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Showing Protein Long-chain fatty acid transport protein 6 (HMDBP02868)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 9 metabolites
Identification
HMDB Protein ID HMDBP02868
Secondary Accession Numbers
  • 8375
Name Long-chain fatty acid transport protein 6
Synonyms
  1. FATP-6
  2. Fatty acid transport protein 6
  3. Fatty-acid-coenzyme A ligase, very long-chain 2
  4. Solute carrier family 27 member 6
  5. VLCSH1
  6. Very long-chain acyl-CoA synthetase homolog 1
  7. hVLCS-H1
Gene Name SLC27A6
Protein Type Enzyme
Biological Properties
General Function Involved in catalytic activity
Specific Function Involved in translocation of long-chain fatty acids (LFCA) across the plasma membrane. Thought to function as the predominant fatty acid protein transporter in heart
Pathways Not Available
Reactions Not Available
GO Classification
Function
catalytic activity
Process
metabolic process
Cellular Location
  1. Cell membrane
  2. Membrane
  3. Multi-pass membrane protein (Potential)
  4. sarcolemma
Gene Properties
Chromosome Location Chromosome:5
Locus 5q23.3
SNPs SLC27A6
Gene Sequence 
>1860 bp
ATGCTGCTGTCATGGCTAACAGTTCTAGGGGCTGGAATGGTCGTCCTGCACTTCTTGCAG
AAACTCCTGTTCCCTTACTTTTGGGATGACTTCTGGTTCGTGTTGAAGGTGGTGCTCATT
ATAATTCGGCTGAAGAAGTATGAAAAGAGAGGGGAGCTGGTGACTGTGCTGGATAAATTC
TTGAGTCATGCCAAAAGACAACCTCGGAAACCTTTCATCATCTATGAGGGAGACATCTAC
ACCTATCAGGATGTAGACAAAAGGAGCAGCAGAGTGGCCCATGTCTTCCTGAACCATTCC
TCTCTGAAAAAGGGGGACACGGTGGCTCTGCTGATGAGCAATGAGCCGGACTTCGTTCAC
GTGTGGTTCGGCCTCGCCAAGCTGGGCTGCGTGGTGGCCTTTCTCAACACCAACATTCGC
TCCAACTCCCTCCTGAATTGCATCCGCGCCTGTGGGCCCAGAGCCCTAGTGGTGGGCGCA
GATTTGCTTGGAACGGTAGAAGAAATCCTTCCAAGCCTCTCAGAAAATATCAGTGTTTGG
GGGATGAAAGATTCTGTTCCACAAGGTGTAATTTCACTCAAAGAAAAACTGAGCACCTCA
CCTGATGAGCCCGTGCCACGCAGCCACCATGTTGTCTCACTCCTCAAGTCTACTTGTCTT
TACATTTTTACCTCTGGAACAACAGGTCTACCAAAAGCAGCTGTGATTAGTCAGCTGCAG
GTTTTAAGGGGTTCTGCTGTCCTGTGGGCTTTTGGTTGTACTGCTCATGACATTGTTTAT
ATAACCCTTCCTCTGTATCATAGTTCAGCAGCTATCCTGGGAATTTCTGGATGTGTTGAG
TTGGGTGCCACTTGTGTGTTAAAGAAGAAATTTTCAGCAAGCCAGTTTTGGAGTGACTGC
AAGAAGTATGATGTGACTGTGTTTCAGTATATTGGAGAACTTTGTCGCTACCTTTGCAAA
CAATCTAAGAGAGAAGGAGAAAAGGATCATAAGGTGCGTTTGGCAATTGGAAATGGCATA
CGGAGTGATGTATGGAGAGAATTTTTAGACAGATTTGGAAATATAAAGGTGTGTGAACTT
TATGCAGCTACCGAATCAAGCATATCTTTCATGAACTACACTGGGAGAATTGGAGCAATT
GGGAGAACAAATTTGTTTTACAAACTTCTTTCCACTTTTGACTTAATAAAGTATGACTTT
