Hmdb loader
Identification
HMDB Protein ID HMDBP03117
Secondary Accession Numbers
  • 8659
Name Phosphate carrier protein, mitochondrial
Synonyms
  1. PTP
  2. Phosphate transport protein
  3. Solute carrier family 25 member 3
Gene Name SLC25A3
Protein Type Enzyme
Biological Properties
General Function Involved in binding
Specific Function Transport of phosphate groups from the cytosol to the mitochondrial matrix. Phosphate is cotransported with H(+). May play a role regulation of the mitochondrial permeability transition pore (mPTP).
Pathways Not Available
Reactions Not Available
GO Classification
Biological Process
generation of precursor metabolites and energy
Cellular Component
mitochondrial inner membrane
integral to plasma membrane
Component
membrane
cell part
Function
binding
Molecular Function
phosphate ion carrier activity
symporter activity
Process
establishment of localization
transport
transmembrane transport
Cellular Location
  1. Mitochondrion inner membrane
  2. Multi-pass membrane protein
Gene Properties
Chromosome Location 12
Locus 12q23
SNPs SLC25A3
Gene Sequence
>1089 bp
ATGTTCTCGTCCGTGGCGCACCTGGCGCGGGCGAACCCCTTCAACACGCCACATCTGCAG
CTGGTGCACGATGGTCTCGGGGACCTCCGCAGCAGCTCCCCAGGGCCCACGGGCCAGCCC
CGCCGCCCTCGCAACCTGGCAGCCGCCGCCGTGGAAGAGCAGTATAGCTGTGACTATGGA
TCTGGCAGATTCTTTATCCTTTGTGGACTTGGAGGAATTATTAGCTGTGGCACAACACAT
ACAGCATTGGTTCCTCTAGATCTGGTTAAATGCAGAATGCAGGTGGACCCCCAAAAGTAC
AAGGGCATATTTAACGGATTCTCAGTTACACTTAAAGAGGATGGTGTTCGTGGTTTGGCT
AAAGGATGGGCTCCGACTTTCCTTGGCTACTCCATGCAGGGACTCTGCAAGTTTGGCTTT
TATGAAGTCTTTAAAGTCTTGTATAGCAATATGCTTGGAGAGGAGAATACTTATCTCTGG
CGCACATCACTATATTTGGCTGCCTCTGCCAGTGCTGAATTCTTTGCTGACATTGCCCTG
GCTCCTATGGAAGCTGCTAAGGTTCGAATTCAAACCCAGCCAGGTTATGCCAACACTTTG
AGGGATGCAGCTCCCAAAATGTATAAGGAAGAAGGCCTAAAAGCATTCTACAAGGGGGTT
GCTCCTCTCTGGATGAGACAGATACCATACACCATGATGAAGTTCGCCTGCTTTGAACGT
ACTGTTGAAGCACTGTACAAGTTTGTGGTTCCTAAGCCCCGCAGTGAATGTTCAAAGCCA
GAGCAGCTGGTTGTAACATTTGTAGCAGGTTACATAGCTGGAGTCTTTTGTGCAATTGTT
TCTCACCCTGCTGATTCTGTGGTATCTGTGTTGAATAAAGAAAAAGGTAGCAGTGCTTCT
CTGGTCCTCAAGAGACTTGGATTTAAAGGTGTATGGAAGGGACTGTTTGCCCGTATCATC
ATGATTGGTACCCTGACTGCACTACAGTGGTTTATCTATGACTCCGTGAAGGTCTACTTC
AGACTTCCTCGCCCTCCTCCACCCGAGATGCCAGAGTCTCTGAAGAAGAAGCTTGGGTTA
ACTCAGTAG
Protein Properties
Number of Residues 362
Molecular Weight 39958.38
Theoretical pI 9.358
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>Phosphate carrier protein, mitochondrial
MFSSVAHLARANPFNTPHLQLVHDGLGDLRSSSPGPTGQPRRPRNLAAAAVEEQYSCDYG
SGRFFILCGLGGIISCGTTHTALVPLDLVKCRMQVDPQKYKGIFNGFSVTLKEDGVRGLA
KGWAPTFLGYSMQGLCKFGFYEVFKVLYSNMLGEENTYLWRTSLYLAASASAEFFADIAL
APMEAAKVRIQTQPGYANTLRDAAPKMYKEEGLKAFYKGVAPLWMRQIPYTMMKFACFER
TVEALYKFVVPKPRSECSKPEQLVVTFVAGYIAGVFCAIVSHPADSVVSVLNKEKGSSAS
LVLKRLGFKGVWKGLFARIIMIGTLTALQWFIYDSVKVYFRLPRPPPPEMPESLKKKLGL
TQ
GenBank ID Protein 6031192
UniProtKB/Swiss-Prot ID Q00325
UniProtKB/Swiss-Prot Entry Name MPCP_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_005888.3
GeneCard ID SLC25A3
GenAtlas ID SLC25A3
HGNC ID HGNC:10989
References
General References
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  3. Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M: Lysine acetylation targets protein complexes and co-regulates major cellular functions. Science. 2009 Aug 14;325(5942):834-40. doi: 10.1126/science.1175371. Epub 2009 Jul 16. [PubMed:19608861 ]
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  5. Dolce V, Iacobazzi V, Palmieri F, Walker JE: The sequences of human and bovine genes of the phosphate carrier from mitochondria contain evidence of alternatively spliced forms. J Biol Chem. 1994 Apr 8;269(14):10451-60. [PubMed:8144629 ]
  6. Dolce V, Fiermonte G, Messina A, Palmieri F: Nucleotide sequence of a human heart cDNA encoding the mitochondrial phosphate carrier. DNA Seq. 1991;2(2):133-5. [PubMed:1777677 ]
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