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Identification
HMDB Protein ID HMDBP07344
Secondary Accession Numbers
  • 12966
Name Transmembrane protein 55A
Synonyms
  1. PtdIns-4,5-P2 4-Ptase II
  2. Type II phosphatidylinositol 4,5-bisphosphate 4-phosphatase
Gene Name TMEM55A
Protein Type Unknown
Biological Properties
General Function Involved in hydrolase activity
Specific Function Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 4,5-bisphosphate. Does not hydrolyze phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-bisphosphate, inositol 3,5-bisphosphate, inositol 3,4-bisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3-monophosphate.
Pathways Not Available
Reactions
1-phosphatidyl-myo-inositol 4,5-bisphosphate + Water → 1-phosphatidyl-1D-myo-inositol 5-phosphate + Phosphate details
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + Water → 1-phosphatidyl-1D-myo-inositol 5-phosphate + Phosphate details
GO Classification
Cellular Component
late endosome membrane
lysosomal membrane
integral to membrane
Molecular Function
hydrolase activity
Cellular Location
  1. Late endosome membrane
  2. Lysosome membrane
  3. Multi-pass membrane protein
  4. Multi-pass membrane protein
Gene Properties
Chromosome Location 8
Locus 8q21.3
SNPs TMEM55A
Gene Sequence
>774 bp
ATGGCTGCTGATGGGGTGGACGAACGCTCGCCTCTGCTGTCAGCATCCCACTCCGGAAAT
GTCACTCCCACCGCCCCACCGTACTTGCAAGAAAGCAGCCCCAGAGCGGAGCTCCCACCT
CCATATACAGCCATTGCCAGTCCAGACGCCAGTGGTATTCCAGTAATAAACTGCCGTGTG
TGCCAATCACTAATCAATTTGGATGGCAAGCTTCACCAGCATGTGGTTAAGTGCACAGTT
TGCAATGAAGCTACGCCAATCAAAAACCCCCCAACAGGCAAGAAATATGTTAGATGCCCT
TGTAATTGTCTTCTCATTTGTAAGGACACATCTCGGCGAATAGGATGCCCAAGACCCAAC
TGTAGACGGATAATTAACCTTGGCCCAGTAATGCTTATTTCTGAAGAACAACCAGCTCAG
CCTGCATTGCCAATCCAACCAGAAGGTACAAGGGTCGTGTGTGGGCACTGTGGAAACACA
TTCCTGTGGATGGAACTGAGGTTCAACACTCTGGCAAAATGCCCACACTGCAAAAAAATC
TCCTCAGTGGGTAGTGCACTTCCACGAAGACGCTGCTGTGCATATATTACCATTGGAATG
ATATGTATTTTCATTGGAGTTGGGTTAACTGTTGGCACCCCAGATTTTGCAAGGCGATTT
CGAGCAACCTATGTTTCTTGGGCAATTGCTTATCTCCTAGGATTGATCTGCCTTATCCGA
GCTTGTTATTGGGGAGCCATAAGAGTCAGTTATCCAGAACACAGTTTTGCATAA
Protein Properties
Number of Residues 257
Molecular Weight 28080.62
Theoretical pI 8.679
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>Transmembrane protein 55A
MAADGVDERSPLLSASHSGNVTPTAPPYLQESSPRAELPPPYTAIASPDASGIPVINCRV
CQSLINLDGKLHQHVVKCTVCNEATPIKNPPTGKKYVRCPCNCLLICKDTSRRIGCPRPN
CRRIINLGPVMLISEEQPAQPALPIQPEGTRVVCGHCGNTFLWMELRFNTLAKCPHCKKI
SSVGSALPRRRCCAYITIGMICIFIGVGLTVGTPDFARRFRATYVSWAIAYLLGLICLIR
ACYWGAIRVSYPEHSFA
GenBank ID Protein 189054014
UniProtKB/Swiss-Prot ID Q8N4L2
UniProtKB/Swiss-Prot Entry Name TM55A_HUMAN
PDB IDs Not Available
GenBank Gene ID AK313783
GeneCard ID TMEM55A
GenAtlas ID TMEM55A
HGNC ID HGNC:25452
References
General References
  1. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [PubMed:14702039 ]
  2. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  3. Bechtel S, Rosenfelder H, Duda A, Schmidt CP, Ernst U, Wellenreuther R, Mehrle A, Schuster C, Bahr A, Blocker H, Heubner D, Hoerlein A, Michel G, Wedler H, Kohrer K, Ottenwalder B, Poustka A, Wiemann S, Schupp I: The full-ORF clone resource of the German cDNA Consortium. BMC Genomics. 2007 Oct 31;8:399. [PubMed:17974005 ]
  4. Ungewickell A, Hugge C, Kisseleva M, Chang SC, Zou J, Feng Y, Galyov EE, Wilson M, Majerus PW: The identification and characterization of two phosphatidylinositol-4,5-bisphosphate 4-phosphatases. Proc Natl Acad Sci U S A. 2005 Dec 27;102(52):18854-9. Epub 2005 Dec 19. [PubMed:16365287 ]