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Identification
HMDB Protein ID HMDBP02990
Secondary Accession Numbers
  • 8510
Name Peroxiredoxin-1
Synonyms
  1. NKEF-A
  2. Natural killer cell-enhancing factor A
  3. PAG
  4. Proliferation-associated gene protein
  5. Thioredoxin peroxidase 2
  6. Thioredoxin-dependent peroxide reductase 2
Gene Name PRDX1
Protein Type Enzyme
Biological Properties
General Function Involved in antioxidant activity
Specific Function Involved in redox regulation of the cell. Reduces peroxides with reducing equivalents provided through the thioredoxin system but not from glutaredoxin. May play an important role in eliminating peroxides generated during metabolism. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2). Reduces an intramolecular disulfide bond in GDPD5 that gates the ability to GDPD5 to drive postmitotic motor neuron differentiation (By similarity).
Pathways
  • Peroxisome
Reactions
R'-SH + ROOH → R'-S-S-R' + Water + ROH details
GO Classification
Biological Process
natural killer cell mediated cytotoxicity
regulation of NF-kappaB import into nucleus
regulation of stress-activated MAPK cascade
cell proliferation
skeletal system development
removal of superoxide radicals
hydrogen peroxide catabolic process
erythrocyte homeostasis
Cellular Component
mitochondrion
nucleus
melanosome
Function
peroxiredoxin activity
catalytic activity
antioxidant activity
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
oxidoreductase activity
Molecular Function
thioredoxin peroxidase activity
Process
cellular process
cellular homeostasis
cell redox homeostasis
Cellular Location
  1. Cytoplasm
  2. Melanosome
Gene Properties
Chromosome Location 1
Locus 1p34.1
SNPs PRDX1
Gene Sequence
>600 bp
ATGTCTTCAGGAAATGCTAAAATTGGGCACCCTGCCCCCAACTTCAAAGCCACAGCTGTT
ATGCCAGATGGTCAGTTTAAAGATATCAGCCTGTCTGACTACAAAGGAAAATATGTTGTG
TTCTTCTTTTACCCTCTTGACTTCACCTTTGTGTGCCCCACGGAGATCATTGCTTTCAGT
GATAGGGCAGAAGAATTTAAGAAACTCAACTGCCAAGTGATTGGTGCTTCTGTGGATTCT
CACTTCTGTCATCTAGCATGGGTCAATACACCTAAGAAACAAGGAGGACTGGGACCCATG
AACATTCCTTTGGTATCAGACCCGAAGCGCACCATTGCTCAGGATTATGGGGTCTTAAAG
GCTGATGAAGGCATCTCGTTCAGGGGCCTTTTTATCATTGATGATAAGGGTATTCTTCGG
CAGATCACTGTAAATGACCTCCCTGTTGGCCGCTCTGTGGATGAGACTTTGAGACTAGTT
CAGGCCTTCCAGTTCACTGACAAACATGGGGAAGTGTGCCCAGCTGGCTGGAAACCTGGC
AGTGATACCATCAAGCCTGATGTCCAAAAGAGCAAAGAATATTTCTCCAAGCAGAAGTAA
Protein Properties
Number of Residues 199
Molecular Weight 22110.19
Theoretical pI 8.132
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>Peroxiredoxin-1
MSSGNAKIGHPAPNFKATAVMPDGQFKDISLSDYKGKYVVFFFYPLDFTFVCPTEIIAFS
DRAEEFKKLNCQVIGASVDSHFCHLAWVNTPKKQGGLGPMNIPLVSDPKRTIAQDYGVLK
ADEGISFRGLFIIDDKGILRQITVNDLPVGRSVDETLRLVQAFQFTDKHGEVCPAGWKPG
SDTIKPDVQKSKEYFSKQK
GenBank ID Protein 197692225
UniProtKB/Swiss-Prot ID Q06830
UniProtKB/Swiss-Prot Entry Name PRDX1_HUMAN
PDB IDs
GenBank Gene ID AB451262
GeneCard ID PRDX1
GenAtlas ID PRDX1
HGNC ID HGNC:9352
References
General References
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