| Identification |
|---|
| HMDB Protein ID
| HMDBP03814 |
| Secondary Accession Numbers
| |
| Name
| Thymidine kinase, cytosolic |
| Synonyms
|
Not Available
|
| Gene Name
| TK1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Nucleotide transport and metabolism |
| Specific Function
| Not Available |
| Pathways
|
- Beta Ureidopropionase Deficiency
- Dihydropyrimidinase Deficiency
- Drug metabolism - other enzymes
- MNGIE (Mitochondrial Neurogastrointestinal Encephalopathy)
- Pyrimidine metabolism
- Pyrimidine metabolism
- UMP Synthase Deficiency (Orotic Aciduria)
|
| Reactions
|
| Adenosine triphosphate + Thymidine → ADP + 5-Thymidylic acid |
details
|
| Adenosine triphosphate + Deoxyuridine → ADP + dUMP |
details
|
| Floxuridine + Adenosine triphosphate → 5-Fluorodeoxyuridine monophosphate + ADP |
details
|
|
| GO Classification
|
| Biological Process |
| pyrimidine nucleoside salvage |
| pyrimidine nucleobase metabolic process |
| DNA replication |
| protein homotetramerization |
| Cellular Component |
| cytosol |
| Function |
| purine nucleotide binding |
| binding |
| nucleotide binding |
| catalytic activity |
| transferase activity |
| transferase activity, transferring phosphorus-containing groups |
| kinase activity |
| nucleobase, nucleoside, nucleotide kinase activity |
| adenyl nucleotide binding |
| atp binding |
| nucleoside kinase activity |
| deoxynucleoside kinase activity |
| thymidine kinase activity |
| Molecular Function |
| thymidine kinase activity |
| metal ion binding |
| ATP binding |
| zinc ion binding |
|
| Cellular Location
|
- Cytoplasm
|
| Gene Properties |
|---|
| Chromosome Location
| 17 |
| Locus
| 17q23.2-q25.3 |
| SNPs
| TK1 |
| Gene Sequence
|
>705 bp
ATGAGCTGCATTAACCTGCCCACTGTGCTGCCCGGCTCCCCCAGCAAGACCCGGGGGCAG
ATCCAGGTGATTCTCGGGCCGATGTTCTCAGGAAAAAGCACAGAGTTGATGAGACGCGTC
CGTCGCTTCCAGATTGCTCAGTACAAGTGCCTGGTGATCAAGTATGCCAAAGACACTCGC
TACAGCAGCAGCTTCTGCACACATGACCGGAACACCATGGAGGCGCTGCCCGCCTGCCTG
CTCCGAGACGTGGCCCAGGAGGCCCTGGGCGTGGCTGTCATAGGCATCGACGAGGGGCAG
TTTTTCCCTGACATCATGGAGTTCTGCGAGGCCATGGCCAACGCCGGGAAGACCGTAATT
GTGGCTGCACTGGATGGGACCTTCCAGAGGAAGCCATTTGGGGCCATCCTGAACCTGGTG
CCGCTGGCCGAGAGCGTGGTGAAGCTGACGGCGGTGTGCATGGAGTGCTTCCGGGAAGCC
GCCTATACCAAGAGGCTCGGCACAGAGAAGGAGGTCGAGGTGATTGGGGGAGCAGACAAG
TACCACTCCGTGTGTCGGCTCTGCTACTTCAAGAAGGCCTCAGGCCAGCCTGCCGGGCCG
GACAACAAAGAGAACTGCCCAGTGCCAGGAAAGCCAGGGGAAGCCGTGGCTGCCAGGAAG
CTCTTTGCCCCACAGCAGATTCTGCAATGCAGCCCTGCCAACTGA
|
| Protein Properties |
|---|
| Number of Residues
| 234 |
| Molecular Weight
| 25468.455 |
| Theoretical pI
| 8.51 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Thymidine kinase, cytosolic
MSCINLPTVLPGSPSKTRGQIQVILGPMFSGKSTELMRRVRRFQIAQYKCLVIKYAKDTR
YSSSFCTHDRNTMEALPACLLRDVAQEALGVAVIGIDEGQFFPDIVEFCEAMANAGKTVI
VAALDGTFQRKPFGAILNLVPLAESVVKLTAVCMECFREAAYTKRLGTEKEVEVIGGADK
YHSVCRLCYFKKASGQPAGPDNKENCPVPGKPGEAVAARKLFAPQQILQCSPAN
|
| External Links |
|---|
| GenBank ID Protein
| 339709 |
| UniProtKB/Swiss-Prot ID
| P04183 |
| UniProtKB/Swiss-Prot Entry Name
| KITH_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| K02581 |
| GeneCard ID
| TK1 |
| GenAtlas ID
| TK1 |
| HGNC ID
| HGNC:11830 |
| References |
|---|
| General References
| - Bradshaw HD Jr, Deininger PL: Human thymidine kinase gene: molecular cloning and nucleotide sequence of a cDNA expressible in mammalian cells. Mol Cell Biol. 1984 Nov;4(11):2316-20. [PubMed:6549046 ]
- Flemington E, Bradshaw HD Jr, Traina-Dorge V, Slagel V, Deininger PL: Sequence, structure and promoter characterization of the human thymidine kinase gene. Gene. 1987;52(2-3):267-77. [PubMed:3301530 ]
- Chang ZF, Huang DY, Chi LM: Serine 13 is the site of mitotic phosphorylation of human thymidine kinase. J Biol Chem. 1998 May 15;273(20):12095-100. [PubMed:9575153 ]
|
