Human Metabolome Database: Showing Protein Sodium/hydrogen exchanger 4 (HMDBP06889)

Identification Biological properties Gene properties Protein properties External links References XML Show 2 metabolites

Identification

HMDB Protein ID

HMDBP06889

Secondary Accession Numbers

12508

Name

Sodium/hydrogen exchanger 4

Synonyms

NHE-4
Na(+)/H(+) exchanger 4
Solute carrier family 9 member 4

Gene Name

SLC9A4

Protein Type

Unknown

Biological Properties

General Function

Involved in solute:hydrogen antiporter activity

Specific Function

Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction. May play a specialized role in the kidney in rectifying cell volume in response to extreme fluctuations of hyperosmolar-stimulated cell shrinkage. Is relatively amiloride and ethylisopropylamiloride (EIPA) insensitive. Can be activated under conditions of hyperosmolar-induced cell shrinkage in a sustained intracellular acidification-dependence manner. Activated by 4,4'-diisothiocyanostilbene-2,2'-disulfonic acid (DIDS) in a sustained intracellular acidification-dependence manner. Affects potassium/proton exchange as well as sodium/proton and lithium/proton exchange. In basolateral cell membrane, participates in homeostatic control of intracellular pH, and may play a role in proton extrusion in order to achieve transepithelial HCO3(-) secretion. In apical cell membrane may be involved in mediating sodium absorption. Requires for normal levels of gastric acid secretion, secretory membrane development, parietal cell maturation and/or differentiation and at least secondarily for chief cell differentiation

Pathways

Not Available

Reactions

Not Available

GO Classification

Component
cell part
membrane part
intrinsic to membrane
integral to membrane
Function
monovalent cation:hydrogen antiporter activity
sodium:hydrogen antiporter activity
solute:cation antiporter activity
solute:hydrogen antiporter activity
transmembrane transporter activity
substrate-specific transmembrane transporter activity
ion transmembrane transporter activity
cation transmembrane transporter activity
inorganic cation transmembrane transporter activity
monovalent inorganic cation transmembrane transporter activity
hydrogen ion transmembrane transporter activity
transporter activity
Process
cation homeostasis
monovalent inorganic cation homeostasis
regulation of ph
sodium ion transport
establishment of localization
transport
biological regulation
transmembrane transport
monovalent inorganic cation transport
ion transport
cation transport
regulation of biological quality
homeostatic process
chemical homeostasis
ion homeostasis

Cellular Location

Multi-pass membrane protein
Multi-pass membrane protein
Multi-pass membrane protein
Basolateral cell membrane
Apical cell membrane
Cytoplasmic granule membrane

