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Identification
HMDB Protein ID HMDBP05907
Secondary Accession Numbers
  • 11509
Name Alpha-(1,3)-fucosyltransferase
Synonyms
  1. Fuc-TIX
  2. FucT-IX
  3. Fucosyltransferase 9
  4. Fucosyltransferase IX
  5. Galactoside 3-L-fucosyltransferase
Gene Name FUT9
Protein Type Enzyme
Biological Properties
General Function Involved in fucosyltransferase activity
Specific Function Transfers a fucose to lacto-N-neotetraose but not to either alpha2,3-sialyl lacto-N-neotetraose or lacto-N-tetraose. Can catalyze the last step in the biosynthesis of Lewis antigen, the addition of a fucose to precursor polysaccharides
Pathways Not Available
Reactions Not Available
GO Classification
Component
membrane
cell part
Function
catalytic activity
transferase activity
transferase activity, transferring hexosyl groups
transferase activity, transferring glycosyl groups
fucosyltransferase activity
Process
metabolic process
macromolecule metabolic process
macromolecule modification
protein modification process
protein amino acid glycosylation
Cellular Location
  1. Single-pass type II membrane protein
  2. Golgi apparatus
  3. Golgi stack membrane
Gene Properties
Chromosome Location Chromosome:6
Locus 6q16
SNPs FUT9
Gene Sequence
>1080 bp
ATGACATCAACATCCAAAGGAATTCTTCGCCCATTTTTAATTGTCTGCATTATCCTGGGC
TGTTTCATGGCATGTCTTCTCATTTACATCAAACCTACCAACAGCTGGATCTTCAGTCCA
ATGGAATCAGCCAGCTCTGTGCTGAAAATGAAAAACTTCTTTTCCACCAAAACTGATTAT
TTTAATGAAACTACTATTCTGGTGTGGGTGTGGCCATTTGGGCAGACCTTTGACCTTACA
TCCTGCCAAGCAATGTTCAACATCCAAGGATGCCATCTCACAACGGACCGTTCACTGTAC
AACAAATCCCATGCAGTTCTGATCCATCACCGAGACATCAGTTGGGATCTGACAAATTTA
CCTCAGCAAGCTAGGCCACCCTTCCAGAAATGGATTTGGATGAATTTGGAATCACCAACT
CACACTCCCCAAAAGAGTGGCATTGAGCACTTGTTTAACCTGACTCTGACTTACCGCCGT
GATTCAGATATCCAAGTGCCTTATGGCTTCTTGACGGTAAGCACAAATCCCTTCGTGTTT
GAAGTGCCAAGCAAAGAGAAATTGGTGTGCTGGGTTGTGAGTAACTGGAACCCTGAGCAT
GCCAGAGTCAAGTATTACAATGAGCTAAGCAAAAGCATTGAAATCCATACCTACGGGCAA
GCATTTGGAGAATATGTCAATGATAAAAATTTGATTCCTACCATATCTGCTTGTAAATTT
TATCTTTCCTTTGAAAATTCAATCCACAAGGATTACATCACGGAAAAGCTATACAATGCT
TTTCTGGCTGGCTCTGTACCTGTTGTTCTGGGACCATCTAGGGAAAACTATGAGAATTAT
ATTCCAGCAGATTCATTCATTCATGTGGAAGATTATAACTCTCCCAGTGAGCTAGCAAAG
TATCTGAAGGAAGTCGACAAAAACAATAAGTTATACCTTAGTTACTTTAACTGGAGGAAG
GATTTCACTGTAAATCTTCCACGATTTTGGGAATCACATGCATGTTTGGCTTGCGATCAT
GTGAAAAGGCATCAAGAATATAAGTCTGTTGGTAATTTAGAGAAATGGTTTTGGAATTAA
Protein Properties
Number of Residues 359
Molecular Weight 42040.7
Theoretical pI 7.77
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • 12-32
Protein Sequence
>Alpha-(1,3)-fucosyltransferase
MTSTSKGILRPFLIVCIILGCFMACLLIYIKPTNSWIFSPMESASSVLKMKNFFSTKTDY
FNETTILVWVWPFGQTFDLTSCQAMFNIQGCHLTTDRSLYNKSHAVLIHHRDISWDLTNL
PQQARPPFQKWIWMNLESPTHTPQKSGIEHLFNLTLTYRRDSDIQVPYGFLTVSTNPFVF
EVPSKEKLVCWVVSNWNPEHARVKYYNELSKSIEIHTYGQAFGEYVNDKNLIPTISACKF
YLSFENSIHKDYITEKLYNAFLAGSVPVVLGPSRENYENYIPADSFIHVEDYNSPSELAK
