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Identification
HMDB Protein ID HMDBP07346
Secondary Accession Numbers
  • 12968
Name Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2
Synonyms
  1. Lipid phosphatase TPIP
  2. TPTE and PTEN homologous inositol lipid phosphatase
Gene Name TPTE2
Protein Type Enzyme
Biological Properties
General Function Involved in protein tyrosine/serine/threonine phosphatase activity
Specific Function Not Available
Pathways Not Available
Reactions
Phosphatidylinositol 3,4,5-trisphosphate + Water → phosphatidylinositol 4,5-bisphosphate + Phosphate details
GO Classification
Biological Process
small molecule metabolic process
phosphatidylinositol biosynthetic process
peptidyl-tyrosine dephosphorylation
Cellular Component
endoplasmic reticulum membrane
integral to membrane
Golgi membrane
Component
membrane
cell part
Function
phosphoprotein phosphatase activity
protein tyrosine phosphatase activity
hydrolase activity, acting on ester bonds
catalytic activity
hydrolase activity
phosphoric ester hydrolase activity
phosphatase activity
transmembrane transporter activity
substrate-specific transmembrane transporter activity
ion transmembrane transporter activity
protein tyrosine/serine/threonine phosphatase activity
transporter activity
ion channel activity
Molecular Function
protein tyrosine/serine/threonine phosphatase activity
ion channel activity
phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity
protein tyrosine phosphatase activity
Process
phosphorus metabolic process
phosphate metabolic process
dephosphorylation
protein amino acid dephosphorylation
metabolic process
establishment of localization
transport
cellular metabolic process
transmembrane transport
ion transport
Cellular Location
  1. Isoform 4:Cytoplasm
Gene Properties
Chromosome Location 13
Locus 13q12.11
SNPs TPTE2
Gene Sequence
>1569 bp
ATGAATGAAAGTCCACAGACAAACGAATTTAAAGGAACAACCGAGGAGGCACCTGCGAAA
GAAAGCCCACACACAAGTGAATTTAAAGGAGCAGCCCTGGTGTCACCTATCAGTAAAAGT
ATGTTAGAACGACTTTCCAAGTTTGAAGTTGAAGATGCTGAAAATGTTGCTTCATATGAC
AGCAAGATTAAGAAAATTGTGCATTCAATTGTATCATCCTTTGCATTTGGAATATTTGGA
GTTTTCCTGGTCTTACTGGATGTCACTCTCCTCCTTGCCGACCTAATTTTCACTGACAGC
AAACTTTATATTCCTTTGGAGTATCGTTCTATTTCTCTAGCTATTGGCTTATTTTTTCTC
ATGGATGTTCTTCTTCGAGTATTTGTAGAAGGGAGACAGCAGTATTTTTCTGACTTATTT
AACATTTTAGATACTGCCATTATTGTGATTCCTCTGCTGGTTGATGTCATTTACATTTTT
TTTGACATTAAGTTGCTTAGGAATATTCCCAGATGGACACATTTAGTTCGACTTCTACGA
CTTATTATTCTGATAAGAATTTTTCATCTGCTTCATCAAAAAAGACAACTTGAAAAGCTG
ATGAGAAGGCTGGTTTCAGAAAACAAAAGGCGATACACAAGGGATGGATTTGACCTAGAC
CTCACTTACGTTACAGAACGTATTATTGCTATGTCATTTCCATCTTCTGGAAGGCAGTCT
TTCTATAGAAATCCAATTGAGGAAGTTGTGCGGTTTCTAGATAAGAAACATCGAAACCAC
TATCGAGTCTACAATCTATGCAGTGAAAGAGCTTATGATCCTAAGCACTTCCATAATAGG
GTCAGTAGAATCATGATTGATGATCATAATGTCCCCACTCTACATGAGATGGTGGTTTTC
ACCAAGGAAGTAAATGAGTGGATGGCTCAAGATCTTGAAAACATCGTAGCGATTCACTGT
AAAGGAGGCAAAGGAAGAACCGGGACTATGGTTTGTGCCCTCCTTATTGCCTCCGAAATA
TTTTTAACTGCCGAGGAAAGCCTATATTATTTTGGAGAAAGGCGAACCAATAAAACCCAC
AGCAATAAATTTCAGGGAGTAGAAACTCCTTCTCAGAATAGATATGTTGGATATTTTGCA
CAAGTGAAACATCTCTACAACTGGAATCTCCCTCCAAGACGGATACTCTTTATAAAAAGA
TTCATTATTTATTCGATTCGTGGTGATGTATGTGATCTAAAAGTCCAAGTAGTAATGGAG
