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Identification
HMDB Protein ID HMDBP03131
Secondary Accession Numbers
  • 8678
Name UDP-glucuronic acid/UDP-N-acetylgalactosamine transporter
Synonyms
  1. Solute carrier family 35 member D1
  2. UDP-GlcA/UDP-GalNAc transporter
  3. UDP-galactose transporter-related protein 7
  4. UGTrel7
Gene Name SLC35D1
Protein Type Enzyme
Biological Properties
General Function Involved in UDP-glucuronic acid transmembrane transport
Specific Function Transports both UDP-glucuronic acid (UDP-GlcA) and UDP-N-acetylgalactosamine (UDP-GalNAc) from the cytoplasm to into the endoplasmic reticulum lumen. May participate in glucuronidation and/or chondroitin sulfate biosynthesis.
Pathways Not Available
Reactions Not Available
GO Classification
Biological Process
chondroitin sulfate biosynthetic process
UDP-glucuronate biosynthetic process
xenobiotic metabolic process
carbohydrate transport
Cellular Component
integral to endoplasmic reticulum membrane
Molecular Function
UDP-glucuronic acid transmembrane transporter activity
UDP-N-acetylgalactosamine transmembrane transporter activity
Cellular Location
  1. Endoplasmic reticulum membrane
  2. Multi-pass membrane protein
Gene Properties
Chromosome Location 1
Locus 1p32-p31
SNPs SLC35D1
Gene Sequence
>1068 bp
ATGGCGGAAGTTCATAGACGTCAGCATGCTCGGGTTAAAGGAGAAGCCCCCGCGAAATCC
TCCACACTCCGAGATGAGGAGGAGCTGGGGATGGCGTCGGCCGAAACGCTGACCGTGTTT
CTGAAGCTGCTGGCCGCCGGCTTTTACGGCGTGAGCTCCTTCCTGATCGTGGTGGTGAAT
AAGAGCGTGCTCACCAATTACAGATTTCCCTCCTCACTATGTGTTGGACTTGGCCAGATG
GTGGCCACAGTGGCAGTTCTCTGGGTGGGAAAGGCGCTCAGAGTAGTCAAGTTTCCTGAC
CTTGACAGAAATGTACCTCGAAAGACGTTTCCACTACCTCTACTATATTTTGGGAACCAA
ATCACGGGACTGTTCAGCACAAAGAAACTGAACTTGCCAATGTTTACAGTTCTGAGAAGG
TTCTCCATCCTGTTTACAATGTTTGCTGAAGGAGTTTTACTCAAGAAGACTTTTTCTTGG
GGTATTAAAATGACTGTATTTGCAATGATTATTGGAGCCTTTGTAGCTGCCAGCTCTGAC
TTGGCATTTGATCTGGAAGGATATGCTTTTATTCTGATAAACGATGTCCTAACAGCAGCA
AATGGTGCATACGTAAAACAAAAATTAGATTCAAAAGAGCTGGGAAAATATGGACTGCTC
TATTACAATGCACTGTTCATGATTCTGCCCACCCTGGCCATTGCGTATTTCACAGGAGAT
GCACAAAAGGCTGTGGAGTTTGAAGGCTGGGCTGACACCCTCTTTCTTCTGCAGTTCACC
CTCTCCTGTGTGATGGGGTTTATCTTAATGTACGCCACAGTACTCTGCACGCAGTATAAT
TCTGCTCTTACAACTACAATAGTTGGCTGTATTAAGAATATATTAATAACTTATATTGGA
ATGGTCTTTGGTGGAGATTATATTTTCACGTGGACAAACTTCATTGGTTTAAATATCAGC
ATTGCTGGGAGCCTGGTATATTCCTATATCACTTTCACTGAAGAGCAGCTGAGCAAACAG
TCAGAGGCTAATAACAAGCTGGACATTAAGGGGAAAGGAGCAGTGTGA
Protein Properties
Number of Residues 355
Molecular Weight 39239.8
Theoretical pI 8.964
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>UDP-glucuronic acid/UDP-N-acetylgalactosamine transporter
MAEVHRRQHARVKGEAPAKSSTLRDEEELGMASAETLTVFLKLLAAGFYGVSSFLIVVVN
KSVLTNYRFPSSLCVGLGQMVATVAVLWVGKALRVVKFPDLDRNVPRKTFPLPLLYFGNQ
ITGLFSTKKLNLPMFTVLRRFSILFTMFAEGVLLKKTFSWGIKMTVFAMIIGAFVAASSD
LAFDLEGYAFILINDVLTAANGAYVKQKLDSKELGKYGLLYYNALFMILPTLAIAYFTGD
AQKAVEFEGWADTLFLLQFTLSCVMGFILMYATVLCTQYNSALTTTIVGCIKNILITYIG
MVFGGDYIFTWTNFIGLNISIAGSLVYSYITFTEEQLSKQSEANNKLDIKGKGAV
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID Q9NTN3
UniProtKB/Swiss-Prot Entry Name S35D1_HUMAN
PDB IDs Not Available
GenBank Gene ID AB044343
GeneCard ID SLC35D1
GenAtlas ID SLC35D1
HGNC ID HGNC:20800
References
General References
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  4. Nagase T, Seki N, Ishikawa K, Ohira M, Kawarabayasi Y, Ohara O, Tanaka A, Kotani H, Miyajima N, Nomura N: Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. DNA Res. 1996 Oct 31;3(5):321-9, 341-54. [PubMed:9039502 ]
  5. Muraoka M, Kawakita M, Ishida N: Molecular characterization of human UDP-glucuronic acid/UDP-N-acetylgalactosamine transporter, a novel nucleotide sugar transporter with dual substrate specificity. FEBS Lett. 2001 Apr 20;495(1-2):87-93. [PubMed:11322953 ]
  6. Hiraoka S, Furuichi T, Nishimura G, Shibata S, Yanagishita M, Rimoin DL, Superti-Furga A, Nikkels PG, Ogawa M, Katsuyama K, Toyoda H, Kinoshita-Toyoda A, Ishida N, Isono K, Sanai Y, Cohn DH, Koseki H, Ikegawa S: Nucleotide-sugar transporter SLC35D1 is critical to chondroitin sulfate synthesis in cartilage and skeletal development in mouse and human. Nat Med. 2007 Nov;13(11):1363-7. Epub 2007 Oct 21. [PubMed:17952091 ]