| Identification |
|---|
| HMDB Protein ID
| HMDBP02517 |
| Secondary Accession Numbers
| |
| Name
| Arylsulfatase H |
| Synonyms
|
- ASH
|
| Gene Name
| ARSH |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Involved in catalytic activity |
| Specific Function
| Not Available |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
| Function |
| hydrolase activity, acting on ester bonds |
| catalytic activity |
| hydrolase activity |
| sulfuric ester hydrolase activity |
| Process |
| metabolic process |
|
| Cellular Location
|
- Membrane
- Multi-pass membrane protein (Potential)
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| ARSH |
| Gene Sequence
|
>1689 bp
ATGACAAGAAACGCCAGACCCAACATTGTCCTGCTGATGGCAGATGACCTTGGAGTGGGG
GATTTGTGCTGCTACGGTAATAACTCAGTGAGCACACCTAATATTGACCGCCTGGCAAGT
GAAGGAGTGAGGCTTACCCAGCATCTCGCAGCTGCTTCCATGTGCACCCCAAGTCGGGCT
GCCTTCCTGACCGGCCGGTACCCCATCAGATCAGGGATGGTGTCTGCCTACAACCTGAAC
CGTGCCTTCACGTGGCTTGGTGGGTCAGGTGGTCTTCCCACCAATGAAACGACTTTTGCC
AAGCTGCTGCAGCACCGTGGCTACCGCACGGGACTCATAGGCAAATGGCACCTGGGTTTG
AGCTGCGCCTCTCGGAATGATCACTGTTACCACCCGCTCAACCATGGTTTTCACTACTTT
TACGGGGTGCCTTTTGGACTTTTAAGCGACTGCCAGGCATCCAAGACACCAGAACTGCAC
CGCTGGCTCAGGATCAAACTGTGGATCTCCACGGTAGCCCTTGCCCTGGTTCCTTTTCTG
CTTCTCATTCCCAAGTTCGCCCGCTGGTTCTCAGTGCCATGGAAGGTCATCTTTGTCTTT
GCTCTCCTCGCCTTTCTGTTTTTCACTTCCTGGTACTCTAGTTATGGATTTACTCGACGT
TGGAATTGCATCCTTATGAGGAACCATGAAATTATCCAGCAGCCAATGAAAGAGGAGAAA
GTAGCTTCCCTCATGCTGAAGGAGGCACTTGCTTTCATTGAAAGGTACAAAAGGGAACCT
TTTCTCCTCTTTTTTTCCTTCCTGCACGTACATACTCCACTCATCTCCAAAAAGAAGTTT
GTTGGGCGCAGTAAATATGGCAGGTATGGGGACAATGTAGAAGAAATGGATTGGATGGTG
GGTAAAATCCTGGATGCCCTGGACCAGGAGCGCCTGGCCAACCACACCTTGGTGTACTTC
ACCTCTGACAACGGGGGCCACCTGGAGCCCCTGGACGGGGCTGTTCAGCTGGGTGGCTGG
AACGGGATCTACAAAGGTGGCAAAGGAATGGGAGGATGGGAAGGAGGTATCCGTGTGCCA
GGGATATTCCGGTGGCCGTCAGTCTTGGAGGCTGGGAGAGTGATCAATGAGCCCACCAGC
TTAATGGACATCTATCCGACGCTGTCTTATATAGGCGGAGGGATCTTGTCCCAGGACAGA
GTGATTGACGGCCAGAACCTAATGCCCCTGCTGGAAGGAAGGGCGTCCCACTCCGACCAC
GAGTTCCTCTTCCACTACTGTGGGGTCTATCTGCACACGGTCAGGTGGCATCAGAAGGAC
TGTGCAACTGTGTGGAAAGCTCATTATGTGACTCCTAAATTCTACCCTGAAGGAACAGGT
GCCTGCTATGGGAGTGGAATATGTTCATGTTCGGGGGATGTAACCTACCACGACCCACCA
CTCCTCTTTGACATCTCAAGAGACCCTTCAGAAGCCCTTCCACTGAACCCTGACAATGAG
CCATTATTTGACTCCGTGATCAAAAAGATGGAGGCAGCCATAAGAGAGCATCGTAGGACA
CTAACACCTGTCCCACAGCAGTTCTCTGTGTTCAACACAATTTGGAAACCATGGCTGCAG
CCTTGCTGTGGGACCTTCCCCTTCTGTGGGTGTGACAAGGAAGATGACATCCTTCCCATG
GCTCCCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 562 |
| Molecular Weight
| 63524.7 |
| Theoretical pI
| 8.24 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Arylsulfatase H
MTRNARPNIVLLMADDLGVGDLCCYGNNSVSTPNIDRLASEGVRLTQHLAAASMCTPSRA
AFLTGRYPIRSGMVSAYNLNRAFTWLGGSGGLPTNETTFAKLLQHRGYRTGLIGKWHLGL
SCASRNDHCYHPLNHGFHYFYGVPFGLLSDCQASKTPELHRWLRIKLWISTVALALVPFL
LLIPKFARWFSVPWKVIFVFALLAFLFFTSWYSSYGFTRRWNCILMRNHEIIQQPMKEEK
VASLMLKEALAFIERYKREPFLLFFSFLHVHTPLISKKKFVGRSKYGRYGDNVEEMDWMV
GKILDALDQERLANHTLVYFTSDNGGHLEPLDGAVQLGGWNGIYKGGKGMGGWEGGIRVP
GIFRWPSVLEAGRVINEPTSLMDIYPTLSYIGGGILSQDRVIDGQNLMPLLEGRASHSDH
EFLFHYCGVYLHTVRWHQKDCATVWKAHYVTPKFYPEGTGACYGSGICSCSGDVTYHDPP
LLFDISRDPSEALPLNPDNEPLFDSVIKKMEAAIREHRRTLTPVPQQFSVFNTIWKPWLQ
PCCGTFPFCGCDKEDDILPMAP
|
| External Links |
|---|
| GenBank ID Protein
| 58201090 |
| UniProtKB/Swiss-Prot ID
| Q5FYA8 |
| UniProtKB/Swiss-Prot Entry Name
| ARSH_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AY875940 |
| GeneCard ID
| ARSH |
| GenAtlas ID
| ARSH |
| HGNC ID
| HGNC:32488 |
| References |
|---|
| General References
| - Sardiello M, Annunziata I, Roma G, Ballabio A: Sulfatases and sulfatase modifying factors: an exclusive and promiscuous relationship. Hum Mol Genet. 2005 Nov 1;14(21):3203-17. Epub 2005 Sep 20. [PubMed:16174644 ]
|
