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Identification
HMDB Protein ID HMDBP02421
Secondary Accession Numbers
  • 7915
Name cAMP-responsive element modulator
Synonyms
  1. ICER
  2. Inducible cAMP early repressor
Gene Name CREM
Protein Type Unknown
Biological Properties
General Function Involved in sequence-specific DNA binding transcription factor activity
Specific Function Transcriptional regulator that binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. Isoforms are either transcriptional activators or repressors. Plays a role in spermatogenesis and is involved in spermatid maturation
Pathways Not Available
Reactions Not Available
GO Classification
Component
organelle
membrane-bounded organelle
intracellular membrane-bounded organelle
nucleus
Function
binding
protein binding
nucleic acid binding
dna binding
protein dimerization activity
sequence-specific dna binding
sequence-specific dna binding transcription factor activity
Process
biological regulation
regulation of biological process
regulation of metabolic process
regulation of macromolecule metabolic process
regulation of gene expression
regulation of transcription
regulation of transcription, dna-dependent
Cellular Location
  1. Nucleus
Gene Properties
Chromosome Location Chromosome:1
Locus 10p11.21
SNPs CREM
Gene Sequence
>1050 bp
ATGAGCAAATGTGCAAGGAAAAAATATATTAAGACAAATCCAAGACAAATGACCATGGAA
ACAGTTGAATCCCAGCATGATGGAAGTATAACAGCTTCTTTGACAGAGAGCAAGTCTGCT
CATGTGCAGACTCAGACTGGCCAAAATTCAATCCCTGCTTTAGCTCAGGTTTCTGTGGCT
GGATCAGGCACCGGAAGAGGCTCCCCAGCTGTAACTCTAGTGCAGTTACCTTCGGGCCAA
ACTATACATGTCCAGGGAGTAATTCAGACACCACAGCCATCGGTTATTCAGTCATCACAA
ATACACACCGTTCAGGTAGCAGCAATTGCAGAGACAGATGAATCTGCAGAATCAGAAGGT
GTAATTGATTCTCATAAACGTAGAGAAATCCTTTCACGAAGACCCTCTTATAGGAAAATA
CTGAATGAACTGTCCTCTGATGTGCCTGGTGTTCCCAAGATTGAAGAAGAGAGATCAGAG
GAAGAAGGAACACCACCTAGTATTGCTACCATGGCAGTACCAACTAGCATATATCAGACT
AGCACGGGGCAATACATTGCTATAGCCCAAGGTGGAACAATCCAGATTTCTAACCCAGGA
TCTGATGGTGTTCAGGGACTGCAGGCATTAACAATGACAAATTCAGGAGCTCCTCCACCA
GGTGCTACAATTGTACAGTATGCAGCACAATCAGCTGATGGCACACAGCAGTTCTTTGTC
CCAGGCAGCCAGGTTGTTGTTCCAGCTGCCACTGGTGACATGCCAACTTACCAGATCCGA
GCTCCTACTGCTGCTTTGCCACAGGGAGTGGTGATGGCTGCATCGCCCGGAAGTTTGCAC
AGTCCCCAGCAGCTGGCAGAAGAAGCAACACGCAAACGAGAGCTAAGGCTAATGAAAAAC
AGGGAAGCTGCCAAAGAATGTCGACGTCGAAAGAAAGAATATGTAAAATGTCTGGAGAGC
CGAGTTGCAGTGCTGGAAGTCCAGAACAAGAAGCTTATAGAGGAACTTGAAACCTTGAAA
GACATTTGTTCTCCCAAAACAGATTACTAG
Protein Properties
Number of Residues 361
Molecular Weight 38939.6
Theoretical pI 6.63
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • None
Protein Sequence
>cAMP-responsive element modulator
MSKCARKKYIKTNPRQMTMETVESQHDGSITASLTESKSAHVQTQTGQNSIPALAQVSVA
GSGTRRGSPAVTLVQLPSGQTIHVQGVIQTPQPWVIQSSEIHTVQVAAIAETDESAESEG
VIDSHKRREILSRRPSYRKILNELSSDVPGVPKIEEERSEEEGTPPSIATMAVPTSIYQT
STGQYIAIAQGGTIQISNPGSDGVQGLQALTMTNSGAPPPGATIVQYAAQSADGTQQFFV
PGSQVVVQDEETELAPSHMAAATGDMPTYQIRAPTAALPQGVVMAASPGSLHSPQQLAEE
ATRKRELRLMKNREAAKECRRRKKEYVKCLESRVAVLEVQNKKLIEELETLKDICSPKTD
Y
GenBank ID Protein 114630088
UniProtKB/Swiss-Prot ID Q03060
UniProtKB/Swiss-Prot Entry Name CREM_HUMAN
PDB IDs Not Available
GenBank Gene ID XM_001148291
GeneCard ID CREM
GenAtlas ID CREM
HGNC ID HGNC:2352
References
General References
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  7. Fujimoto T, Fujisawa J, Yoshida M: Novel isoforms of human cyclic AMP-responsive element modulator (hCREM) mRNA. J Biochem. 1994 Feb;115(2):298-303. [PubMed:8206879 ]
  8. Bodor J, Spetz AL, Strominger JL, Habener JF: cAMP inducibility of transcriptional repressor ICER in developing and mature human T lymphocytes. Proc Natl Acad Sci U S A. 1996 Apr 16;93(8):3536-41. [PubMed:8622971 ]
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  11. Meyer TE, Habener JF: Cyclic AMP response element binding protein CREB and modulator protein CREM are products of distinct genes. Nucleic Acids Res. 1992 Nov 25;20(22):6106. [PubMed:1461747 ]
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