Showing Protein Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 (HMDBP06975)

• 12594

1. B3Gal-T8
2. Beta-1,3-galactosyltransferase
3. C1GalT1
4. Core 1 O-glycan T-synthase
5. Core 1 UDP-galactose:N-acetylgalactosamine-alpha-R beta 1,3-galactosyltransferase 1
6. Core 1 beta1,3-galactosyltransferase 1
7. Core 1 beta3-Gal-T1

• Mucin type O-glycan biosynthesis
• protein glycosylation

1. Membrane
2. Single-pass type II membrane protein

>1092 bp
ATGGCCTCTAAATCCTGGCTGAATTTTTTAACCTTCCTCTGTGGATCAGCAATAGGATTT
CTTTTATGTTCTCAGCTATTTAGTATTTTGTTGGGAGAAAAGGTTGACACCCAGCCTAAT
GTTCTTCATAATGATCCTCATGCAAGGCATTCAGATGATAATGGACAGAATCATCTAGAA
GGACAAATGAACTTCAATGCAGATTCTAGCCAACATAAAGATGAGAACACAGACATTGCT
GAAAACCTCTATCAGAAAGTTAGAATTCTTTGCTGGGTTATGACCGGCCCTCAAAACCTA
GAGAAAAAGGCCAAACACGTCAAAGCTACTTGGGCCCAGCGTTGTAACAAAGTGTTGTTT
ATGAGTTCAGAAGAAAATAAAGACTTCCCTGCTGTGGGACTGAAAACCAAAGAAGGCAGA
GATCAACTATACTGGAAAACAATTAAAGCTTTTCAGTATGTTCATGAACATTATTTAGAA
GATGCTGATTGGTTTTTGAAAGCAGATGATGACACGTATGTCATACTAGACAATTTGAGG
TGGCTTCTTTCAAAATACGACCCTGAAGAACCCATTTACTTTGGGAGAAGATTTAAGCCT
TATGTAAAGCAGGGCTACATGAGTGGAGGAGCAGGATATGTACTAAGCAAAGAAGCCTTG
AAAAGATTTGTTGATGCATTTAAAACAGACAAGTGTACACATAGTTCCTCCATTGAAGAC
TTAGCACTGGGGAGATGCATGGAAATTATGAATGTAGAAGCAGGAGATTCCAGAGATACC
ATTGGAAAAGAAACTTTTCATCCCTTTGTGCCAGAACACCATTTAATTAAAGGTTATCTA
CCTAGAACGTTTTGGTACTGGAATTACAACTATTATCCTCCTGTAGAGGGTCCTGGTTGC
TGCTCTGATCTTGCAGTTTCTTTTCACTATGTTGATTCTACAACCATGTATGAGTTAGAA
TACCTCGTTTATCATCTTCGTCCATATGGTTATTTATACAGATATCAACCTACCTTACCT
GAACGTATACTAAAGGAAATTAGTCAAGCAAACAAAAATGAAGATACAAAAGTGAAGTTA
GGAAATCCTTGA

• Fringe (PF02434 )

>Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1
MASKSWLNFLTFLCGSAIGFLLCSQLFSILLGEKVDTQPNVLHNDPHARHSDDNGQNHLE
GQMNFNADSSQHKDENTDIAENLYQKVRILCWVMTGPQNLEKKAKHVKATWAQRCNKVLF
MSSEENKDFPAVGLKTKEGRDQLYWKTIKAFQYVHEHYLEDADWFLKADDDTYVILDNLR
WLLSKYDPEEPIYFGRRFKPYVKQGYMSGGAGYVLSKEALKRFVDAFKTDKCTHSSSIED
LALGRCMEIMNVEAGDSRDTIGKETFHPFVPEHHLIKGYLPRTFWYWNYNYYPPVEGPGC
CSDLAVSFHYVDSTTMYELEYLVYHLRPYGYLYRYQPTLPERILKEISQANKNEDTKVKL
GNP

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4. Ju T, Brewer K, D'Souza A, Cummings RD, Canfield WM: Cloning and expression of human core 1 beta1,3-galactosyltransferase. J Biol Chem. 2002 Jan 4;277(1):178-86. Epub 2001 Oct 24. [PubMed:11677243 ]
5. Ju T, Cummings RD: A unique molecular chaperone Cosmc required for activity of the mammalian core 1 beta 3-galactosyltransferase. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16613-8. Epub 2002 Dec 3. [PubMed:12464682 ]
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7. Zhu L, Tang W, Li G, Lv J, Ding J, Yu L, Zhao M, Li Y, Zhang X, Shen Y, Zhang H, Wang H: Interaction between variants of two glycosyltransferase genes in IgA nephropathy. Kidney Int. 2009 Jul;76(2):190-8. doi: 10.1038/ki.2009.99. Epub 2009 Apr 8. [PubMed:19357720 ]