CAGAAAGATGAACCCATGAGAAATGAGCAGGGTTGGTGTATTCATGTGAAAAAAGGAGAA
CCTGGACTTCTCATTTCTCGAGTGAATGCAAAAAATCCCTTCTTTGGCTATGCTGGGCCT
TATAAGCACACAAAAGACAAATTGCTTTGTGATGTTTTTAAGAAGGGAGATGTTTACCTT
AATACTGGAGACTTAATAGTCCAGGATCAGGACAATTTCCTTTATTTTTGGGACCGTACT
GGAGACACTTTCAGATGGAAAGGAGAAAATGTCGCAACCACTGAGGTTGCTGATGTTATT
GGAATGTTGGATTTCATACAGGAAGCAAACGTCTATGGTGTGGCTATATCAGGTTATGAA
GGAAGAGCAGGAATGGCTTCTATTATTTTAAAACCAAATACATCTTTAGATTTGGAAAAA
GTTTATGAACAAGTTGTAACATTTCTACCAGCTTATGCTTGTCCACGATTTTTAAGAATT
CAGGAAAAAATGGAAGCAACAGGAACATTCAAACTATTGAAGCATCAGTTGGTGGAAGAT
GGATTTAATCCACTGAAAATTTCTGAACCACTTTACTTCATGGATAACTTGAAAAAGTCT
TATGTTCTACTGACCAGGGAACTTTATGATCAAATAATGTTAGGGGAAATAAAACTTTAA
Protein Properties
Number of Residues 619
Molecular Weight 70111.0
Theoretical pI 8.66
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • 22-42
  • 119-139
Protein Sequence 
>Long-chain fatty acid transport protein 6
MLLSWLTVLGAGMVVLHFLQKLLFPYFWDDFWFVLKVVLIIIRLKKYEKRGELVTVLDKF
LSHAKRQPRKPFIIYEGDIYTYQDVDKRSSRVAHVFLNHSSLKKGDTVALLMSNEPDFVH
VWFGLAKLGCVVAFLNTNIRSNSLLNCIRACGPRALVVGADLLGTVEEILPSLSENISVW
GMKDSVPQGVISLKEKLSTSPDEPVPRSHHVVSLLKSTCLYIFTSGTTGLPKAAVISQLQ
VLRGSAVLWAFGCTAHDIVYITLPLYHSSAAILGISGCVELGATCVLKKKFSASQFWSDC
KKYDVTVFQYIGELCRYLCKQSKREGEKDHKVRLAIGNGIRSDVWREFLDRFGNIKVCEL
YAATESSISFMNYTGRIGAIGRTNLFYKLLSTFDLIKYDFQKDEPMRNEQGWCIHVKKGE
PGLLISRVNAKNPFFGYAGPYKHTKDKLLCDVFKKGDVYLNTGDLIVQDQDNFLYFWDRT
GDTFRWKGENVATTEVADVIGMLDFIQEANVYGVAISGYEGRAGMASIILKPNTSLDLEK
VYEQVVTFLPAYACPRFLRIQEKMEATGTFKLLKHQLVEDGFNPLKISEPLYFMDNLKKS
YVLLTRELYDQIMLGEIKL
GenBank ID Protein 4768275
UniProtKB/Swiss-Prot ID Q9Y2P4
UniProtKB/Swiss-Prot Entry Name S27A6_HUMAN
PDB IDs Not Available
GenBank Gene ID AF064254
GeneCard ID SLC27A6
GenAtlas ID SLC27A6
HGNC ID HGNC:11000
References
General References
  1. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  2. Bechtel S, Rosenfelder H, Duda A, Schmidt CP, Ernst U, Wellenreuther R, Mehrle A, Schuster C, Bahr A, Blocker H, Heubner D, Hoerlein A, Michel G, Wedler H, Kohrer K, Ottenwalder B, Poustka A, Wiemann S, Schupp I: The full-ORF clone resource of the German cDNA Consortium. BMC Genomics. 2007 Oct 31;8:399. [PubMed:17974005 ]
  3. Gimeno RE, Ortegon AM, Patel S, Punreddy S, Ge P, Sun Y, Lodish HF, Stahl A: Characterization of a heart-specific fatty acid transport protein. J Biol Chem. 2003 May 2;278(18):16039-44. Epub 2003 Jan 28. [PubMed:12556534 ]