AAAAAGGTTGTCTTTTCCAGTACTTCATTAGGAAATTGTTCGATATTGCATGACATTGAA
ACAGACAAAATATTAATTAATGTATATGACGGTCCACCTCTGTATGATGATGTGAAAGTG
CAGTTTTTCTCTTCGAATCTTCCTAAATACTATGACAATTGTCCATTTTTCTTCTGGTTC
AACACGTCTTTTATTCAAAATAACAGGCTTTGTCTACCAAGAAATGAATTGGATAATCCA
CATAAACAAAAAGCATGGAAAATTTATCCACCAGAATTTGCTGTGGAGATACTTTTTGGC
GAGAAATGA
Protein Properties
Number of Residues 522
Molecular Weight 48385.14
Theoretical pI 8.674
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase TPTE2
MNESPQTNEFKGTTEEAPAKESPHTSEFKGAALVSPISKSMLERLSKFEVEDAENVASYD
SKIKKIVHSIVSSFAFGIFGVFLVLLDVTLLLADLIFTDSKLYIPLEYRSISLAIGLFFL
MDVLLRVFVEGRQQYFSDLFNILDTAIIVIPLLVDVIYIFFDIKLLRNIPRWTHLVRLLR
LIILIRIFHLLHQKRQLEKLMRRLVSENKRRYTRDGFDLDLTYVTERIIAMSFPSSGRQS
FYRNPIEEVVRFLDKKHRNHYRVYNLCSERAYDPKHFHNRVSRIMIDDHNVPTLHEMVVF
TKEVNEWMAQDLENIVAIHCKGGKGRTGTMVCALLIASEIFLTAEESLYYFGERRTNKTH
SNKFQGVETPSQNRYVGYFAQVKHLYNWNLPPRRILFIKRFIIYSIRGDVCDLKVQVVME
KKVVFSSTSLGNCSILHDIETDKILINVYDGPPLYDDVKVQFFSSNLPKYYDNCPFFFWF
NTSFIQNNRLCLPRNELDNPHKQKAWKIYPPEFAVEILFGEK
GenBank ID Protein 213972591
UniProtKB/Swiss-Prot ID Q6XPS3
UniProtKB/Swiss-Prot Entry Name TPTE2_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_199254.2
GeneCard ID TPTE2
GenAtlas ID TPTE2
HGNC ID HGNC:17299
References
General References
  1. Dunham A, Matthews LH, Burton J, Ashurst JL, Howe KL, Ashcroft KJ, Beare DM, Burford DC, Hunt SE, Griffiths-Jones S, Jones MC, Keenan SJ, Oliver K, Scott CE, Ainscough R, Almeida JP, Ambrose KD, Andrews DT, Ashwell RI, Babbage AK, Bagguley CL, Bailey J, Bannerjee R, Barlow KF, Bates K, Beasley H, Bird CP, Bray-Allen S, Brown AJ, Brown JY, Burrill W, Carder C, Carter NP, Chapman JC, Clamp ME, Clark SY, Clarke G, Clee CM, Clegg SC, Cobley V, Collins JE, Corby N, Coville GJ, Deloukas P, Dhami P, Dunham I, Dunn M, Earthrowl ME, Ellington AG, Faulkner L, Frankish AG, Frankland J, French L, Garner P, Garnett J, Gilbert JG, Gilson CJ, Ghori J, Grafham DV, Gribble SM, Griffiths C, Hall RE, Hammond S, Harley JL, Hart EA, Heath PD, Howden PJ, Huckle EJ, Hunt PJ, Hunt AR, Johnson C, Johnson D, Kay M, Kimberley AM, King A, Laird GK, Langford CJ, Lawlor S, Leongamornlert DA, Lloyd DM, Lloyd C, Loveland JE, Lovell J, Martin S, Mashreghi-Mohammadi M, McLaren SJ, McMurray A, Milne S, Moore MJ, Nickerson T, Palmer SA, Pearce AV, Peck AI, Pelan S, Phillimore B, Porter KM, Rice CM, Searle S, Sehra HK, Shownkeen R, Skuce CD, Smith M, Steward CA, Sycamore N, Tester J, Thomas DW, Tracey A, Tromans A, Tubby B, Wall M, Wallis JM, West AP, Whitehead SL, Willey DL, Wilming L, Wray PW, Wright MW, Young L, Coulson A, Durbin R, Hubbard T, Sulston JE, Beck S, Bentley DR, Rogers J, Ross MT: The DNA sequence and analysis of human chromosome 13. Nature. 2004 Apr 1;428(6982):522-8. [PubMed:15057823 ]
  2. Walker SM, Downes CP, Leslie NR: TPIP: a novel phosphoinositide 3-phosphatase. Biochem J. 2001 Dec 1;360(Pt 2):277-83. [PubMed:11716755 ]
  3. Tapparel C, Reymond A, Girardet C, Guillou L, Lyle R, Lamon C, Hutter P, Antonarakis SE: The TPTE gene family: cellular expression, subcellular localization and alternative splicing. Gene. 2003 Dec 24;323:189-99. [PubMed:14659893 ]