Hmdb loader
Identification
HMDB Protein ID HMDBP06256
Secondary Accession Numbers
  • 11859
Name UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7
Synonyms
  1. BGnT-7
  2. Beta-1,3-Gn-T7
  3. Beta-1,3-N-acetylglucosaminyltransferase 7
  4. Beta3Gn-T7
Gene Name B3GNT7
Protein Type Enzyme
Biological Properties
General Function Involved in galactosyltransferase activity
Specific Function May be involved in keratane sulfate biosynthesis. Transfers N-acetylgalactosamine on to keratan sulfate-related glycans. May play a role in preventing cells from migrating out of the original tissues and invading surrounding tissues
Pathways Not Available
Reactions Not Available
GO Classification
Component
membrane
cell part
Function
galactosyltransferase activity
catalytic activity
transferase activity
transferase activity, transferring hexosyl groups
transferase activity, transferring glycosyl groups
Process
metabolic process
macromolecule metabolic process
macromolecule modification
protein modification process
protein amino acid glycosylation
Cellular Location
  1. Golgi apparatus membrane
  2. Single-pass type II membrane protein (Potential)
Gene Properties
Chromosome Location Chromosome:2
Locus 2q37.1
SNPs B3GNT7
Gene Sequence
>1206 bp
ATGTCGCTGTGGAAGAAAACCGTCTACCGGAGTCTGTGCCTGGCCCTGGCCCTGCTCGTG
GCCGTGACGGTGTTCCAACGCAGTCTCACCCCTGGTCAGTTTCTGCAGGAGCCTCCGCCA
CCCACCCTGGAGCCACAGAAGGCCCAGAAGCCAAATGGACAGCTGGTGAACCCCAACAAC
TTCTGGAAGAACCCGAAAGATGTGGCTGCGCCCACGCCCATGGCCTCTCAGGGGCCCCAG
GCCTGGGACGTGACCACCACTAACTGCTCAGCCAATATCAACTTGACCCACCAGCCCTGG
TTCCAGGTCCTGGAGCCGCAGTTCCGGCAGTTTCTCTTCTACCGCCACTGCCGCTACTTC
CCCATGCTGCTGAACCACCCGGAGAAGTGCAGGGGCGATGTCTACCTGCTGGTGGTTGTC
AAGTCGGTCATCACGCAGCACGACCGCCGCGAGGCCATCCGCCAGACCTGGGGCCGCGAG
CGGCAGTCCGCGGGTGGGGGCCGAGGCGCCGTGCGCACCCTCTTCCTGCTGGGCACGGCC
TCCAAGCAGGAGGAGCGCACGCACTACCAGCAGCTGCTGGCCTACGAAGACCGCCTCTAC
GGCGACATCCTGCAGTGGGGCTTTCTCGACACCTTCTTCAACCTGACCCTCAAGGAGATC
CACTTCCTCAAGTGGCTGGACATCTACTGCCCCCACGTCCCCTTCATTTTCAAAGGCGAC
GATGACGTCTTCGTCAACCCCACCAACCTGCTAGAATTTCTGGCTGACCGGCAGCCACAG
GAAAACCTGTTCGTGGGCGATGTCCTGCAGCACGCTCGGCCCATTCGCAGGAAAGACAAC
AAATACTACATCCCGGGGGCCCTGTACGGCAAGGCCAGCTATCCGCCGTATGCAGGCGGC
GGTGGCTTCCTCATGGCCGGCAGCCTGGCCCGGCGCCTGCACCATGCCTGCGACACCCTG
GAGCTCTACCCGATCGACGACGTCTTTCTGGGCATGTGCCTGGAGGTGCTGGGCGTGCAG
CCCACGGCCCACGAGGGCTTCAAGACTTTCGGCATCTCCCGGAACCGCAACAGCCGCATG
AACAAGGAGCCGTGCTTTTTCCGCGCCATGCTCGTGGTGCACAAGCTGCTGCCCCCTGAG
CTGCTCGCCATGTGGGGGCTGGTGCACAGCAATCTCACCTGCTCCCGCAAGCTCCAGGTG
CTCTGA
Protein Properties
Number of Residues 401
Molecular Weight 45986.9
Theoretical pI 9.29
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • 7-26
Protein Sequence
>UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7
MSLWKKTVYRSLCLALALLVAVTVFQRSLTPGQFLQEPPPPTLEPQKAQKPNGQLVNPNN
FWKNPKDVAAPTPMASQGPQAWDVTTTNCSANINLTHQPWFQVLEPQFRQFLFYRHCRYF
PMLLNHPEKCRGDVYLLVVVKSVITQHDRREAIRQTWGRERQSAGGGRGAVRTLFLLGTA
SKQEERTHYQQLLAYEDRLYGDILQWGFLDTFFNLTLKEIHFLKWLDIYCPHVPFIFKGD
DDVFVNPTNLLEFLADRQPQENLFVGDVLQHARPIRRKDNKYYIPGALYGKASYPPYAGG
GGFLMAGSLARRLHHACDTLELYPIDDVFLGMCLEVLGVQPTAHEGFKTFGISRNRNSRM
NKEPCFFRAMLVVHKLLPPELLAMWGLVHSNLTCSRKLQVL
GenBank ID Protein 62988859
UniProtKB/Swiss-Prot ID Q8NFL0
UniProtKB/Swiss-Prot Entry Name B3GN7_HUMAN
PDB IDs Not Available
GenBank Gene ID AC017104
GeneCard ID B3GNT7
GenAtlas ID B3GNT7
HGNC ID HGNC:18811
References
General References
  1. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [PubMed:14702039 ]
  2. Hillier LW, Graves TA, Fulton RS, Fulton LA, Pepin KH, Minx P, Wagner-McPherson C, Layman D, Wylie K, Sekhon M, Becker MC, Fewell GA, Delehaunty KD, Miner TL, Nash WE, Kremitzki C, Oddy L, Du H, Sun H, Bradshaw-Cordum H, Ali J, Carter J, Cordes M, Harris A, Isak A, van Brunt A, Nguyen C, Du F, Courtney L, Kalicki J, Ozersky P, Abbott S, Armstrong J, Belter EA, Caruso L, Cedroni M, Cotton M, Davidson T, Desai A, Elliott G, Erb T, Fronick C, Gaige T, Haakenson W, Haglund K, Holmes A, Harkins R, Kim K, Kruchowski SS, Strong CM, Grewal N, Goyea E, Hou S, Levy A, Martinka S, Mead K, McLellan MD, Meyer R, Randall-Maher J, Tomlinson C, Dauphin-Kohlberg S, Kozlowicz-Reilly A, Shah N, Swearengen-Shahid S, Snider J, Strong JT, Thompson J, Yoakum M, Leonard S, Pearman C, Trani L, Radionenko M, Waligorski JE, Wang C, Rock SM, Tin-Wollam AM, Maupin R, Latreille P, Wendl MC, Yang SP, Pohl C, Wallis JW, Spieth J, Bieri TA, Berkowicz N, Nelson JO, Osborne J, Ding L, Meyer R, Sabo A, Shotland Y, Sinha P, Wohldmann PE, Cook LL, Hickenbotham MT, Eldred J, Williams D, Jones TA, She X, Ciccarelli FD, Izaurralde E, Taylor J, Schmutz J, Myers RM, Cox DR, Huang X, McPherson JD, Mardis ER, Clifton SW, Warren WC, Chinwalla AT, Eddy SR, Marra MA, Ovcharenko I, Furey TS, Miller W, Eichler EE, Bork P, Suyama M, Torrents D, Waterston RH, Wilson RK: Generation and annotation of the DNA sequences of human chromosomes 2 and 4. Nature. 2005 Apr 7;434(7034):724-31. [PubMed:15815621 ]
  3. Kataoka K, Huh NH: A novel beta1,3-N-acetylglucosaminyltransferase involved in invasion of cancer cells as assayed in vitro. Biochem Biophys Res Commun. 2002 Jun 21;294(4):843-8. [PubMed:12061784 ]
  4. Seko A, Yamashita K: beta1,3-N-Acetylglucosaminyltransferase-7 (beta3Gn-T7) acts efficiently on keratan sulfate-related glycans. FEBS Lett. 2004 Jan 2;556(1-3):216-20. [PubMed:14706853 ]