRFRTNKKAKIWRDTFLVERGKFLR
KKEESSKNIQQSNHLPKYERVKELCQQARYQTACEQPGQKWQCIEDTSGKLRIHKCKGPS
DLLTVRQSTRNLYARGFHDKDKECSCRESGYRASRSQRKSQRQFLRNQGTPKYKPRFVHT
RQTRSLSVEFEGEIYDINLEEEEELQVLQPRNIAKRHDEGHKGPRDLQASSGGNRGRMLA
DSSNAVGPPTTVRVTHKCFILPNDSIHCERELYQSARAWKDHKAYIDKEIEALQDKIKNL
REVRGHLKRRKPEECSCSKQSYYNKEKGVKKQEKLKSHLHPFKEAAQEVDSKLQLFKENN
RRRKKERKEKRRQRKGEECSLPGLTCFTHDNNHWQTAPFWNLGSFCACTSSNNNTYWCLR
TVNETHNFLFCEFATGFLEYFDMNTDPYQLTNTVHTVERGILNQLHVQLMELRSCQGYKQ
CNPRPKNLDVGNKDGGSYDLHRGQLWDGWEG
GenBank ID Protein 189571638
UniProtKB/Swiss-Prot ID Q8IWU6
UniProtKB/Swiss-Prot Entry Name SULF1_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_001128204.1
GeneCard ID SULF1
GenAtlas ID SULF1
HGNC ID HGNC:20391
References
General References
  1. Chen R, Jiang X, Sun D, Han G, Wang F, Ye M, Wang L, Zou H: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. J Proteome Res. 2009 Feb;8(2):651-61. doi: 10.1021/pr8008012. [PubMed:19159218 ]
  2. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [PubMed:14702039 ]
  3. Kikuno R, Nagase T, Ishikawa K, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O: Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. DNA Res. 1999 Jun 30;6(3):197-205. [PubMed:10470851 ]
  4. Morimoto-Tomita M, Uchimura K, Werb Z, Hemmerich S, Rosen SD: Cloning and characterization of two extracellular heparin-degrading endosulfatases in mice and humans. J Biol Chem. 2002 Dec 20;277(51):49175-85. Epub 2002 Oct 3. [PubMed:12368295 ]
  5. Lai J, Chien J, Staub J, Avula R, Greene EL, Matthews TA, Smith DI, Kaufmann SH, Roberts LR, Shridhar V: Loss of HSulf-1 up-regulates heparin-binding growth factor signaling in cancer. J Biol Chem. 2003 Jun 20;278(25):23107-17. Epub 2003 Apr 9. [PubMed:12686563 ]