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Showing Protein Lipase member I (HMDBP07318)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 7127 metabolites
Identification
HMDB Protein ID HMDBP07318
Secondary Accession Numbers
  • 12940
Name Lipase member I
Synonyms
  1. CT17
  2. Cancer/testis antigen 17
  3. LPD lipase
  4. Membrane-associated phosphatidic acid-selective phospholipase A1-beta
  5. mPA-PLA1 beta
Gene Name LIPI
Protein Type Unknown
Biological Properties
General Function Involved in catalytic activity
Specific Function Hydrolyzes specifically phosphatidic acid (PA) to produce lysophosphatidic acid (LPA)
Pathways Not Available
Reactions Not Available
GO Classification
Function
catalytic activity
Process
metabolic process
primary metabolic process
lipid metabolic process
Cellular Location
  1. Secreted (Potential)
Gene Properties
Chromosome Location Chromosome:2
Locus 21q11.2
SNPs LIPI
Gene Sequence 
>1446 bp
ATGTTGCTCAAATGTTTACATAATAACTTGTGCCAAAAATATAGTGCTCATGCTTTTCAG
TTCTCACCCAGAAATGTCCTGTGGCTTCTAGTTGTGTGCCTGAGATCAGATAATAAAAGA
CCATGCCTTGAATTCTCTCAGCTAAGTGTAAAGGATTCCTTCAGAGATTTATTTATTCCG
AGAATAGAGACCATTCTGATGATGTATACAAGGAACAACCTAAACTGTGCTGAGCCACTG
TTTGAACAAAATAACTCACTTAATGTTAATTTCAACACACAAAAGAAAACAGTCTGGCTT
ATTCACGGATACAGACCAGTAGGCTCCATCCCATTATGGCTTCAGAACTTCGTAAGGATT
TTGCTGAATGAAGAAGATATGAATGTAATTGTAGTAGACTGGAGCCGGGGTGCTACAACT
TTTATTTATAATAGAGCAGTTAAAAACACCAGAAAAGTTGCTGTGAGTTTGAGTGTGCAC
ATTAAAAATCTTTTGAAGCATGGTGCATCTCTTGACAATTTTCATTTCATAGGTGTGAGC
TTAGGGGCTCATATCAGTGGATTTGTTGGAAAGATATTTCATGGTCAACTTGGAAGAATA
ACAGGTCTTGACCCTGCTGGGCCAAGGTTCTCCAGAAAACCACCATATAGCAGATTAGAT
TACACGGATGCAAAGTTTGTGGATGTCATCCATTCTGACTCCAATGGTTTAGGCATTCAA
GAGCCCTTGGGACATATAGATTTTTATCCAAATGGAGGAAATAAACAACCTGGCTGTCCT
AAATCAATTTTCTCAGGAATTCAATTCATTAAATGCAACCACCAGAGAGCAGTTCACTTG
TTCATGGCATCTTTAGAAACAAACTGCAATTTTATTTCATTTCCTTGTCGTTCATACAAA
GATTACAAGACTAGCTTATGTGTGGACTGTGACTGTTTTAAGGAAAAATCATGTCCTCGG
CTGGGTTATCAAGCCAAGCTATTTAAAGGTGTTTTAAAAGAAAGGATGGAAGGAAGACCT
CTTAGGACCACTGTGTTTTTGGATACAAGTGGTACATATCCATTCTGTACCTATTATTTT
GTTCTCAGTATAATTGTTCCAGATAAAACTATGATGGATGGCTCGTTTTCATTTAAATTA
TTAAATCAGCTTGGAATGATTGAAGAGCCAAGGCTTTATGAAAAGAACAAACCATTTTAT
AAACTTCAAGAAGTCAAGATTCTTGCTCAATTTTATAATGACTTTGTAAATATTTCAAGC
ATTGGTTTGACATATTTCCAGAGCTCAAATCTGCAGTGTTCCACATGCACATACAAGATC
CAGAGACTCATGTTAAAATCACTTACATACCCAGAAAGACCACCACTTTGCAGGTATAAT
ATTGTACTTAAAGACAGAGAGGAAGTGTTTCTTAATCCAAACACATGTACACCAAAGAAC
ACATAA
Protein Properties
Number of Residues 460
Molecular Weight 52991.0
Theoretical pI 9.28
Pfam Domain Function
