Showing Protein Solute carrier family 2, facilitated glucose transporter member 2 (HMDBP05474)

• 11073

1. GLUT-2
2. Glucose transporter type 2, liver

• Carbohydrate digestion and absorption
• Fanconi-bickel syndrome
• Fructose-1,6-diphosphatase deficiency
• Glibenclamide Action Pathway
• Gliclazide Action Pathway
• Gluconeogenesis
• Glucose-Alanine Cycle
• Glycogen Storage Disease Type 1A (GSD1A) or Von Gierke Disease
• Glycogenosis, Type IA. Von gierke disease
• Glycogenosis, Type IB
• Glycogenosis, Type IC
• Glycogenosis, Type VII. Tarui disease
• Glycolysis
• Insulin secretion
• Lactose Degradation
• Lactose Intolerance
• Maturity onset diabetes of the young
• Nateglinide Action Pathway
• Pancreas Function
• Phosphoenolpyruvate carboxykinase deficiency 1 (PEPCK1)
• Repaglinide Action Pathway
• Trehalose Degradation
• Triosephosphate isomerase
• Type II diabetes mellitus
• Warburg Effect

1. Membrane
2. Multi-pass membrane protein

>1575 bp
ATGACAGAAGATAAGGTCACTGGGACCCTGGTTTTCACTGTCATCACTGCTGTGCTGGGT
TCCTTCCAGTTTGGATATGACATTGGTGTGATCAATGCACCTCAACAGGTAATAATATCT
CACTATAGACATGTTTTGGGTGTTCCACTGGATGACCGAAAAGCTATCAACAACTATGTT
ATCAACAGTACAGATGAACTGCCCACAATCTCATACTCAATGAACCCAAAACCAACCCCT
TGGGCTGAGGAAGAGACTGTGGCAGCTGCTCAACTAATCACCATGCTCTGGTCCCTGTCT
GTATCCAGCTTTGCAGTTGGTGGAATGACTGCATCATTCTTTGGTGGGTGGCTTGGGGAC
ACACTTGGAAGAATCAAAGCCATGTTAGTAGCAAACATTCTGTCATTAGTTGGAGCTCTC
TTGATGGGGTTTTCAAAATTGGGACCATCTCATATACTTATAATTGCTGGAAGAAGCATA
TCAGGACTATATTGTGGGCTAATTTCAGGCCTGGTTCCTATGTATATCGGTGAAATTGCT
CCAACCGCTCTCAGGGGAGCACTTGGCACTTTTCATCAGCTGGCCATCGTCACGGGCATT
CTTATTAGTCAGATTATTGGTCTTGAATTTATCTTGGGCAATTATGATCTGTGGCACATC
CTGCTTGGCCTGTCTGGTGTGCGAGCCATCCTTCAGTCTCTGCTACTCTTTTTCTGTCCA
GAAAGCCCCAGATACCTTTACATCAAGTTAGATGAGGAAGTCAAAGCAAAACAAAGCTTG
AAAAGACTCAGAGGATATGATGATGTCACCAAAGATATTAATGAAATGAGAAAAGAAAGA
GAAGAAGCATCGAGTGAGCAGAAAGTCTCTATAATTCAGCTCTTCACCAATTCCAGCTAC
CGACAGCCTATTCTAGTGGCACTGATGCTGCATGTGGCTCAGCAATTTTCCGGAATCAAT
GGCATTTTTTACTACTCAACCAGCATTTTTCAGACGGCTGGTATCAGCAAACCTGTTTAT
GCAACCATTGGAGTTGGCGCTGTAAACATGGTTTTCACTGCTGTCTCTGTATTCCTTGTG
GAGAAGGCAGGGCGACGTTCTCTCTTTCTAATTGGAATGAGTGGGATGTTTGTTTGTGCC
ATCTTCATGTCAGTGGGACTTGTGCTGCTGAATAAGTTCTCTTGGATGAGTTATGTGAGC
ATGATAGCCATCTTCCTCTTTGTCAGCTTCTTTGAAATTGGGCCAGGCCCGATCCCCTGG
TTCATGGTGGCTGAGTTTTTCAGTCAAGGACCACGTCCTGCTGCTTTAGCAATAGCTGCA
TTCAGCAATTGGACCTGCAATTTCATTGTAGCTCTGTGTTTCCAGTACATTGCGGACTTC
TGTGGACCTTATGTGTTTTTCCTCTTTGCTGGAGTGCTCCTGGCCTTTACCCTGTTCACA
TTTTTTAAAGTTCCAGAAACCAAAGGAAAGTCTTTTGAGGAAATTGCTGCAGAATTCCAA
AAGAAGAGTGGCTCAGCCCACAGGCCAAAAGCTGCTGTAGAAATGAAATTCCTAGGAGCT
ACAGAGACTGTGTAA

