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Identification
HMDB Protein ID HMDBP07324
Secondary Accession Numbers
  • 12946
Name Phosphatidate phosphatase PPAPDC1B
Synonyms
  1. Phosphatidic acid phosphatase type 2 domain-containing protein 1B
Gene Name PPAPDC1B
Protein Type Enzyme
Biological Properties
General Function Involved in catalytic activity
Specific Function Displays magnesium-independent phosphatidate phosphatase activity in vitro. Catalyzes the conversion of phosphatidic acid to diacylglycerol. May be a metastatic suppressor for hepatocellular carcinoma.
Pathways Not Available
Reactions
A 1,2-diacylglycerol 3-phosphate + Water → a 1,2-diacyl-sn-glycerol + Phosphate details
GO Classification
Biological Process
phospholipid dephosphorylation
Cellular Component
cytoplasm
plasma membrane
integral to membrane
Component
membrane
cell part
Function
catalytic activity
Molecular Function
phosphatidate phosphatase activity
Cellular Location
  1. Membrane
  2. Multi-pass membrane protein (Potential)
Gene Properties
Chromosome Location 8
Locus 8p11.23
SNPs PPAPDC1B
Gene Sequence
>672 bp
ATGTGGCTCTACCGGAACCCCTACGTGGAGGCGGAGTATTTCCCCACCAAGCCGATGTTT
GTTATTGCATTTCTCTCTCCACTGTCTCTGATCTTCCTGGCCAAATTTCTCAAGAAGGCA
GACACAAGAGACAGCAGACAAGCCTGCCTGGCTGCCAGCCTTGCCCTGGCTCTGAATGGC
GTCTTTACCAACACAATAAAACTGATCGTAGGGAGGCCACGCCCAGATTTCTTCTACCGC
TGCTTCCCTGATGGGCTAGCCCATTCTGACTTGATGTGTACAGGGGATAAGGACGTGGTG
AATGAGGGCCGAAAGAGCTTCCCCAGTGGACATTCTTCCTTTGCATTTGCTGGTCTGGCC
TTTGCGTCCTTCTACCTGGCAGGGAAGTTACACTGCTTCACACCACAAGGCCGTGGGAAA
TCTTGGAGGTTCTGTGCCTTTCTGTCACCTCTACTTTTTGCAGCTGTGATTGCACTGTCC
CGCACATGTGACTACAAGCATCACTGGCAAGATGTACTAGTTGGATCCATGATTGGAATG
ACATTTGCCTATGTCTGCTATCGGCAGTATTATCCTCCTCTGACTGATGCAGAATGCCAT
AAACCATTTCAAGACAAACTTGTACTTTCCACTGCACAGAAGCCTGGGGATTCTTATTGT
TTTGATATTTAA
Protein Properties
Number of Residues 223
Molecular Weight 29484.025
Theoretical pI 8.504
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>Phosphatidate phosphatase PPAPDC1B
MWLYRNPYVEAEYFPTKPMFVIAFLSPLSLIFLAKFLKKADTRDSRQACLAASLALALNG
VFTNTIKLIVGRPRPDFFYRCFPDGLAHSDLMCTGDKDVVNEGRKSFPSGHSSFAFAGLA
FASFYLAGKLHCFTPQGRGKSWRFCAFLSPLLFAAVIALSRTCDYKHHWQDVLVGSMIGM
TFAYVCYRQYYPPLTDAECHKPFQDKLVLSTAQKPGDSYCFDI
GenBank ID Protein 21542541
UniProtKB/Swiss-Prot ID Q8NEB5
UniProtKB/Swiss-Prot Entry Name PPC1B_HUMAN
PDB IDs Not Available
GenBank Gene ID BC033025
GeneCard ID PPAPDC1B
GenAtlas ID PPAPDC1B
HGNC ID HGNC:25026
References
General References
  1. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  2. Takeuchi M, Harigai M, Momohara S, Ball E, Abe J, Furuichi K, Kamatani N: Cloning and characterization of DPPL1 and DPPL2, representatives of a novel type of mammalian phosphatidate phosphatase. Gene. 2007 Sep 15;399(2):174-80. Epub 2007 Jun 2. [PubMed:17590538 ]
  3. Wu X, Jia HL, Wang YF, Ren N, Ye QH, Sun HC, Wang L, Liu YK, Tang ZY, Qin LX: HTPAP gene on chromosome 8p is a candidate metastasis suppressor for human hepatocellular carcinoma. Oncogene. 2006 Mar 16;25(12):1832-40. [PubMed:16261160 ]