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Showing Protein Heparan-sulfate 6-O-sulfotransferase 3 (HMDBP03301)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 2 metabolites
Identification
HMDB Protein ID HMDBP03301
Secondary Accession Numbers
  • 8880
Name Heparan-sulfate 6-O-sulfotransferase 3
Synonyms
  1. HS6ST-3
Gene Name HS6ST3
Protein Type Enzyme
Biological Properties
General Function Involved in sulfotransferase activity
Specific Function 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate.
Pathways
  • Glycosaminoglycan biosynthesis - heparan sulfate / heparin
Reactions
Phosphoadenosine phosphosulfate + [heparan sulfate]-glucosamine → Adenosine 3',5'-diphosphate + [heparan sulfate]-glucosamine 6-sulfate details
GO Classification
Cellular Component
integral to membrane
Component
cell part
membrane part
intrinsic to membrane
integral to membrane
Function
catalytic activity
transferase activity
transferase activity, transferring sulfur-containing groups
sulfotransferase activity
Molecular Function
sulfotransferase activity
Process
metabolic process
primary metabolic process
carbohydrate metabolic process
carbohydrate biosynthetic process
Cellular Location
  1. Membrane
  2. Single-pass type II membrane protein (Potential)
Gene Properties
Chromosome Location 13
Locus 13q32.1
SNPs HS6ST3
Gene Sequence 
>1416 bp
ATGGATGAAAGGTTCAACAAGTGGCTGCTGACGCCGGTGCTCACTCTCCTCTTCGTGGTC
ATCATGTACCAGTACGTGTCCCCCTCCTGCACCAGCTCCTGCACCAACTTGGGGGAGCAG
CCCCGCGCGGGGGAGGCCGGCCCGCCCGCCGTCCCGGGTCCCGCCCGCCGGGCTCAGGCG
CCGCCGGAGGAGTGGGAGCGGCGGCCCCAGTTGCCCCCGCCGCCCCGGGGGCCCCCCGAG
GGACCTCGGGGGGCCSCGGCGCCGGAGGAGGAGGACGAGGAGCCCGGAGACCCCCGGGAG
GGGGAGGAAGAGGAGGAGGAAGACGAGCCGGACCCCGAGGCCCCGGAAAACGGCTCCCTG
CCCCGATTCGTGCCGCGCTTCAACTTCAGCCTGAAGGACCTGACCCGCTTCGTGGATTTC
AACATCAAAGGGCGCGACGTGATCGTGTTCCTCCACATCCAGAAGACGGGGGGCACCACT
TTCGGCCGGCACCTGGTGAAGAACATCCGGCTGGAGCAGCCTTGTAGCTGCAAAGCGGGT
CAGAAGAAGTGCACCTGCCACCGGCCTGGCAAGAAGGAGACGTGGCTCTTCTCCCGCTTC
TCCACCGGCTGGAGCTGCGGGCTGCACGCCGACTGGACGGAGCTCACCAACTGCGTGCCG
GCCATCATGGAGAAGAAGGACTGTCCCCGCAACCACAGCCACACCAGGAATTTCTATTAC
ATCACAATGTTACGGGATCCAGTGTCACGTTACCTGAGCGAGTGGAAACATGTCCAGAGA
GGGGCCACTTGGAAAACCTCTCTTCATATGTGTGATGGAAGAAGCCCCACCCCAGATGAG
CTGCCTACCTGCTACCCTGGGGATGACTGGTCTGGGGTCAGCTTGCGGGAGTTTATGGAT
TGCACCTACAACCTGGCTAACAATCGCCAGGTGCGCATGCTGGCTGACCTCAGCCTGGTG
GGCTGCTATAACTTGACTTTCATGAACGAGAGTGAAAGAAACACCATCCTGTTGCAGAGT
GCAAAGAACAACCTGAAGAACATGGCCTTCTTTGGGCTCACTGAGTTCCAGAGGAAGACA
CAGTTTCTCTTTGAGAGAACATTCAACCTCAAGTTCATCTCCCCCTTCACACAGTTCAAC
ATCACGCGGGCTTCTAACGTGGAGATCAACGAGGGTGCCCGCCAACGCATTGAGGATCTA
AACTTCCTGGACATGCAGCTTTACGAGTATGCAAAAGATCTCTTCCAGCAGCGCTACCAC
CACACCAAGCAGCTAGAGCACCAGAGGGACCGCCAGAAGCGGCGGGAGGAGCGGAGGCTG
CAGCGAGAGCACAGGGACCACCAGTGGCCCAAAGAAGATGGGGCTGCAGAAGGGACTGTC
