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Identification
HMDB Protein ID HMDBP02907
Secondary Accession Numbers
  • 8415
Name Urea transporter 1
Synonyms
  1. Solute carrier family 14 member 1
  2. Urea transporter, erythrocyte
Gene Name SLC14A1
Protein Type Transporter
Biological Properties
General Function Involved in urea transmembrane transporter activity
Specific Function Specialized low-affinity urea transporter. Mediates urea transport in erythrocytes.
Pathways Not Available
Reactions Not Available
GO Classification
Biological Process
ammonium transmembrane transport
Cellular Component
integral to plasma membrane
Component
cell part
membrane part
intrinsic to membrane
integral to membrane
Function
urea transmembrane transporter activity
transmembrane transporter activity
substrate-specific transmembrane transporter activity
transporter activity
amide transmembrane transporter activity
Molecular Function
urea transmembrane transporter activity
water transmembrane transporter activity
ammonium transmembrane transporter activity
Process
amide transport
urea transport
establishment of localization
transport
Cellular Location
  1. Membrane
  2. Multi-pass membrane protein
Gene Properties
Chromosome Location 18
Locus 18q11-q12
SNPs SLC14A1
Gene Sequence
>1170 bp
ATGGAGGACAGCCCCACTATGGTTAGAGTGGACAGCCCCACTATGGTTAGGGGTGAAAAC
CAGGTTTCGCCATGTCAAGGGAGAAGGTGCTTCCCCAAAGCTCTTGGCTATGTCACCGGT
GACATGAAAAAACTTGCCAACCAGCTTAAAGACAAACCCGTGGTGCTCCAGTTCATTGAC
TGGATTCTCCGGGGCATATCCCAAGTGGTGTTCGTCAACAACCCCGTCAGTGGAATCCTG
ATTCTGGTAGGACTTCTTGTTCAGAACCCCTGGTGGGCTCTCACTGGCTGGCTGGGAACA
GTGGTCTCCACTCTGATGGCCCTCTTGCTCAGCCAGGACAGGTCATTAATAGCATCTGGG
CTCTATGGCTACAATGCCACCCTGGTGGGAGTACTCATGGCTGTCTTTTCGGACAAGGGA
GACTATTTCTGGTGGCTGTTACTCCCTGTATGTGCTATGTCCATGACTTGCCCAATTTTC
TCAAGTGCATTGAATTCCATGCTCAGCAAATGGGACCTCCCCGTCTTCACCCTCCCTTTC
AACATGGCGTTGTCAATGTACCTTTCAGCCACAGGACATTACAATCCGTTCTTTCCAGCC
AAACTGGTCATACCTATAACTACAGCTCCAAATATCTCCTGGTCTGACCTCAGTGCCCTG
GAGTTGTTGAAATCTATACCAGTGGGAGTTGGTCAGATCTATGGCTGTGATAATCCATGG
ACAGGGGGCATTTTCCTGGGAGCCATCCTACTCTCCTCCCCACTCATGTGCCTGCATGCT
GCCATAGGATCATTGCTGGGCATAGCAGCGGGACTCAGTCTTTCAGCCCCATTTGAGGAC
ATCTACTTTGGACTCTGGGGTTTCAACAGCTCTCTGGCCTGCATTGCAATGGGAGGAATG
TTCATGGCGCTCACCTGGCAAACCCACCTCCTGGCTCTTGGCTGTGCCCTGTTCACGGCC
TATCTTGGAGTCGGCATGGCAAACTTTATGGCTGAGGTTGGATTGCCAGCTTGTACCTGG
CCCTTCTGTTTGGCCACGCTATTGTTCCTCATCATGACCACAAAAAATTCCAACATCTAC
AAGATGCCCCTCAGTAAAGTTACTTATCCTGAAGAAAACCGCATCTTCTACCTGCAAGCC
AAGAAAAGAATGGTGGAAAGCCCTTTGTGA
Protein Properties
Number of Residues 389
Molecular Weight 48341.29
Theoretical pI 6.531
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>Urea transporter 1
MEDSPTMVRVDSPTMVRGENQVSPCQGRRCFPKALGYVTGDMKELANQLKDKPVVLQFID
WILRGISQVVFVNNPVSGILILVGLLVQNPWWALTGWLGTVVSTLMALLLSQDRSLIASG
LYGYNATLVGVLMAVFSDKGDYFWWLLLPVCAMSMTCPIFSSALNSMLSKWDLPVFTLPF
NMALSMYLSATGHYNPFFPAKLVIPITTAPNISWSDLSALELLKSIPVGVGQIYGCDNPW
TGGIFLGAILLSSPLMCLHAAIGSLLGIAAGLSLSAPFEDIYFGLWGFNSSLACIAMGGM
FMALTWQTHLLALGCALFTAYLGVGMANFMAEVGLPACTWPFCLATLLFLIMTTKNSNIY
KMPLSKVTYPEENRIFYLQAKKRMVESPL
GenBank ID Protein 193784782
UniProtKB/Swiss-Prot ID Q13336
UniProtKB/Swiss-Prot Entry Name UT1_HUMAN
PDB IDs Not Available
GenBank Gene ID AK123681
GeneCard ID SLC14A1
GenAtlas ID SLC14A1
HGNC ID HGNC:10918
References
General References
  1. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [PubMed:14702039 ]
  2. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  3. Olives B, Neau P, Bailly P, Hediger MA, Rousselet G, Cartron JP, Ripoche P: Cloning and functional expression of a urea transporter from human bone marrow cells. J Biol Chem. 1994 Dec 16;269(50):31649-52. [PubMed:7989337 ]
  4. Davey S, Beach D: RACH2, a novel human gene that complements a fission yeast cell cycle checkpoint mutation. Mol Biol Cell. 1995 Oct;6(10):1411-21. [PubMed:8573795 ]
  5. Olives B, Merriman M, Bailly P, Bain S, Barnett A, Todd J, Cartron JP, Merriman T: The molecular basis of the Kidd blood group polymorphism and its lack of association with type 1 diabetes susceptibility. Hum Mol Genet. 1997 Jul;6(7):1017-20. [PubMed:9215669 ]
  6. Sidoux-Walter F, Lucien N, Olives B, Gobin R, Rousselet G, Kamsteeg EJ, Ripoche P, Deen PM, Cartron JP, Bailly P: At physiological expression levels the Kidd blood group/urea transporter protein is not a water channel. J Biol Chem. 1999 Oct 15;274(42):30228-35. [PubMed:10514515 ]
  7. Sidoux-Walter F, Lucien N, Nissinen R, Sistonen P, Henry S, Moulds J, Cartron JP, Bailly P: Molecular heterogeneity of the Jk(null) phenotype: expression analysis of the Jk(S291P) mutation found in Finns. Blood. 2000 Aug 15;96(4):1566-73. [PubMed:10942407 ]
  8. Irshaid NM, Henry SM, Olsson ML: Genomic characterization of the kidd blood group gene:different molecular basis of the Jk(a-b-) phenotype in Polynesians and Finns. Transfusion. 2000 Jan;40(1):69-74. [PubMed:10644814 ]