YLKEVDKNNKLYLSYFNWRKDFTVNLPRFWESHACLACDHVKRHQEYKSVGNLEKWFWN
GenBank ID Protein 5139693
UniProtKB/Swiss-Prot ID Q9Y231
UniProtKB/Swiss-Prot Entry Name FUT9_HUMAN
PDB IDs Not Available
GenBank Gene ID AB023021
GeneCard ID FUT9
GenAtlas ID FUT9
HGNC ID HGNC:4020
References
General References
  1. Mungall AJ, Palmer SA, Sims SK, Edwards CA, Ashurst JL, Wilming L, Jones MC, Horton R, Hunt SE, Scott CE, Gilbert JG, Clamp ME, Bethel G, Milne S, Ainscough R, Almeida JP, Ambrose KD, Andrews TD, Ashwell RI, Babbage AK, Bagguley CL, Bailey J, Banerjee R, Barker DJ, Barlow KF, Bates K, Beare DM, Beasley H, Beasley O, Bird CP, Blakey S, Bray-Allen S, Brook J, Brown AJ, Brown JY, Burford DC, Burrill W, Burton J, Carder C, Carter NP, Chapman JC, Clark SY, Clark G, Clee CM, Clegg S, Cobley V, Collier RE, Collins JE, Colman LK, Corby NR, Coville GJ, Culley KM, Dhami P, Davies J, Dunn M, Earthrowl ME, Ellington AE, Evans KA, Faulkner L, Francis MD, Frankish A, Frankland J, French L, Garner P, Garnett J, Ghori MJ, Gilby LM, Gillson CJ, Glithero RJ, Grafham DV, Grant M, Gribble S, Griffiths C, Griffiths M, Hall R, Halls KS, Hammond S, Harley JL, Hart EA, Heath PD, Heathcott R, Holmes SJ, Howden PJ, Howe KL, Howell GR, Huckle E, Humphray SJ, Humphries MD, Hunt AR, Johnson CM, Joy AA, Kay M, Keenan SJ, Kimberley AM, King A, Laird GK, Langford C, Lawlor S, Leongamornlert DA, Leversha M, Lloyd CR, Lloyd DM, Loveland JE, Lovell J, Martin S, Mashreghi-Mohammadi M, Maslen GL, Matthews L, McCann OT, McLaren SJ, McLay K, McMurray A, Moore MJ, Mullikin JC, Niblett D, Nickerson T, Novik KL, Oliver K, Overton-Larty EK, Parker A, Patel R, Pearce AV, Peck AI, Phillimore B, Phillips S, Plumb RW, Porter KM, Ramsey Y, Ranby SA, Rice CM, Ross MT, Searle SM, Sehra HK, Sheridan E, Skuce CD, Smith S, Smith M, Spraggon L, Squares SL, Steward CA, Sycamore N, Tamlyn-Hall G, Tester J, Theaker AJ, Thomas DW, Thorpe A, Tracey A, Tromans A, Tubby B, Wall M, Wallis JM, West AP, White SS, Whitehead SL, Whittaker H, Wild A, Willey DJ, Wilmer TE, Wood JM, Wray PW, Wyatt JC, Young L, Younger RM, Bentley DR, Coulson A, Durbin R, Hubbard T, Sulston JE, Dunham I, Rogers J, Beck S: The DNA sequence and analysis of human chromosome 6. Nature. 2003 Oct 23;425(6960):805-11. [PubMed:14574404 ]
  2. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  3. Kaneko M, Kudo T, Iwasaki H, Ikehara Y, Nishihara S, Nakagawa S, Sasaki K, Shiina T, Inoko H, Saitou N, Narimatsu H: Alpha1,3-fucosyltransferase IX (Fuc-TIX) is very highly conserved between human and mouse; molecular cloning, characterization and tissue distribution of human Fuc-TIX. FEBS Lett. 1999 Jun 11;452(3):237-42. [PubMed:10386598 ]
  4. Cailleau-Thomas A, Coullin P, Candelier JJ, Balanzino L, Mennesson B, Oriol R, Mollicone R: FUT4 and FUT9 genes are expressed early in human embryogenesis. Glycobiology. 2000 Aug;10(8):789-802. [PubMed:10929005 ]