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Identification
HMDB Protein ID HMDBP03692
Secondary Accession Numbers
  • 9280
Name Putative N-acetylglucosamine-6-phosphate deacetylase
Synonyms
  1. Amidohydrolase domain-containing protein 2
  2. GlcNAc 6-P deacetylase
Gene Name AMDHD2
Protein Type Enzyme
Biological Properties
General Function Involved in hydrolase activity
Specific Function Hydrolyzes the N-glycolyl group from N-glycolylglucosamine 6-phosphate (GlcNGc-6-P) in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway. Although human is not able to catalyze formation of Neu5Gc due to the inactive CMAHP enzyme, Neu5Gc is present in food and must be degraded.
Pathways
  • Amino sugar and nucleotide sugar metabolism
  • Amino Sugar Metabolism
  • G(M2)-Gangliosidosis: Variant B, Tay-sachs disease
  • N-acetylneuraminate degradation
  • Salla Disease/Infantile Sialic Acid Storage Disease
  • Sialuria or French Type Sialuria
  • Tay-Sachs Disease
Reactions
N-Acetyl-D-Glucosamine 6-Phosphate + Water → Glucosamine 6-phosphate + Acetic acid details
GO Classification
Biological Process
N-acetylneuraminate catabolic process
N-acetylglucosamine metabolic process
carbohydrate metabolic process
Function
catalytic activity
hydrolase activity
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
n-acetylglucosamine-6-phosphate deacetylase activity
Molecular Function
metal ion binding
N-acetylglucosamine-6-phosphate deacetylase activity
Process
metabolic process
small molecule metabolic process
alcohol metabolic process
monosaccharide metabolic process
amino sugar metabolic process
glucosamine metabolic process
n-acetylglucosamine metabolic process
Cellular Location
  1. Cytoplasmic
Gene Properties
Chromosome Location 16
Locus 16p13.3
SNPs AMDHD2
Gene Sequence
>1320 bp
ATGCGCGGCGAGCAGGGCGCGGCGGGGGCCCGCGTGCTCCAGTTCACTAACTGCCGGATC
CTGCGCGGAGGGAAACTGCTCAGGGAGGATCTGTGGGTGCGCGGAGGCCGCATCTTGGAC
CCAGAGAAGCTGTTCTTTGAGGAGCGGCGCGTGGCCGACGAGCGGCGGGACTGCGGGGGC
CGCATCTTGGCTCCCGGATTCATCGACGTGCAGATCAACGGTGGATTTGGTGTTGACTTC
TCTCAAGCCACGGAGGACGTGGGTTCGGGGGTTGCCCTCGTGGCCCGGAGGATCCTGTCG
CACGGCGTCACCTCCTTCTGCCCCACCCTGGTCACTTCCCCACCGGAGGTTTATCACAAG
GTTGTTCCTCAGATCCCTGTGAAGAGTGGTGGTCCCCATGGGGCAGGGGTCCTCGGGCTG
CACCTGGAGGGCCCCTTCATCAGCCGGGAGAAGCGGGGCGCGCACCCCGAGGCCCACCTC
CGCTCCTTCGAGGCCGATGCCTTCCAGGACTTGCTGGCCACCTACGGGCCCCTGGACAAT
GTCCGCATCGTGACGCTGGCCCCAGAGTTGGGCCGTAGCCACGAAGTGATCCGGGCGCTG
ACGGCCCGTGGCATCTGCGTGTCCCTAGGGCACTCAGTGGCTGACCTGCGGGCGGCAGAG
GATGCTGTGTGGAGCGGAGCCACCTTCATCACCCACCTCTTCAACGCCATGCTGCCTTTC
CACCACCGCGACCCAGGCATCGTGGGGCTCCTGACCAGCGACCGGCTGCCCGCAGGCCGC
TGCATCTTCTATGGGATGATTGCAGATGGCACGCACACCAACCCCGCCGCCCTGCGGATC
GCCCACCGTGCCCATCCCCAGGGGCTGGTGCTGGTCACCGATGCCATCCCTGCCTTGGGC
CTGGGCAACGGCCGGCACACGCTGGGACAGCAGGAAGTGGAAGTGGACGGTCTGACGGCC
TACGTGGCAGGTGAGCGCCCTGACCCACTGGGTCCCAGGTCCCAGCCCGCATGCCAGGTG
GCCCACGACCCCCCCAGAGCCTGCCCTCTCTGCTCTCAAGGCACCAAGACGCTGAGTGGC
AGCATAGCCCCAATGGACGTCTGTGTCCGGCACTTCCTGCAGGCCACAGGCTGCAGCATG
GAGTCGGCCCTGGAGGCTGCATCCCTGCACCCCGCCCAGTTGCTGGGGCTGGAGAAGAGT
AAGGGGACCCTGGACTTTGGTGCTGACGCAGACTTCGTGGTGCTCGACGACTCCCTTCAC
GTCCAGGCCACCTACATCTCGGGTGAGCTGGTGTGGCAGGCGGACGCAGCTAGGCAGTGA
Protein Properties
Number of Residues 409
Molecular Weight 63594.415
Theoretical pI 7.526
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>Putative N-acetylglucosamine-6-phosphate deacetylase
MRGEQGAAGARVLQFTNCRILRGGKLLREDLWVRGGRILDPEKLFFEERRVADERRDCGG
RILAPGFIDVQINGGFGVDFSQATEDVGSGVALVARRILSHGVTSFCPTLVTSPPEVYHK
VVPQIPVKSGGPHGAGVLGLHLEGPFISREKRGAHPEAHLRSFEADAFQDLLATYGPLDN
VRIVTLAPELGRSHEVIRALTARGICVSLGHSVADLRAAEDAVWSGATFITHLFNAMLPF
HHRDPGIVGLLTSDRLPAGRCIFYGMIADGTHTNPAALRIAHRAHPQGLVLVTDAIPALG
LGNGRHTLGQQEVEVDGLTAYVAGTKTLSGSIAPMDVCVRHFLQATGCSMESALEAASLH
PAQLLGLEKSKGTLDFGADADFVVLDDSLHVQATYISGELVWQADAARQ
GenBank ID Protein 21361513
UniProtKB/Swiss-Prot ID Q9Y303
UniProtKB/Swiss-Prot Entry Name NAGA_HUMAN
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID AMDHD2
GenAtlas ID AMDHD2
HGNC ID HGNC:24262
References
General References
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