| Identification |
|---|
| HMDB Protein ID
| HMDBP02736 |
| Secondary Accession Numbers
| |
| Name
| Keratinocyte growth factor |
| Synonyms
|
- FGF-7
- Fibroblast growth factor 7
- HBGF-7
- Heparin-binding growth factor 7
- KGF
|
| Gene Name
| FGF7 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in growth factor activity |
| Specific Function
| Growth factor active on keratinocytes. Possible major paracrine effector of normal epithelial cell proliferation |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
| Function |
| binding |
| protein binding |
| receptor binding |
| growth factor activity |
|
| Cellular Location
|
- Secreted
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 15q21.2 |
| SNPs
| FGF7 |
| Gene Sequence
|
>585 bp
ATGCACAAATGGATACTGACATGGATCCTGCCAACTTTGCTCTACAGATCATGCTTTCAC
ATTATCTGTCTAGTGGGTACTATATCTTTAGCTTGCAATGACATGACTCCAGAGCAAATG
GCTACAAATGTGAACTGTTCCAGCCCTGAGCGACACACAAGAAGTTATGATTACATGGAA
GGAGGGGATATAAGAGTGAGAAGACTCTTCTGTCGAACACAGTGGTACCTGAGGATCGAT
AAAAGAGGCAAAGTAAAAGGGACCCAAGAGATGAAGAATAATTACAATATCATGGAAATC
AGGACAGTGGCAGTTGGAATTGTGGCAATCAAAGGGGTGGAAAGTGAATTCTATCTTGCA
ATGAACAAGGAAGGAAAACTCTATGCAAAGAAAGAATGCAATGAAGATTGTAACTTCAAA
GAACTAATTCTGGAAAACCATTACAACACATATGCATCAGCTAAATGGACACACAACGGA
GGGGAAATGTTTGTTGCCTTAAATCAAAAGGGGATTCCTGTAAGAGGAAAAAAAACGAAG
AAAGAACAAAAAACAGCCCACTTTCTTCCTATGGCAATAACTTAA
|
| Protein Properties |
|---|
| Number of Residues
| 194 |
| Molecular Weight
| 22509.1 |
| Theoretical pI
| 9.51 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Keratinocyte growth factor
MHKWILTWILPTLLYRSCFHIICLVGTISLACNDMTPEQMATNVNCSSPERHTRSYDYME
GGDIRVRRLFCRTQWYLRIDKRGKVKGTQEMKNNYNIMEIRTVAVGIVAIKGVESEFYLA
MNKEGKLYAKKECNEDCNFKELILENHYNTYASAKWTHNGGEMFVALNQKGIPVRGKKTK
KEQKTAHFLPMAIT
|
| External Links |
|---|
| GenBank ID Protein
| 186739 |
| UniProtKB/Swiss-Prot ID
| P21781 |
| UniProtKB/Swiss-Prot Entry Name
| FGF7_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| M60828 |
| GeneCard ID
| FGF7 |
| GenAtlas ID
| FGF7 |
| HGNC ID
| HGNC:3685 |
| References |
|---|
| General References
| - Finch PW, Rubin JS, Miki T, Ron D, Aaronson SA: Human KGF is FGF-related with properties of a paracrine effector of epithelial cell growth. Science. 1989 Aug 18;245(4919):752-5. [PubMed:2475908 ]
- Aaronson SA, Bottaro DP, Miki T, Ron D, Finch PW, Fleming TP, Ahn J, Taylor WG, Rubin JS: Keratinocyte growth factor. A fibroblast growth factor family member with unusual target cell specificity. Ann N Y Acad Sci. 1991;638:62-77. [PubMed:1664700 ]
- Rubin JS, Osada H, Finch PW, Taylor WG, Rudikoff S, Aaronson SA: Purification and characterization of a newly identified growth factor specific for epithelial cells. Proc Natl Acad Sci U S A. 1989 Feb;86(3):802-6. [PubMed:2915979 ]
- Beer HD, Bittner M, Niklaus G, Munding C, Max N, Goppelt A, Werner S: The fibroblast growth factor binding protein is a novel interaction partner of FGF-7, FGF-10 and FGF-22 and regulates FGF activity: implications for epithelial repair. Oncogene. 2005 Aug 11;24(34):5269-77. [PubMed:15806171 ]
|