ACCGAGGACTACAACAGCCAGGTGGTGAGATGGTGA
Protein Properties
Number of Residues 471
Molecular Weight 54843.27
Theoretical pI 6.835
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence 
>Heparan-sulfate 6-O-sulfotransferase 3
MDERFNKWLLTPVLTLLFVVIMYQYVSPSCTSSCTNFGEQPRAGEAGPPAVPGPARRAQA
PPEEWERRPQLPPPPRGPPEGPRGAAAPEEEDEEPGDPREGEEEEEEDEPDPEAPENGSL
PRFVPRFNFSLKDLTRFVDFNIKGRDVIVFLHIQKTGGTTFGRHLVKNIRLEQPCSCKAG
QKKCTCHRPGKKETWLFSRFSTGWSCGLHADWTELTNCVPAIMEKKDCPRNHSHTRNFYY
ITMLRDPVSRYLSEWKHVQRGATWKTSLHMCDGRSPTPDELPTCYPGDDWSGVSLREFMD
CTYNLANNRQVRMLADLSLVGCYNLTFMNESERNTILLQSAKNNLKNMAFFGLTEFQRKT
QFLFERTFNLKFISPFTQFNITRASNVEINEGARQRIEDLNFLDMQLYEYAKDLFQQRYH
HTKQLEHQRDRQKRREERRLQREHRDHQWPKEDGAAEGTVTEDYNSQVVRW
GenBank ID Protein 23452527
UniProtKB/Swiss-Prot ID Q8IZP7
UniProtKB/Swiss-Prot Entry Name H6ST3_HUMAN
PDB IDs Not Available
GenBank Gene ID AF539426
GeneCard ID HS6ST3
GenAtlas ID HS6ST3
HGNC ID HGNC:19134
References
General References
  1. Bechtel S, Rosenfelder H, Duda A, Schmidt CP, Ernst U, Wellenreuther R, Mehrle A, Schuster C, Bahr A, Blocker H, Heubner D, Hoerlein A, Michel G, Wedler H, Kohrer K, Ottenwalder B, Poustka A, Wiemann S, Schupp I: The full-ORF clone resource of the German cDNA Consortium. BMC Genomics. 2007 Oct 31;8:399. [PubMed:17974005 ]
  2. Dunham A, Matthews LH, Burton J, Ashurst JL, Howe KL, Ashcroft KJ, Beare DM, Burford DC, Hunt SE, Griffiths-Jones S, Jones MC, Keenan SJ, Oliver K, Scott CE, Ainscough R, Almeida JP, Ambrose KD, Andrews DT, Ashwell RI, Babbage AK, Bagguley CL, Bailey J, Bannerjee R, Barlow KF, Bates K, Beasley H, Bird CP, Bray-Allen S, Brown AJ, Brown JY, Burrill W, Carder C, Carter NP, Chapman JC, Clamp ME, Clark SY, Clarke G, Clee CM, Clegg SC, Cobley V, Collins JE, Corby N, Coville GJ, Deloukas P, Dhami P, Dunham I, Dunn M, Earthrowl ME, Ellington AG, Faulkner L, Frankish AG, Frankland J, French L, Garner P, Garnett J, Gilbert JG, Gilson CJ, Ghori J, Grafham DV, Gribble SM, Griffiths C, Hall RE, Hammond S, Harley JL, Hart EA, Heath PD, Howden PJ, Huckle EJ, Hunt PJ, Hunt AR, Johnson C, Johnson D, Kay M, Kimberley AM, King A, Laird GK, Langford CJ, Lawlor S, Leongamornlert DA, Lloyd DM, Lloyd C, Loveland JE, Lovell J, Martin S, Mashreghi-Mohammadi M, McLaren SJ, McMurray A, Milne S, Moore MJ, Nickerson T, Palmer SA, Pearce AV, Peck AI, Pelan S, Phillimore B, Porter KM, Rice CM, Searle S, Sehra HK, Shownkeen R, Skuce CD, Smith M, Steward CA, Sycamore N, Tester J, Thomas DW, Tracey A, Tromans A, Tubby B, Wall M, Wallis JM, West AP, Whitehead SL, Willey DL, Wilming L, Wray PW, Wright MW, Young L, Coulson A, Durbin R, Hubbard T, Sulston JE, Beck S, Bentley DR, Rogers J, Ross MT: The DNA sequence and analysis of human chromosome 13. Nature. 2004 Apr 1;428(6982):522-8. [PubMed:15057823 ]