Hmdb loader
Identification
HMDB Protein ID HMDBP02314
Secondary Accession Numbers
  • 7799
Name Feline leukemia virus subgroup C receptor-related protein 1
Synonyms
  1. Feline leukemia virus subgroup C receptor
  2. hFLVCR
Gene Name FLVCR1
Protein Type Unknown
Biological Properties
General Function Involved in transmembrane transport
Specific Function Exports cytoplasmic heme. May be required to protect developing erythroid cells from heme toxicity. Causes susceptibility to FeLV-C in vitro
Pathways Not Available
Reactions Not Available
GO Classification
Process
establishment of localization
transport
transmembrane transport
Cellular Location
  1. Cell membrane
  2. Multi-pass membrane protein
Gene Properties
Chromosome Location Chromosome:1
Locus 1q32.3
SNPs FLVCR1
Gene Sequence
>1668 bp
ATGGCGCGGCCAGACGATGAGGAGGGGGCGGCGGTGGCGCCCGGACACCCGCTCGCGAAA
GGATACCTCCCGTTGCCGAGGGGCGCGCCCGTTGGGAAGGAGAGCGTGGAGCTGCAGAAC
GGGCCCAAAGCGGGCACCTTCCCGGTGAATGGGGCCCCCCGGGACAGCCTCGCTGCCGCC
TCGGGAGTTCTGGGCGGGCCTCAGACTCCACTGGCCCCAGAAGAGGAGACCCAGGCCCGG
CTGCTGCCTGCGGGCGCGGGAGCTGAGACCCCGGGGGCCGAGAGCAGCCCGCTGCCCCTT
ACGGCGCTCTCCCCGCGGCGCTTCGTGGTGCTCCTGATCTTCAGCCTGTACTCGCTGGTC
AACGCCTTTCAGTGGATCCAGTACAGCATCATTAGCAACGTCTTCGAGGGCTTCTACGGT
GTCACCTTGCTGCACATCGACTGGCTGTCCATGGTGTACATGCTGGCCTACGTGCCCCTC
ATCTTCCCGGCCACCTGGCTGCTGGACACCAGAGGCCTGCGGCTCACCGCCCTGCTGGGC
TCCGGCCTCAACTGCCTGGGTGCCTGGATCAAGTGCGGCAGTGTGCAACAACATCTCTTC
TGGGTCACCATGTTGGGCCAGTGCTTGTGCTCGGTGGCCCAGGTGTTCATCCTGGGCTTG
CCCTCCCGCATCGCCTCAGTGTGGTTTGGGCCCAAAGAGGTGTCCACAGCTTGTGCCACC
GCCGTGCTGGGCAATCAGCTTGGAACTGCAGTTGGCTTTTTGCTACCACCAGTTTTAGTA
CCCAACACACAGAATGACACAAATCTCCTGGCTTGTAATATCAGCACCATGTTTTATGGA
ACATCAGCTGTTGCCACACTTTTATTTATTTTAACAGCAATTGCCTTCAAAGAAAAACCT
CGGTATCCACCAAGTCAGGCTCAAGCAGCTCTTCAAGACAGTCCCCCTGAAGAGTACTCC
TATAAGAAATCAATAAGAAACCTGTTTAAAAACATTCCTTTTGTCCTTCTGTTGATCACT
TATGGTATCATGACTGGTGCCTTTTATTCAGTCTCAACGTTATTAAATCAAATGATATTG
ACATATTATGAGGGAGAAGAAGTCAATGCTGGAAGGATTGGGCTAACGCTAGTAGTAGCT
GGAATGGTGGGCTCTATTCTTTGTGGCTTATGGCTGGATTATACTAAAACATACAAACAG
ACTACCCTGATAGTTTATATTTTGTCTTTTATTGGAATGGTTATCTTTACTTTCACATTG
GACCTTAGATATATTATCATCGTGTTTGTTACTGGAGGGGTGCTTGGCTTCTTCATGACT
GGTTACCTCCCTTTGGGTTTTGAATTTGCTGTTGAAATCACTTACCCTGAATCTGAAGGT
ACTTCATCTGGTCTTCTTAATGCTTCTGCACAGATATTTGGAATTTTGTTCACATTGGCT
CAAGGAAAGCTCACATCAGACTATGGTCCTAAGGCAGGGAACATTTTTCTCTGTGTCTGG
ATGTTTATAGGCATCATATTAACAGCATTAATCAAGTCTGATCTGCGAAGACACAACATA
AATATAGGAATTACAAATGTTGATGTTAAAGCTATACCAGCTGACAGTCCCACAGACCAA
GAACCAAAAACGGTTATGTTGTCCAAGCAGTCAGAATCAGCAATTTGA