• Sugar_tr (PF00083 )

>Solute carrier family 2, facilitated glucose transporter member 2
MTEDKVTGTLVFTVITAVLGSFQFGYDIGVINAPQQVIISHYRHVLGVPLDDRKAINNYV
INSTDELPTISYSMNPKPTPWAEEETVAAAQLITMLWSLSVSSFAVGGMTASFFGGWLGD
TLGRIKAMLVANILSLVGALLMGFSKLGPSHILIIAGRSISGLYCGLISGLVPMYIGEIA
PTALRGALGTFHQLAIVTGILISQIIGLEFILGNYDLWHILLGLSGVRAILQSLLLFFCP
ESPRYLYIKLDEEVKAKQSLKRLRGYDDVTKDINEMRKEREEASSEQKVSIIQLFTNSSY
RQPILVALMLHVAQQFSGINGIFYYSTSIFQTAGISKPVYATIGVGAVNMVFTAVSVFLV
EKAGRRSLFLIGMSGMFVCAIFMSVGLVLLNKFSWMSYVSMIAIFLFVSFFEIGPGPIPW
FMVAEFFSQGPRPAALAIAAFSNWTCNFIVALCFQYIADFCGPYVFFLFAGVLLAFTLFT
FFKVPETKGKSFEEIAAEFQKKSGSAHRPKAAVEMKFLGATETV

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2. Fukumoto H, Seino S, Imura H, Seino Y, Eddy RL, Fukushima Y, Byers MG, Shows TB, Bell GI: Sequence, tissue distribution, and chromosomal localization of mRNA encoding a human glucose transporter-like protein. Proc Natl Acad Sci U S A. 1988 Aug;85(15):5434-8. [PubMed:3399500 ]
3. Matsubara A, Tanizawa Y, Matsutani A, Kaneko T, Kaku K: Sequence variations of the pancreatic islet/liver glucose transporter (GLUT2) gene in Japanese subjects with noninsulin dependent diabetes mellitus. J Clin Endocrinol Metab. 1995 Nov;80(11):3131-5. [PubMed:7593414 ]
4. Tanizawa Y, Riggs AC, Chiu KC, Janssen RC, Bell DS, Go RP, Roseman JM, Acton RT, Permutt MA: Variability of the pancreatic islet beta cell/liver (GLUT 2) glucose transporter gene in NIDDM patients. Diabetologia. 1994 Apr;37(4):420-7. [PubMed:8063045 ]
5. Mueckler M, Kruse M, Strube M, Riggs AC, Chiu KC, Permutt MA: A mutation in the Glut2 glucose transporter gene of a diabetic patient abolishes transport activity. J Biol Chem. 1994 Jul 8;269(27):17765-7. [PubMed:8027028 ]
6. Burwinkel B, Sanjad SA, Al-Sabban E, Al-Abbad A, Kilimann MW: A mutation in GLUT2, not in phosphorylase kinase subunits, in hepato-renal glycogenosis with Fanconi syndrome and low phosphorylase kinase activity. Hum Genet. 1999 Sep;105(3):240-3. [PubMed:10987651 ]
7. Sakamoto O, Ogawa E, Ohura T, Igarashi Y, Matsubara Y, Narisawa K, Iinuma K: Mutation analysis of the GLUT2 gene in patients with Fanconi-Bickel syndrome. Pediatr Res. 2000 Nov;48(5):586-9. [PubMed:11044475 ]