Gene Properties

Chromosome Location

Chromosome:2

Locus

2q12.1

SNPs

SLC9A4

Gene Sequence

>2397 bp
ATGGCTCTGCAGATGTTCGTGACTTACAGTCCTTGGAATTGTTTGCTACTGCTAGTGGCT
CTTGAGTGTTCTGAAGCATCTTCTGATTTGAATGAATCTGCAAATTCCACTGCTCAGTAT
GCATCTAACGCTTGGTTTGCTGCTGCCAGCTCAGAGCCAGAGGAAGGGATATCTGTTTTT
GAACTGGATTATGACTATGTGCAAATTCCTTATGAGGTCACTCTCTGGATACTTCTAGCA
TCCCTTGCAAAAATAGGCTTCCACCTCTACCACAGGCTGCCAGGCCTCATGCCAGAAAGC
TGCCTCCTCATCCTGGTGGGGGCGCTGGTGGGCGGCATCATCTTCGGCACCGACCACAAA
TCGCCTCCGGTCATGGACTCCAGCATCTACTTCCTGTATCTCCTGCCACCCATCGTTCTG
GAGGGCGGCTACTTCATGCCCACCCGGCCCTTCTTTGAGAACATCGGCTCCATCCTGTGG
TGGGCAGTATTGGGGGCCCTGATCAACGCCTTGGGCATTGGCCTCTCCCTCTACCTCATC
TGCCAGGTGAAGGCCTTTGGCCTGGGCGACGTCAACCTGCTGCAGAACCTGCTGTTCGGC
AGCCTGATCTCCGCCGTGGACCCAGTGGCCGTGCTAGCCGTGTTTGAGGAAGCGCGCGTG
AACGAGCAGCTCTACATGATGATCTTTGGGGAGGCCCTGCTCAATGATGGCATTACTGTG
GTCTTATACAATATGTTAATTGCCTTTACAAAGATGCATAAATTTGAAGACATAGAAACT
GTCGACATTTTGGCTGGATGTGCCCGATTCATCGTTGTGGGGCTTGGAGGGGTATTGTTT
GGCATCGTTTTTGGATTTATTTCTGCATTTATCACACGTTTCACTCAGAATATCTCTGCA
ATTGAGCCACTCATCGTCTTCATGTTCAGCTATTTGTCTTACTTAGCTGCTGAAACCCTC
TATCTCTCCGGCATCCTGGCAATCACAGCCTGCGCAGTAACAATGAAAAAGTACGTGGAA
GAAAACGTGTCCCAGACATCATACACGACCATCAAGTACTTCATGAAGATGCTGAGCAGC
GTCAGCGAGACCTTGATCTTCATCTTCATGGGTGTGTCCACTGTGGGCAAGAATCACGAG
TGGAACTGGGCCTTCATCTGCTTCACCCTGGCCTTCTGCCAAATCTGGAGAGCCATCAGC
GTATTTGCTCTCTTCTATATCAGTAACCAGTTTCGGACTTTCCCCTTCTCCATCAAGGAC
CAGTGCATCATTTTCTACAGTGGTGTTCGAGGAGCTGGAAGTTTTTCACTTGCATTTTTG
CTTCCTCTGTCTCTTTTTCCTAGGAAGAAAATGTTTGTCACTGCTACTCTAGTAGTTATA
TACTTTACTGTATTTATTCAGGGAATCACAGTTGGCCCTCTGGTCAGGTACCTGGATGTT
AAAAAAACCAATAAAAAAGAATCCATCAATGAAGAGCTTCATATTCGTCTGATGGATCAC
TTAAAGGCTGGAATCGAAGATGTGTGTGGGCACTGGAGTCACTACCAAGTGAGAGACAAG
TTTAAGAAGTTTGATCATAGATACTTACGGAAAATCCTCATCAGAAAGAACCTACCCAAA
TCAAGCATTGTTTCTTTGTACAAGAAGCTGGAAATGAAGCAAGCCATCGAGATGGTGGAG
ACTGGGATACTGAGCTCTACAGCTTTCTCCATACCCCATCAGGCCCAGAGGATACAAGGA
ATCAAAAGACTTTCCCCTGAAGATGTGGAGTCCATAAGGGACATTCTGACATCCAACATG
TACCAAGTTCGGCAAAGGACCCTGTCCTACAACAAATACAACCTCAAACCCCAAACAAGT
GAGAAGCAGGCTAAAGAGATTCTGATCCGCCGCCAGAACACCTTAAGGGAGAGCATGAGG
AAAGGTCACAGCCTGCCCTGGGGAAAGCCGGCTGGCACCAAGAATATCCGCTACCTCTCC
TACCCCTACGGGAATCCTCAGTCTGCAGGAAGAGACACAAGGGCTGCTGGGTTCTCAGAT
GATGACAGCAGTGATCCAGGATCCCCATCCATCACGTTCAGCGCATGCTCTCGGATAGGG
TCACTTCAGAAGCAAGAGGCACAAGAAATAATACCAATGAAGAGCCTACACAGAGGAAGG
AAGGCATTCAGCTTTGGTTATCAAAGAAACACAAGCCAAGAAGAGTACTTGGGTGGAGTA
AGGAGGGTGGCCTTAAGACCCAAACCTCTGTTTCATGCAGTGGATGAGGAGGGTGAGTCT
GGAGGGGAGAGTGAGGGCAAGGCCTCTTTGGTTGAGGTTCGGTCGAGGTGGACAGCTGAC
CATGGACACGGCAGGGACCATCACAGGTCCCATAGTCCTTTGCTCCAAAAAAAATAG

Protein Properties

Number of Residues

798

Molecular Weight

89813.4

Theoretical pI

8.72

Pfam Domain Function

Na_H_Exchanger (PF00999 )

