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Identification
HMDB Protein ID HMDBP03049
Secondary Accession Numbers
  • 8578
Name Cholesterol 25-hydroxylase
Synonyms
  1. Cholesterol 25-monooxygenase
  2. h25OH
Gene Name CH25H
Protein Type Unknown
Biological Properties
General Function Involved in iron ion binding
Specific Function Catalyzes the formation of 25-hydroxycholesterol from cholesterol, leading to repress cholesterol biosynthetic enzymes. May play an important role in regulating lipid metabolism by synthesizing a corepressor that blocks sterol regulatory element binding protein (SREBP) processing. In testis, production of 25-hydroxycholesterol by macrophages may play a role in Leydig cell differentiation.
Pathways
  • 27-Hydroxylase Deficiency
  • Cerebrotendinous Xanthomatosis (CTX)
  • Congenital Bile Acid Synthesis Defect Type II
  • Congenital Bile Acid Synthesis Defect Type III
  • Familial Hypercholanemia (FHCA)
  • Primary bile acid biosynthesis
  • Primary bile acid biosynthesis
  • Zellweger Syndrome
Reactions
Cholesterol + AH(2) + Oxygen → 25-Hydroxycholesterol + A + Water details
Cholesterol + Reduced acceptor + Oxygen → 25-Hydroxycholesterol + Acceptor + Water details
GO Classification
Biological Process
bile acid biosynthetic process
cholesterol metabolic process
sterol biosynthetic process
fatty acid biosynthetic process
Cellular Component
endoplasmic reticulum membrane
cytosol
integral to membrane
Component
endoplasmic reticulum
organelle
membrane-bounded organelle
intracellular membrane-bounded organelle
Function
ion binding
cation binding
metal ion binding
binding
catalytic activity
transition metal ion binding
iron ion binding
oxidoreductase activity
Molecular Function
iron ion binding
cholesterol 25-hydroxylase activity
steroid hydroxylase activity
Process
metabolic process
cellular metabolic process
organic acid metabolic process
oxoacid metabolic process
carboxylic acid metabolic process
monocarboxylic acid metabolic process
fatty acid metabolic process
fatty acid biosynthetic process
oxidation reduction
Cellular Location
  1. Endoplasmic reticulum membrane
  2. Multi-pass membrane protein
Gene Properties
Chromosome Location 10
Locus 10q23
SNPs CH25H
Gene Sequence
>819 bp
ATGAGCTGCCACAACTGCTCCGACCCCCAGGTCCTTTGCAGCTCCGGGCAGCTGTTCCTG
CAGCCCCTCTGGGACCACCTGAGGAGCTGGGAGGCCCTCCTACAGTCGCCCTTCTTCCCG
GTCATCTTCTCCATCACCACATACGTGGGCTTTTGCCTGCCCTTCGTGGTCCTGGATATC
CTGTGCTCCTGGGTGCCCGCCCTGCGGCGCTACAAGATCCACCCTGACTTCTCGCCATCC
GCGCAGCAGCTGCTACCTTGCCTGGGGCAGACCCTCTACCAGCATGTGATGTTTGTGTTC
CCCGTGACGCTGCTGCATTGGGCCCGCAGCCCGGCCCTCCTGCCCCACGAAGCTCCCGAG
CTGCTCCTGCTGCTGCACCACATCCTGTTCTGCCTGCTACTCTTCGACATGGAGTTCTTC
GTGTGGCACCTGCTGCACCACAAGGTGCCCTGGCTGTACCGCACCTTCCACAAGGTGCAC
CACCAGAACTCGTCCTCGTTCGCGCTGGCAACGCAGTATATGAGCGTCTGGGAACTGTTT
TCTTTGGGCTTCTTCGACATGATGAACGTCACACTGCTCGGGTGCCACCCGCTCACCACC
CTGACCTTCCACGTGGTCAACATCTGGCTTTCCGTGGAGGACCACTCCGGCTACAACTTC
CCTTGGTCCACTCACAGACTGGTGCCCTTCGGGTGGTACGGGGGTGTGGTGCACCACGAC
CTGCATCACTCTCACTTTAACTGCAACTTCGCTCCGTACTTTACACACTGGGACAAAATA
CTGGGAACGCTGCGGACTGCATCTGTCCCAGCGCGGTGA
Protein Properties
Number of Residues 272
Molecular Weight 31744.755
Theoretical pI 7.249
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>Cholesterol 25-hydroxylase
MSCHNCSDPQVLCSSGQLFLQPLWDHLRSWEALLQSPFFPVIFSITTYVGFCLPFVVLDI
LCSWVPALRRYKIHPDFSPSAQQLLPCLGQTLYQHVMFVFPVTLLHWARSPALLPHEAPE
LLLLLHHILFCLLLFDMEFFVWHLLHHKVPWLYRTFHKVHHQNSSSFALATQYMSVWELF
SLGFFDMMNVTLLGCHPLTTLTFHVVNIWLSVEDHSGYNFPWSTHRLVPFGWYGGVVHHD
LHHSHFNCNFAPYFTHWDKILGTLRTASVPAR
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID O95992
UniProtKB/Swiss-Prot Entry Name CH25H_HUMAN
PDB IDs Not Available
GenBank Gene ID AF059214
GeneCard ID CH25H
GenAtlas ID CH25H
HGNC ID HGNC:1907
References
General References
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