Human Metabolome Database: Showing Protein Thymidine kinase, cytosolic (HMDBP03814)

Identification Biological properties Gene properties Protein properties External links References XML Show 9 metabolites

Identification

HMDB Protein ID

HMDBP03814

Secondary Accession Numbers

9402

Name

Thymidine kinase, cytosolic

Synonyms

Not Available

Gene Name

TK1

Protein Type

Enzyme

Biological Properties

General Function

Nucleotide transport and metabolism

Specific Function

Not Available

Pathways

Beta Ureidopropionase Deficiency
Dihydropyrimidinase Deficiency
Drug metabolism - other enzymes
MNGIE (Mitochondrial Neurogastrointestinal Encephalopathy)
Pyrimidine metabolism
Pyrimidine metabolism
UMP Synthase Deficiency (Orotic Aciduria)

Reactions

Adenosine triphosphate + Thymidine → ADP + 5-Thymidylic acid	details
Adenosine triphosphate + Deoxyuridine → ADP + dUMP	details
Floxuridine + Adenosine triphosphate → 5-Fluorodeoxyuridine monophosphate + ADP	details

GO Classification

Biological Process
pyrimidine nucleoside salvage
pyrimidine nucleobase metabolic process
DNA replication
protein homotetramerization
Cellular Component
cytosol
Function
purine nucleotide binding
binding
nucleotide binding
catalytic activity
transferase activity
transferase activity, transferring phosphorus-containing groups
kinase activity
nucleobase, nucleoside, nucleotide kinase activity
adenyl nucleotide binding
atp binding
nucleoside kinase activity
deoxynucleoside kinase activity
thymidine kinase activity
Molecular Function
thymidine kinase activity
metal ion binding
ATP binding
zinc ion binding

Cellular Location

Cytoplasm

Gene Properties

Chromosome Location

Locus

17q23.2-q25.3

SNPs

TK1

Gene Sequence

>705 bp
ATGAGCTGCATTAACCTGCCCACTGTGCTGCCCGGCTCCCCCAGCAAGACCCGGGGGCAG
ATCCAGGTGATTCTCGGGCCGATGTTCTCAGGAAAAAGCACAGAGTTGATGAGACGCGTC
CGTCGCTTCCAGATTGCTCAGTACAAGTGCCTGGTGATCAAGTATGCCAAAGACACTCGC
TACAGCAGCAGCTTCTGCACACATGACCGGAACACCATGGAGGCGCTGCCCGCCTGCCTG
CTCCGAGACGTGGCCCAGGAGGCCCTGGGCGTGGCTGTCATAGGCATCGACGAGGGGCAG
TTTTTCCCTGACATCATGGAGTTCTGCGAGGCCATGGCCAACGCCGGGAAGACCGTAATT
GTGGCTGCACTGGATGGGACCTTCCAGAGGAAGCCATTTGGGGCCATCCTGAACCTGGTG
CCGCTGGCCGAGAGCGTGGTGAAGCTGACGGCGGTGTGCATGGAGTGCTTCCGGGAAGCC
GCCTATACCAAGAGGCTCGGCACAGAGAAGGAGGTCGAGGTGATTGGGGGAGCAGACAAG
TACCACTCCGTGTGTCGGCTCTGCTACTTCAAGAAGGCCTCAGGCCAGCCTGCCGGGCCG
GACAACAAAGAGAACTGCCCAGTGCCAGGAAAGCCAGGGGAAGCCGTGGCTGCCAGGAAG
CTCTTTGCCCCACAGCAGATTCTGCAATGCAGCCCTGCCAACTGA

Protein Properties

Number of Residues

234

Molecular Weight

25468.455

Theoretical pI

8.51

Pfam Domain Function

TK (PF00265 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>Thymidine kinase, cytosolic
MSCINLPTVLPGSPSKTRGQIQVILGPMFSGKSTELMRRVRRFQIAQYKCLVIKYAKDTR
YSSSFCTHDRNTMEALPACLLRDVAQEALGVAVIGIDEGQFFPDIVEFCEAMANAGKTVI
VAALDGTFQRKPFGAILNLVPLAESVVKLTAVCMECFREAAYTKRLGTEKEVEVIGGADK
YHSVCRLCYFKKASGQPAGPDNKENCPVPGKPGEAVAARKLFAPQQILQCSPAN

External Links

GenBank ID Protein

339709

UniProtKB/Swiss-Prot ID

P04183

UniProtKB/Swiss-Prot Entry Name

KITH_HUMAN

PDB IDs

GenBank Gene ID

GeneCard ID

GenAtlas ID

HGNC ID

References

General References

Bradshaw HD Jr, Deininger PL: Human thymidine kinase gene: molecular cloning and nucleotide sequence of a cDNA expressible in mammalian cells. Mol Cell Biol. 1984 Nov;4(11):2316-20. [PubMed:6549046 ]
Flemington E, Bradshaw HD Jr, Traina-Dorge V, Slagel V, Deininger PL: Sequence, structure and promoter characterization of the human thymidine kinase gene. Gene. 1987;52(2-3):267-77. [PubMed:3301530 ]
Chang ZF, Huang DY, Chi LM: Serine 13 is the site of mitotic phosphorylation of human thymidine kinase. J Biol Chem. 1998 May 15;273(20):12095-100. [PubMed:9575153 ]