Signals

None

Transmembrane Regions

95-115
128-148
155-175
197-217
227-247
271-291
305-325
357-373
385-405
451-471

Protein Sequence

>Sodium/hydrogen exchanger 4
MALQMFVTYSPWNCLLLLVALECSEASSDLNESANSTAQYASNAWFAAASSEPEEGISVF
ELDYDYVQIPYEVTLWILLASLAKIGFHLYHRLPGLMPESCLLILVGALVGGIIFGTDHK
SPPVMDSSIYFLYLLPPIVLEGGYFMPTRPFFENIGSILWWAVLGALINALGIGLSLYLI
CQVKAFGLGDVNLLQNLLFGSLISAVDPVAVLAVFEEARVNEQLYMMIFGEALLNDGITV
VLYNMLIAFTKMHKFEDIETVDILAGCARFIVVGLGGVLFGIVFGFISAFITRFTQNISA
IEPLIVFMFSYLSYLAAETLYLSGILAITACAVTMKKYVEENVSQTSYTTIKYFMKMLSS
VSETLIFIFMGVSTVGKNHEWNWAFICFTLAFCQIWRAISVFALFYISNQFRTFPFSIKD
QCIIFYSGVRGAGSFSLAFLLPLSLFPRKKMFVTATLVVIYFTVFIQGITVGPLVRYLDV
KKTNKKESINEELHIRLMDHLKAGIEDVCGHWSHYQVRDKFKKFDHRYLRKILIRKNLPK
SSIVSLYKKLEMKQAIEMVETGILSSTAFSIPHQAQRIQGIKRLSPEDVESIRDILTSNM
YQVRQRTLSYNKYNLKPQTSEKQAKEILIRRQNTLRESMRKGHSLPWGKPAGTKNIRYLS
YPYGNPQSAGRDTRAAGFSDDDSSDPGSPSITFSACSRIGSLQKQEAQEIIPMKSLHRGR
KAFSFGYQRNTSQEEYLGGVRRVALRPKPLFHAVDEEGESGGESEGKASLVEVRSRWTAD
HGHGRDHHRSHSPLLQKK

External Links

GenBank ID Protein

148727259

UniProtKB/Swiss-Prot ID

Q6AI14

UniProtKB/Swiss-Prot Entry Name

SL9A4_HUMAN

PDB IDs

Not Available

GenBank Gene ID

GeneCard ID

GenAtlas ID

HGNC ID

References

General References

Hillier LW, Graves TA, Fulton RS, Fulton LA, Pepin KH, Minx P, Wagner-McPherson C, Layman D, Wylie K, Sekhon M, Becker MC, Fewell GA, Delehaunty KD, Miner TL, Nash WE, Kremitzki C, Oddy L, Du H, Sun H, Bradshaw-Cordum H, Ali J, Carter J, Cordes M, Harris A, Isak A, van Brunt A, Nguyen C, Du F, Courtney L, Kalicki J, Ozersky P, Abbott S, Armstrong J, Belter EA, Caruso L, Cedroni M, Cotton M, Davidson T, Desai A, Elliott G, Erb T, Fronick C, Gaige T, Haakenson W, Haglund K, Holmes A, Harkins R, Kim K, Kruchowski SS, Strong CM, Grewal N, Goyea E, Hou S, Levy A, Martinka S, Mead K, McLellan MD, Meyer R, Randall-Maher J, Tomlinson C, Dauphin-Kohlberg S, Kozlowicz-Reilly A, Shah N, Swearengen-Shahid S, Snider J, Strong JT, Thompson J, Yoakum M, Leonard S, Pearman C, Trani L, Radionenko M, Waligorski JE, Wang C, Rock SM, Tin-Wollam AM, Maupin R, Latreille P, Wendl MC, Yang SP, Pohl C, Wallis JW, Spieth J, Bieri TA, Berkowicz N, Nelson JO, Osborne J, Ding L, Meyer R, Sabo A, Shotland Y, Sinha P, Wohldmann PE, Cook LL, Hickenbotham MT, Eldred J, Williams D, Jones TA, She X, Ciccarelli FD, Izaurralde E, Taylor J, Schmutz J, Myers RM, Cox DR, Huang X, McPherson JD, Mardis ER, Clifton SW, Warren WC, Chinwalla AT, Eddy SR, Marra MA, Ovcharenko I, Furey TS, Miller W, Eichler EE, Bork P, Suyama M, Torrents D, Waterston RH, Wilson RK: Generation and annotation of the DNA sequences of human chromosomes 2 and 4. Nature. 2005 Apr 7;434(7034):724-31. [PubMed:15815621 ]
Bechtel S, Rosenfelder H, Duda A, Schmidt CP, Ernst U, Wellenreuther R, Mehrle A, Schuster C, Bahr A, Blocker H, Heubner D, Hoerlein A, Michel G, Wedler H, Kohrer K, Ottenwalder B, Poustka A, Wiemann S, Schupp I: The full-ORF clone resource of the German cDNA Consortium. BMC Genomics. 2007 Oct 31;8:399. [PubMed:17974005 ]
Denis NJ, Vasilescu J, Lambert JP, Smith JC, Figeys D: Tryptic digestion of ubiquitin standards reveals an improved strategy for identifying ubiquitinated proteins by mass spectrometry. Proteomics. 2007 Mar;7(6):868-74. [PubMed:17370265 ]