Signals
  • 1-15
Transmembrane Regions
  • None
Protein Sequence 
>Lipase member I
MRVYIFLCLMCWVRSDNKRPCLEFSQLSVKDSFRDLFIPRIETILMMYTRNNLNCAEPLF
EQNNSLNVNFNTQKKTVWLIHGYRPVGSIPLWLQNFVRILLNEEDMNVIVVDWSRGATTF
IYNRAVKNTRKVAVSLSVHIKNLLKHGASLDNFHFIGVSLGAHISGFVGKIFHGQLGRIT
GLDPAGPRFSRKPPYSRLDYTDAKFVDVIHSDSNGLGIQEPLGHIDFYPNGGNKQPGCPK
SIFSGIQFIKCNHQRAVHLFMASLETNCNFISFPCRSYKDYKTSLCVDCDCFKEKSCPRL
GYQAKLFKGVLKERMEGRPLRTTVFLDTSGTYPFCTYYFVLSIIVPDKTMMDGSFSFKLL
NQLGMIEEPRLYEKNKPFYKLQEVKILAQFYNDFVNISSIGLTYFQSSNLQCSTCTYKIQ
RLMLKSLTYPERPPLCRYNIVLKDREEVFLNPNTCTPKNT
GenBank ID Protein 39752679
UniProtKB/Swiss-Prot ID Q6XZB0
UniProtKB/Swiss-Prot Entry Name LIPI_HUMAN
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID LIPI
GenAtlas ID LIPI
HGNC ID HGNC:18821
References
General References
  1. Matsuoka S, Ballif BA, Smogorzewska A, McDonald ER 3rd, Hurov KE, Luo J, Bakalarski CE, Zhao Z, Solimini N, Lerenthal Y, Shiloh Y, Gygi SP, Elledge SJ: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. Science. 2007 May 25;316(5828):1160-6. [PubMed:17525332 ]
  2. Hattori M, Fujiyama A, Taylor TD, Watanabe H, Yada T, Park HS, Toyoda A, Ishii K, Totoki Y, Choi DK, Groner Y, Soeda E, Ohki M, Takagi T, Sakaki Y, Taudien S, Blechschmidt K, Polley A, Menzel U, Delabar J, Kumpf K, Lehmann R, Patterson D, Reichwald K, Rump A, Schillhabel M, Schudy A, Zimmermann W, Rosenthal A, Kudoh J, Schibuya K, Kawasaki K, Asakawa S, Shintani A, Sasaki T, Nagamine K, Mitsuyama S, Antonarakis SE, Minoshima S, Shimizu N, Nordsiek G, Hornischer K, Brant P, Scharfe M, Schon O, Desario A, Reichelt J, Kauer G, Blocker H, Ramser J, Beck A, Klages S, Hennig S, Riesselmann L, Dagand E, Haaf T, Wehrmeyer S, Borzym K, Gardiner K, Nizetic D, Francis F, Lehrach H, Reinhardt R, Yaspo ML: The DNA sequence of human chromosome 21. Nature. 2000 May 18;405(6784):311-9. [PubMed:10830953 ]
  3. Wen XY, Hegele RA, Wang J, Wang DY, Cheung J, Wilson M, Yahyapour M, Bai Y, Zhuang L, Skaug J, Young TK, Connelly PW, Koop BF, Tsui LC, Stewart AK: Identification of a novel lipase gene mutated in lpd mice with hypertriglyceridemia and associated with dyslipidemia in humans. Hum Mol Genet. 2003 May 15;12(10):1131-43. [PubMed:12719377 ]
  4. Hiramatsu T, Sonoda H, Takanezawa Y, Morikawa R, Ishida M, Kasahara K, Sanai Y, Taguchi R, Aoki J, Arai H: Biochemical and molecular characterization of two phosphatidic acid-selective phospholipase A1s, mPA-PLA1alpha and mPA-PLA1beta. J Biol Chem. 2003 Dec 5;278(49):49438-47. Epub 2003 Sep 8. [PubMed:12963729 ]