Protein Properties
Number of Residues 555
Molecular Weight 59862.3
Theoretical pI 5.78
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • 108-128
  • 148-168
  • 175-195
  • 200-220
  • 241-261
  • 276-296
  • 332-352
  • 373-393
  • 402-422
  • 425-445
  • 460-480
  • 491-511
Protein Sequence
>Feline leukemia virus subgroup C receptor-related protein 1
MARPDDEEGAAVAPGHPLAKGYLPLPRGAPVGKESVELQNGPKAGTFPVNGAPRDSLAAA
SGVLGGPQTPLAPEEETQARLLPAGAGAETPGAESSPLPLTALSPRRFVVLLIFSLYSLV
NAFQWIQYSIISNVFEGFYGVTLLHIDWLSMVYMLAYVPLIFPATWLLDTRGLRLTALLG
SGLNCLGAWIKCGSVQQHLFWVTMLGQCLCSVAQVFILGLPSRIASVWFGPKEVSTACAT
AVLGNQLGTAVGFLLPPVLVPNTQNDTNLLACNISTMFYGTSAVATLLFILTAIAFKEKP
RYPPSQAQAALQDSPPEEYSYKKSIRNLFKNIPFVLLLITYGIMTGAFYSVSTLLNQMIL
TYYEGEEVNAGRIGLTLVVAGMVGSILCGLWLDYTKTYKQTTLIVYILSFIGMVIFTFTL
DLRYIIIVFVTGGVLGFFMTGYLPLGFEFAVEITYPESEGTSSGLLNASAQIFGILFTLA
QGKLTSDYGPKAGNIFLCVWMFIGIILTALIKSDLRRHNINIGITNVDVKAIPADSPTDQ
EPKTVMLSKQSESAI
GenBank ID Protein 5565872
UniProtKB/Swiss-Prot ID Q9Y5Y0
UniProtKB/Swiss-Prot Entry Name FLVC1_HUMAN
PDB IDs Not Available
GenBank Gene ID AF118637
GeneCard ID FLVCR1
GenAtlas ID FLVCR1
HGNC ID HGNC:24682
References
General References
  1. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [PubMed:14702039 ]
  2. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  3. Mayya V, Lundgren DH, Hwang SI, Rezaul K, Wu L, Eng JK, Rodionov V, Han DK: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. Sci Signal. 2009 Aug 18;2(84):ra46. doi: 10.1126/scisignal.2000007. [PubMed:19690332 ]
  4. Gauci S, Helbig AO, Slijper M, Krijgsveld J, Heck AJ, Mohammed S: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. Anal Chem. 2009 Jun 1;81(11):4493-501. doi: 10.1021/ac9004309. [PubMed:19413330 ]
  5. Tailor CS, Willett BJ, Kabat D: A putative cell surface receptor for anemia-inducing feline leukemia virus subgroup C is a member of a transporter superfamily. J Virol. 1999 Aug;73(8):6500-5. [PubMed:10400745 ]
  6. Lipovich L, Hughes AL, King MC, Abkowitz JL, Quigley JG: Genomic structure and evolutionary context of the human feline leukemia virus subgroup C receptor (hFLVCR) gene: evidence for block duplications and de novo gene formation within duplicons of the hFLVCR locus. Gene. 2002 Mar 20;286(2):203-13. [PubMed:11943475 ]
  7. Quigley JG, Yang Z, Worthington MT, Phillips JD, Sabo KM, Sabath DE, Berg CL, Sassa S, Wood BL, Abkowitz JL: Identification of a human heme exporter that is essential for erythropoiesis. Cell. 2004 Sep 17;118(6):757-66. [PubMed:15369674 ]